2,2'-[Ethan-1,2-diylbis(oxy)]bisethyldiacetat

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.；SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.；INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.；INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.；STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it in a refrigerator. (NTP, 1992)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Triethylene glcol diacetate is exempted from the requirement of a tolerance when used as a solvent (limit: for use on beef cattle only) in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 20(SRC), determined from an estimated log Kow of -0.14(2,SRC) and a regression-derived equation(3), indicates that triethylene glycol, diacetate is expected to have very high mobility in soil(SRC). Volatilization of triethylene glycol, diacetate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.7X10-13 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Triethylene glycol, diacetate is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 4.1X10-3 mm Hg(SRC), determined from a fragment constant method(5). Biodegradation of triethylene glycol, diacetate may be important(SRC), based upon 100% biodegradation of 2-(2-butoxyethoxy)ethyl acetate(6), a structurally similar compound.

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 20(SRC), determined from an estimated log Kow of -0.14(2,SRC) and a regression-derived equation(3), indicates that triethylene glycol, diacetate is not expected to adsorb to suspended solids and sediment in water(SRC). Triethylene glycol, diacetate is not expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 2.7X10-13 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 0.46(3,SRC), from an estimated log Kow(2,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Estimated hydrolysis half-lives of 150 and 15 days at pHs 7 and 8, respectively(6), suggest that hydrolysis is expected to be a slow process(SRC). Biodegradation of triethylene glycol, diacetate may be important(SRC), based upon 100% biodegradation of 2-(2-butoxyethoxy)ethyl acetate(7), a structurally similar compound.

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triethylene glycol, diacetate, which has an estimated vapor pressure of 4.1X10-3 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase triethylene glycol, diacetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 12 hours(3,SRC).

The Koc of triethylene glycol, diacetate is estimated as approximately 20(SRC), using a measured log Kow of -0.14(1) and a regression-derived equation(2,SRC). According to a classification scheme(3), this estimated Koc value suggests that triethylene glycol, diacetate is expected to have very high mobility in soil(SRC).

An estimated BCF of 0.46 was calculated for triethylene glycol, diacetate(SRC), using an estimated log Kow of -0.14(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for triethylene glycol, diacetate is estimated as 2.7X10-13 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that triethylene glycol, diacetate is expected to be essentially nonvolatile from water surfaces(2,SRC). Triethylene glycol, diacetate's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces is not expected to occur(SRC). Triethylene glycol, diacetate is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 4.1X10-3 mm Hg(SRC), determined from a fragment constant method(3).

IT IS...LOW IN SINGLE-DOSE TOXICITY WHEN INJECTED IP, SINCE THE LD50 FOR RATS IS 1.41 ML/KG. ...EYE CONTACT SHOULD GIVE RISE TO NO SIGNIFICANT IRRITATION NOR IS IT LIKELY TO BE ABSORBED THROUGH THE SKIN IN TOXIC AMOUNTS...

A SINGLE 8-HR EXPOSURE OF RATS TO ESSENTIALLY SATURATED VAPORS GENERATED AT APPROX 20 °C RESULTED IN NO SIGNIFICANT ADVERSE EFFECTS.

Triethylene glycol and two of its derivatives were evaluated for reproductive toxicity in a continuous breeding protocol with Swiss CD-1 mice. Triethylene glycol (TEG: 0, 0.3, 1.5, and 3%), triethylene glycol diacetate (TGD: 0, 0.75, 1.5, and 3%), and triethylene glycol dimethyl ether (triethylene glycol dimethyl ether: 0, 0.25, 0.5, and 1%) were administered in drinking water to breeding pairs (20 pairs per treatment groups, 40 control pairs) during a 98-day cohabitation period. Reproductive function was assessed by the number of litters per pair, live pups per litter, proportion of pups born alive, and pup weight. There were no apparent effects on reproductive function in the animals receiving triethylene glycol or triethylene glycol diacetate at doses up to 3% in the drinking water (representing 6.78 or 5.45 g/kg, respectively). However, some developmental toxicity was demonstrated for both triethylene glycol and triethylene glycol diacetate. Continuous exposure of dams to 1.5 or 3% triethylene glycol significantly reduced live pup weight at birth compared to control and 0.3% triethylene glycol significantly reduced live pup weight at birth compared to control and 0.3% triethylene glycol. while exposure to 3% triethylene glycol diacetate during lactation significantly (but reversibly) reduced pup body weights on Postnatal Days 14 and 21. In contrast, triethylene glycol dimethyl ether was toxic to the reproductive system as evidenced by decreases at the highest does (1% triethylene glycol dimethyl ether; 1.47 g/kg) in the proportion of pairs that produced at least one litter, live pups per litter, and proportion of pups born alive, with dose-related trends seen in the latter two parameters. A crossover mating trial showed that triethylene glycol dimethyl ether was more toxic to the female than the male reproductive system. These data indicate that triethylene glycol dimethyl ether (1.47 g/kg) is a reproductive toxicant in Swiss mice while reproductive toxicity was

The rate constant for the vapor-phase reaction of triethylene glycol, diacetate with photochemically-produced hydroxyl radicals has been estimated as 3.2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 12 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). A base-catalyzed second-order hydrolysis rate constant of 0.53 L/mol-sec (SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 150 and 15 days at pH values of 7 and 8, respectively(2,SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 4,322 workers (356 of these are female) are potentially exposed to triethylene glycol, diacetate in the US(1). Occupational exposure to triethylene glycol, diacetate may occur through dermal contact with this compound at workplaces where triethylene glycol, diacetate is produced or used(SRC).

Triethylene glycol, diacetate's production and use as a plasticizer may result in its release to the environment through various waste streams. If released to air, triethylene glycol, diacetate is expected to exist solely as a vapor in the ambient atmosphere based upon an estimated vapor pressure of 4.1X10-3 mm Hg at 25 °C. Vapor-phase triethylene glycol, diacetate will be readily degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals with an estimated half-life of 12 hours. If released to soil, an estimated Koc of 20 suggests that triethylene glycol, diacetate is expected to have very high mobility. Volatilization from wet and dry soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 2.7X10-13 atm-cu m/mol and this compound's estimated vapor pressure, respectively. If released into water, this compound is not expected to adsorb to suspended solids and sediment in the water column based upon its estimated Koc. Triethylene glycol, diacetate is not expected to volatilize from water surfaces based on the estimated Henry's Law constant. An estimated BCF of 0.46 suggests the potential for bioconcentration in aquatic organisms is low. Estimated hydrolysis half-lives of 150 and 15 days at pHs 7 and 8, respectively, indicate that hydrolysis is expected to be a slow process. Biodegradation of triethylene glycol, diacetate may be important, based upon 100% biodegradation of 2-(2-butoxyethoxy)ethyl acetate, a structurally similar compound. Occupational exposure to triethylene glycol, diacetate may occur through dermal contact with this compound at workplaces where triethylene glycol, diacetate is produced or used. (SRC)

Triethylene glycol diacetate (TGDA) was tested in the Reproductive Assessment by Continuous Breedng (RACB) protocol using Swiss CD-1 mice, ... Data gathered on body weights, clinical signs, & food & water consumption during the Task 1 dose-range-finding study were used to select concns for the continuous breeding phase (Task 2) of 0.0, 0.75%, 1.5%, & 3% /weight/volume/ in drinking water. These concns produced calculated consumption estimates of nearly equal to 1.31, 2.62, & 5.25 g/kg/day. Continuous exposure of adult F0 mice to these concns of TGD had no effect on the number of litters/pair, or the number or weight of live pups/litter. The proportion of pups born alive was not affected by these concns of TGDA. Since no effects were observed in Task 2, Task 3, which determines the effected sex, was not conducted. The last litter from Task 2 was nursed until weaning, & then given water containing TGDA at the same concn as their parents. Only the control & 3% TGDA groups were assessed in a second generation. Although viability was not adversely affected, pups nursed by dams receiving 3% TGDA weighed between 15 & 25% less than their controls at /postnatal day/ 14 & 21. These differences in body weight had disappeared by the time of Task 4 mating at nearly equal to /postnatal day/ 74. In the second generation mating trial, there were no treatment-related effects on mating or fertility indices, or on the number of F2 pups, their viability, or weight adjusted for litter size. After the F2 litters were delivered & evaluated, the F1 adults were killed & necropsied. There were no TGDA-related differences in body weight for either sex. In males & females, relative kidney weight was increased by nearly equal to 6-8%. No other treatment-related effects were found. Epididymal sperm concn, motility, & morphology were unaffected by 3% TGDA consumption. These data show that triethylene glycol diacetate had no detectable reproductive toxicity in Swiss mice at exposure levels that alt

Chemical: Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, diacetate

Status: Active Update: 29-03-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/13731

Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, diacetate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Triethylene glycol diacetate is included on this list.

Triethylene glcol diacetate is exempted from the requirement of a tolerance when used as a solvent (limit: for use on beef cattle only) in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals.