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HCID 8095Erstellt: 26. Oktober 2026

2-Ethoxy-ethylacetat

ETHYL GLYCOL ACETATE · EEA · 2-ETHOXYETHYL ACETATE · CELLOSOLVE ACETATE · CSAC · egeea · Ethoxyethyl acetate · ETHYL CELLOSOLVE ACETATE

https://huagongshe.com/de/chemical/8095

Molekülstruktur von 2-Ethoxy-ethylacetat

Identifikatoren & physikalische Daten

CAS No.111-15-9
SummenformelC6H12O3
Durchschnittliche Molmasse132,16 g/mol
Monoisotopische Masse132,07864424 g/mol
SMILESCCOCCOC(C)=O
InChIKeySVONRAPFKPVNKG-UHFFFAOYSA-N
PubChem CID8095
ChEMBLCHEMBL1427293
EC No.203-839-2
DTXSIDDTXSID9021928
Lokaler Name2-Ethoxy-ethylacetat

Chemische & physikalische Eigenschaften

XLogP0,3
Polarare Oberfläche (TPSA)35,5
H-Brücken-Donoren0
H-Brücken-Akzeptoren3
Frei drehbare Bindungen5
Schwere Atome9
Formalladung0
Komplexität80,4
StoffklassenTeratogensVolatile Organic Compound (VOC)
SolventsSolvents -> Glycol Ethers (E Series)
KosmetikaCosmetics ingredient -> Other (Specify)Cosmetic ingredients (Ethoxyethanol Acetate) -> CIR (Cosmetic Ingredient Review)
SpringerMaterials PropertiesBoiling point
LogP (Verteilungskoeffizient)log Kow = 0.24
GeruchMILD ESTER-LIKE ODOR BECOMES OBJECTIONABLE IN HIGH CONCN ...Pleasant odor
Geschmack... A BITTER ACID TASTE
Dichte0.974 at 68 °F (USCG, 1999) - Less dense than waterwill floatSpecific gravity: 0.975 at 20 °C/20 °CRelative density (water = 1): 0.97 (20 °C)0.980.9740 @ 20°C0.975 g/mL at 25 °C(lit.)
Viscosity1.32 cP at 20 °C
Color/FormColorless liquid
Löslichkeitgreater than or equal to 100 mg/mL at 66 °F (NTP, 1992)Coefficient of expansion = 0.00112 °C-1 at 20 °CDielectric constant = 7.567 at 30 °CWater azeotrope = 44.4 wt % at 97 °CHildebrand solubility parameter(delta) = 17.8 MPaVery soluble in ethyl alcohol, ethyl etherMISCIBLE WITH OLIVE OIL IN ALL PROPMiscible with aromatic hydrocarbonsIn water, 187,000 mg/L at 20 °CH2O: solubleabout 6 parts230 g/L (20 ºC)
Flammpunkt135 °F (NTP, 1992)47 °C52 °C (Closed cup)51.1 °C c.c.124 °F
Schmelzpunkt-61 °C
Siedepunkt156 °C(lit.)
Dampfdichte4.6 (vs air)
Dampfdruck2 mm Hg ( 20 °C)
Brechungsindexn20/D 1.406(lit.)
LagerbedingungenStore below +30°C.
AggregatzustandColorless liquid
FarbeColorless
pH4-5 (H2O, 20℃)(saturated solution)
Explosionsgrenze1.7-10%(V)
Geruchsschwelle0.049ppm
Spezifische WärmekapazitätCp(liquid): 2.85 J/(g·K), at 25℃
Merck14,3751
BRN1748677
Henry-Konstante9.07(x 10-7 atmm3/mol) at 25 °C (approximate - calculated from water solubility and vapor pressure) 33.0(x 10-7 atmm3/mol) at 30.00 °C (headspace-GC, Hovorka et al., 2002)
Dielektrizitätskonstante7.6(30℃)
StabilitätStable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases, nitrates.
Kosmetik-Inhaltsstoffe FunktionenSOLVENT
InChI1S/C6H12O3/c1-3-8-4-5-9-6(2)7/h3-5H2,1-2H3
InChIKeySVONRAPFKPVNKG-UHFFFAOYSA-N
SMILESCCOCCOC(C)=O
LogP (Verteilungskoeffizient)0.449 (est)
CAS Datenbank111-15-9(CAS DataBase Reference)
NIST chemische Informationen2-Ethoxyethyl acetate(111-15-9)
EPA chemische InformationenEthylene glycol monoethyl ether acetate (111-15-9)

Sicherheit & Vorschriften

GHS-EinstufungDangerH226: Flammable liquid and vapor [Warning Flammable liquids]P203, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P317, P318, P321, P330, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 8.8% (36 of 410) of reports.H226 (90.5%): Flammable liquid and vapor [Warning Flammable liquids]
Regulatorische InformationenChemical: Ethanol, 2-ethoxy-, acetateHazard Traits - Developmental ToxicityNeurotoxicityReproductive ToxicityEthanol, 2-ethoxy-, 1-acetate is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanol, 2-ethoxy-, 1-acetate are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)S - indicates a substance that is identified in a final Significant New Use Rule.Substance: 2-ethoxyethyl acetateEthanol, 2-ethoxy-, acetate: HSNO Approval: HSR001157 Approved with controls
Weitere SicherheitsinformationenIMAP assessments - Ethanol, 2-ethoxy-, acetate: Environment tier I assessment
DOT-KennzeichnungFlammable Liquid
BrandgefahrenExcerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.Flammable. Above 51.1 °C explosive vapour/air mixtures may be formed.
BrandpotenzialMODERATE, WHEN EXPOSED TO HEAT OR FLAMECAN REACT WITH OXIDIZING MATERIALS. SPONTANEOUS HEATING: NO.
GesundheitsgefahrenVapors irritate nose and eyes in high concentrations. Liquid irritates skin in prolonged or repeated contact. (USCG, 1999)· May cause toxic effects if inhaled or absorbed through skin.
GefahrenübersichtLaboratory animals die after twelve 8-hour exposures of 450 ppmpathological examination shows kidney damage[ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] See Glycol ethers.
DOT-Nummer und Handbuch1172 129
FDA-AnforderungenEthylene glycol monoethyl ether acetate is an indirect food additive for use only as a component of adhesives.
Reaktive GruppeEsters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
EG-EinstufungSymbol: TR: 60-61-20/21/22S: 53-45Note: E
UN-EinstufungUN Hazard Class: 3UN Pack Group: III
BrandbekämpfungExcerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
Erste-Hilfe-MaßnahmenFresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Refer for medical attention .
Freisetungsmaßnahmen· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
Erste HilfeEYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.General First Aid:(General first aid procedures)
Sichere LagerungFireproof. Separated from strong oxidants, strong bases and strong acids. Keep in the dark.
Expositionsschutz und Persönliche Schutzausrüstung· Wear positive pressure self-contained breathing apparatus (SCBA).Biological Exposure Indices (BEI) [ACGIH] - 2-Ethoxyacetic acid in urine = 40 mg/g creatinineend of shift at end of workweek2.0 [ppm], sum of the concentrations of CAS 110-80-5 and its acetate in air[German Research Foundation (DFG)]
BrandbekämpfungsverfahrenTO FIGHT FIRE, USE ALCOHOL FOAM, CO2, DRY CHEMICAL.If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.
LagerbedingungenMATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ...Keep away from heat and open flame.
Freisetung ohne BrandExcerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:
EntsorgungsverfahrenSRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.
Verschüttetes entsorgenPersonal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Preventive MeasuresSRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors.Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.The worker should immediately wash the skin when it becomes contaminated.For more Preventive Measures (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER ACETATE (8 total), please visit the HSDB record page.
KörperbelastungUrine samples collected from workers at a ceramics and varnish manufacturer contained 2-ethoxyacetic acid (EEA) a primary metabolite of ethylene glycol monoethyl ether acetate(1). Since ethylene glycol monoethyl ether acetate is rapidly deacetylated in blood, excretion of the metabolite EEA has been shown to determine accurately concentrations of ethylene glycol monoethyl ether acetate in humans(1). Concentrations of EEA in urine were determined in 17 ceramics factory workers on a Friday afternoon postshift (44 mg/L) and Monday morning following an exposure free weekend (19.3 mg/L)(2). The calculated half-life of EEA was 74.3 hours(2). Concentrations of EEA were determined in urine of varnish factory workers on a Monday morning preshift and Tuesday postshift respectively for the varnish production area (53.2 mg/L Mon and 53.8 mg/L Tues, n = 12), store (3.1 mg/L Mon and 3.4 mg/L Tues, n = 2), laboratory (4.4 mg/L Mon and 5.1 mg/L Tues, n = 4), and foreman's office (7.7 mg/L Mon and 9.8 mg/L Tues, n = 1)(2). /2-Ethoxyacetic acid/
ZielorganeEyes, respiratory system, gastrointestinal tract, reproductive system, hematopoietic system
ÖkotoxizitätswerteLC50Species: Pimephales promelas (Fathead minnow, weight 148 mg)Conditions: flow-through bioassay, dissolved oxygen 7.4 (4.6-8.8) mg/L, water hardness 44.9 (42.4-46.6) mg/L as CaCO3, pH 6.9-7.7, alkalinity 42.9 (39.6-61.4) mg/L CaCO3, temp: 26.4 + or - 1.4 °CConcentration: 44.0 (43.0-45.1) mg/L for 24 hr /Purity 99%/Conditions: flow-through bioassay, dissolved oxygen 7.4 (4.6-8.8) mg/L, water hardness 44.9 (42.4-46.6) mg/L as CaCO3, pH 6.9-7.7, alkalinity 42.9 (39.6-61.4) mg/L CaCO3, temp: 26.4 + or - 1.4 °C 43.5 (31.4-60.3) mg/L for 48 hr /Purity 99%/Concentration: 42.6 (41.4-43.8) mg/L for 72 hr /Purity 99%/Concentration: 42.2 (40.7-43.6) mg/L for 96 hr /Purity 99%/For more Ecotoxicity Values (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER ACETATE (11 total), please visit the HSDB record page.
UmweltverhaltenTERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 32(SRC), determined from a measured Kow of 0.24(2) and a regression-derived equation(3), indicates that ethylene glycol monoethyl ether acetate will have very high mobility in soil(SRC). Volatilization of ethylene glycol monoethyl ether acetate from moist soil surfaces may be an important fate process(SRC) given its Henry's Law constant of 3.2X10-6 atm-cu m/mole(4). Ethylene glycol monoethyl ether acetate is expected to volatilize from dry soil surfaces(SRC) based on its vapor pressure of 2.00 mm Hg(5). Several screening biodegradation tests have demonstrated that ethylene glycol monoethyl ether acetate is readily biodegradable(6-9)80% biodegradation was measured for ethylene glycol monoethyl ether acetate in a 20 day screening test(7) suggesting that biodegradation may be an important fate process in soil(SRC).AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 32(SRC), using a log Kow of 0.24(2) and a regression-derived equation(1), indicates that ethylene glycol monoethyl ether acetate should not adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces may occur(1) based on a Henry's Law constant of 3.2X10-11 atm-cu m/mole(3). Using this Henry's Law constant and an estimation method(1), volatilization half-lives for a model river and model lake are 13 and 100 days, respectively(SRC). According to a classification scheme(4),an estimated BCF value of 3.0(SRC), determined from its log Kow(2), suggests that bioconcentration in aquatic organisms is low(SRC). Biodegradation of ethylene glycol monoethyl ether acetate in a 28 day river die-away test resulted in classification as easily degraded(5) and 80% biodegradation occurred in a 20 day screening test(6) which suggest biodegradation as an important environmental fate process in water(SRC). This compound is expected to hydrolyze with estimated half-lives of 305 and 30 days at pH values of 7 and 8, respectively(7).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene glycol monoethyl ether acetate, which has a measured vapor pressure of 2.00 mm Hg at 25 °C(2), will exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylene glycol monoethyl ether acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be about 0.7 days(SRC), calculated from its measured rate constant of 1.3X10-11 cu cm/molecule-sec at 25 °C(3). Ethylene glycol monoethyl ether acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).
Unerwünschte WirkungenNeurotoxin - Acute solvent syndrome
ExpositionspfadeThe substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact
ToxizitätsübersichtOn the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Ethoxyethanol and Ethoxyethanol Acetate are unsafe for use in cosmetic products.The ingredient is unsafe for use in cosmetics... The methyl and ethyl ethers of ethylene glycol, ie 2- methoxyethanol (2-ME) esters, 2-methoxyethyl acetate (2-MEA) and 2-ethoxyethyl acetate (2- EEA) ... are all stable, and are all miscible with (or in the case of 2-EEA very soluble in) water and miscible with a large number of organic solvents. ... The solubility of these glycol ethers in water and their relatively low vapor pressure could result in their build-up in water in the absence of degradation. However, degradation by microorganisms in soil, sewage sludge, and water appears to prevent this possibility. Atmospheric emissions resulting from the use of glycol ethers as evaporative solvents result in the greatest environmental exposure.... Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L. ... Effects on Experimental Animals and In Vitro Test Systems: Systemic toxicity: The toxicity of 2-ME and 2-EE to experimental animals has been much more widely studied than that of 2-MEA and 2-EEA. 2-ME and 2-EE and their acetates have similar lethalities after single exposures and they show low acute lethality whether exposure is via the dermal, oral, or inhalation route. Oral LD60 values for a variety of species range between 900 and 3400 mg/kg body weight for 2-ME, 1400 and 5500 mg/kg for 2-EE, 1250 and 3930 mg/kg for 2-MEA, and 1300 and 5100 mg/kg for 2-EEA. ... 2-EE was found to be teratogenic (in the presence of slight maternal toxicity). Another study reported fetotoxicity but no malformations in rats exposed to 184 or 920 mg 2-EE/cu m, and in rabbits exposed to 644 mg 2-EE/cu m. NOEL values for developmental effects were 37 mg/cu m for rats and 184 mg/cu m for rabbits. Behavioral and neurochemical alterations were seen in the offspring of rats exposed to 368 mg 2-EE/cu m on days 7-13 or 14-20 of gestation. Rats treated by dermal application of 0.25 mL undiluted 2-EE (four times daily on gestation days 7-16) exhibited marked fetotoxicity and a high incidence of malformation in the absence of maternal toxicity. Similar effects were noted following 2-EEA treatment of rats, using the same protocol, at an equimolar dose (0.35 mL, four times daily). Inhalation exposure of rabbits to 2-EEA on gestation days 6-18 produced teratogenic responses at 2176 mg/cu m and 544 mg/cu m in two different studies, the developmental NOEL values in these two studies being 135 mg/m3 and 270 mg/m3. Exposure of rats to 2-EEA on days 6-15 of gestation produced fetotoxicity at 540 mg/cu m and malformation at 1080 mg/cu m. The developmental NOEL was 170 mg/cu m. Effects on humans: Information on the toxic effects of these four glycol ethers on humans is limited. The results from the few case reports and workplace epidemiological studies are consistent with the adverse effects seen in experimental animals. No reports quantifying general population exposure and health effects have been found. ...
Ökotoxizitätsauszüge/AQUATIC SPECIES/.... Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L.
Plant ConcentrationsEmission rates of ethylene glycol monoethyl ether acetate from a variety of woody Mediterranean species during the spring was experimentally determined for Arbutus unedo (10.69 ug/g-hr), Bupleurum fruticosum (8.36 ug/g-hr), Erica arborea (8.13 ug/g-hr), Pinus halepensis (0.26 ug/g-hr), Quercus coccifera (0.18 ug/g-hr), and Q. ilex (3.66 ug/g-hr)each value represents the man of 3 determinations.
Signs and SymptomsDizziness. Drowsiness. Headache. Unconsciousness.MAY BE ABSORBED! Dry skin. Further see Inhalation.Redness.Nausea. Vomiting. Further see Inhalation.irritation eyes, nosekidney damageparalysisIn Animals: reproductive, teratogenic effects
Effluent ConcentrationsThe emission rate of ethylene glycol monoethyl ether acetate into the atmosphere from painting operations at an automotive assembly plant in Janesville, WI was estimated to be 37.9 gallons/hr(1). Emission rates of ethylene glycol monoethyl ether acetate were measured for a new vehicle (4.4 ug/hr), 20 day old vehicle (1.4 ug/hr) and a 40 day old vehicle (1.3 ug/hr)(mean of n = 6 different new cars)(2). Emission rates of ethylene glycol monoethyl ether acetate from poly vinyl chloride (PVC) cushions were measured for a 3 day old cushion (7 ug/cu m-hr) and a 28 day old cushion (4 ug/cu m-hr)each value represents the mean of 10 determinations(3).
ICSC Environmental DataThe substance is harmful to aquatic organisms.
LuftstandardsThis action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethylene glycol monoethyl ether acetate is produced, as an intermediate or final product, by process units covered under this subpart.
Berufliche Expositionsstufe (OEB)B
Arbeitsplatzgrenzwert (OEL)TWA: 0.5 ppm (2.7 mg/m3) [skin]
Wassergefährdungsklasse (WGK)1
Sofort lebensgefährliche Konzentration500 ppm
TSCA-Inventar-StatusTSCA listed
UN-TransportnummerUN 1172
Zollcode2915 39 00
RTECS-Nr.KK8225000
R-Sätze (R)60-61-20/21/22-10
ToxizitätAcute oral LD50 for guinea pigs 1,910 mg/kg, rats 2,900 mg/kg, rabbits 1,950 mg/kg (quoted, RTECS, 1985).
GefahrensymboleT
Sicherheitshinweise (S)53-45
Gefahrenklasse3Acute Tox. 4 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralFlam. Liq. 3Repr. 1B
VerpackungsgruppeIII
Lagerklasse3 - Flammable liquids
Gefahrstoffdaten111-15-9(Hazardous Substances Data)
Selbstentzündungstemperatur715 °F

Anwendungen & Verwendung

Verwenden

Solvent for nitrocellulose, oils, and resins; retards “blushing” in lacquers, varnish removers, wood stains, textiles, and leather.