HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Butoxy-ethanol
BUTYL GLYCOL · BUTYL CELLOSOLVE · ETHYLENE GLYCOL MONOBUTYL ETHER · Ethanol, 2-butoxy- · BUTOXYETHANOL · BUTYL OXITOL · ETHYLENE GLYCOL BUTYL ETHER · GLYCOL ETHER EB
Identifikatoren & physikalische Daten
| CAS No. | 111-76-2 |
|---|---|
| Summenformel | C6H14O2 |
| Durchschnittliche Molmasse | 118,17 g/mol |
| Monoisotopische Masse | 118,09937969 g/mol |
| SMILES | CCCCOCCO |
| InChIKey | POAOYUHQDCAZBD-UHFFFAOYSA-N |
| PubChem CID | 8133 |
| ChEMBL | CHEMBL284588 |
| ChEBI | CHEBI:63921 |
| EC No. | 203-905-0 |
| DTXSID | DTXSID1024097 |
| Lokaler Name | 2-Butoxy-ethanol |
Chemische & physikalische Eigenschaften
| XLogP | 0,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 29,5 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 5 |
| Schwere Atome | 8 |
| Formalladung | 0 |
| Komplexität | 37,5 |
| Stoffklassen | Carcinogens |
| Solvents | Solvents -> Glycol Ethers (E Series) |
| Kosmetika | Cosmetic ingredients (Butoxyethanol) -> CIR (Cosmetic Ingredient Review)Solvent |
| SpringerMaterials Properties | Boiling point |
| Duftstoffe | Fragrance Ingredient (Ethylene glycol monobutyl ether) -> IFRA transparency List |
| Pestizide | Pesticide -> EPA IRIS |
| LogP (Verteilungskoeffizient) | log Kow = 0.830.830 |
| Geruch | Mild, ether-like odorSlight, rancid odorWeak, pleasant odorCharacteristicquality: sweet, esterhedonic tone: pleasant |
| Lebensmittelzusatzstoffe | WASHING OR SURFACE REMOVAL AGENT -> FDA Substance added to food |
| Dichte | 0.902 at 68 °F (USCG, 1999) - Less dense than waterwill float0.9015 at 20 °CRelative density (water = 1): 0.900.9012 @ 20°C0.902 g/mL at 25 °C(lit.) |
| Aromastoffe | EU Flavoring substances |
| Viscosity | 3.15 centistokes at 25 °C |
| Schmelzpunkt | -70 °C |
| Siedepunkt | 171 °C |
| Dampfdichte | 4.1 (vs air) |
| Dampfdruck | <1 mm Hg ( 20 °C) |
| Brechungsindex | n20/D 1.419(lit.) |
| Flammpunkt | 140 °F |
| Lagerbedingungen | Store below +30°C. |
| Löslichkeit | 900g/l completely miscible |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | 14.42±0.10(Predicted) |
| Farbe | Clear |
| pH | 7 (H2O, 20℃)(as aqueous solution) |
| Geruch | Mild, characteristicslightly rancidmild ethereal. |
| Geruchsschwelle | 0.043ppm |
| Explosionsgrenze | 1.1-10.6%(V) |
| Spezifische Wärmekapazität | Cp(liquid): 2.38 J/(g·K), at 25℃ |
| Merck | 14,1559 |
| BRN | 1732511 |
| Henry-Konstante | (x 10-6 atmm3/mol): 2.36 (approximate - calculated from water solubility and vapor pressure) |
| Dielektrizitätskonstante | 5.2999999999999998 |
| Kosmetik-Inhaltsstoffe Funktionen | SOLVENTFRAGRANCEVISCOSITY CONTROLLING |
| InChI | 1S/C6H14O2/c1-2-3-5-8-6-4-7/h7H,2-6H2,1H3 |
| InChIKey | POAOYUHQDCAZBD-UHFFFAOYSA-N |
| SMILES | CCCCOCCO |
| LogP (Verteilungskoeffizient) | 0.81 at 20℃ |
| CAS Datenbank | 111-76-2(CAS DataBase Reference) |
| NIST chemische Informationen | 2-n-Butoxy-1-ethanol(111-76-2) |
| EPA chemische Informationen | Ethylene glycol monobutyl ether (111-76-2) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH302: Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.4% (13 of 3076) of reports.H302 (99.5%): Harmful if swallowed [Warning Acute toxicity, oral] |
|---|---|
| Regulatorische Informationen | Chemical: Poly(oxy-1,2-ethanediyl), .alpha.-butyl-.omega.-hydroxy-Chemical: Ethanol, 2-butoxy-Hazard Traits - NeurotoxicityRespiratory ToxicityCommission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)Ethanol, 2-butoxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanol, 2-butoxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)FRI - indicates a polymeric substance containing no free-radical initiator in its Inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used. |
| Weitere Sicherheitsinformationen | PEC / SN / Other assessments - 2-Butoxyethanol in cleaning products: Health and Environment |
| DOT-Kennzeichnung | Flammable Liquid |
| Brandgefahren | Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:Combustible. Above 60 °C explosive vapour/air mixtures may be formed. |
| Brandpotenzial | Combustible liquid when exposed to hear or flame. |
| Gesundheitsgefahren | Vapors irritate eyes and nose. Ingestion or skin contact causes headache, nausea, vomiting, dizziness. (USCG, 1999) |
| Gefahrenübersicht | Severe hemoglobinuria and changes in the lungs, kidneys, and liver are seen in mice after 7-hour lethal concentration studies. Volunteers showed no evidence of adverse effects other than mucous membrane irritation after 8 hour exposures to 200 ppm. No increase in red cell fragility was seen after these brief exposures. [ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] Humans are resistant to butoxyethanol-induced red blood cell hemolysis. [Sullivan, p. 1204] See Glycol ethers. |
| DOT-Nummer und Handbuch | 2369 152 |
| FDA-Anforderungen | Ethylene glycol monobutyl ether is an indirect food additive for use only as a component of adhesives. |
| Reaktive Gruppe | Alcohols and Polyols |
| UN-Einstufung | UN Hazard Class: 6.1UN Pack Group: III |
| Special Reports | Jaraczewska W et alToxicology of butyl glycolMed Pr 30 (5) 353 (1979). A review on the toxicity of butyl ethylene glycol, especially its CNS depressant effect & action inducing parenchymatous organ lesions.USEPAHealth effects assessment for glycol ethers pp 90 (1984) EPA/540/1-86/052Johanson GAspects of biological monitoring of exposure to glycol ethersToxicol Lett 43 (1-3): 5-21 (1988)Miller RRMetabolism and Disposition of Glycol EthersDrug Metab Rev 18 (1): 1-22 (1987).For more Special Reports (Complete) data for ETHYLENE GLYCOL MONO-N-BUTYL ETHER (8 total), please visit the HSDB record page. |
| Brandbekämpfung | Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention . |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.(General first aid procedures) |
| Sichere Lagerung | Separated from strong oxidants and food and feedstuffs. Cool. Keep in the dark. |
| Expositionsschutz und Persönliche Schutzausrüstung | Biological Exposure Indices (BEI) [ACGIH] - Butoxyacetic acid (BAA) in urine (with hydrolysis) = 200 mg/g creatinine at end of shift.2824.0 [ppm]10.0 [ppm], sum of the concentrations of EGBE and its acetate in air[German Research Foundation (DFG)] |
| Brandbekämpfungsverfahren | Carbon dioxide or dry chemical for small firesalcohol-type foam for large fires.If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources./To fight fire use:/ Powder, alcohol-resistant foam, water spray, carbon dioxide. Keep drums, etc., cool by spraying with water. |
| Lagerbedingungen | Separated from strong oxidants, food and feedstuffs. Cool. Keep in the dark |
| Reinigungsverfahren | Ventilate area of spill or leak. For small quantities, absorb on paper towels. Evaporate in safe place (such as fume hood). Allow sufficient time for evaporating vapors to completely clear hood ductwork. Burn paper in suitable location away from combustible materials. Large quantities can be collected and atomized in suitable combustion chamber. Waste disposal: By absorbing it in vermiculite, dry sand, earth or similar material and disposing in secured sanitary landfillBy atomizing in suitable combustion chamber.In simulated waste gas containing 1000 ppm ethylene butyl monobutyl ether was absorbed by spindle oil 88 containing calcium naphthanate, a nonionic surfactant, antioxidant, and a stabilizer.Activated sludge decomposed organic solvents contained in absorbing liquid of waste gas from painting booths. Ethylene glycol monobutyl ether was decomposed by acclimated sludge.Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.For more Cleanup Methods (Complete) data for ETHYLENE GLYCOL MONO-N-BUTYL ETHER (6 total), please visit the HSDB record page. |
| Freisetung ohne Brand | Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: |
| Entsorgungsverfahren | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.n-Butoxy ethanol should be atomized into an incinerator, and combustion may be improved by mixing with a more flammable solvent.The following wastewater treatment technologies have been investigated for Ethylene glycol monobutyl ether: Concentration process: Activated carbon. |
| Verschüttetes entsorgen | Personal protection: protective clothing, protective gloves and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.The worker should immediately wash the skin when it becomes contaminated.Work clothing that becomes wet or significantly contaminated should be removed and replaced.For more Preventive Measures (Complete) data for ETHYLENE GLYCOL MONO-N-BUTYL ETHER (6 total), please visit the HSDB record page. |
| Körperbelastung | At 2 bicycle manufacturing factories, 31 decal transfer workers whose hands were in direct contact with a dilute aqueous solution of ethylene glycol mono-n-butyl, were exposed to an average of 1.7 ppm (8.1 mg/cu m) of ethylene glycol mono-n-butyl in air. Although correlation of ethylene glycol mono-n-butyl in air and its major metabolite (2-butoxyacetic acid)in postshift urinary levels was poor, postshift total 2-butoxyacetic acid levels in urine on Monday and Friday were 446.8 and 619.4 mg/g creatinine, respectively(1).Urinary concentrations of ethylene glycol mono-n-butyl ether were reported in 6 workers that used ethylene glycol mono-n-butyl ether as a solvent in the polymerization of a resin at a semiconductor factory. The workers ethylene glycol mono-n-butyl ether concentration in urine(1). The average preshift and postshift urinary concentrations of 12 varnish production facility workers was 53.2 and 53.8 mg/L with a range of 2.3-180.0 and 11.1-143.7 mg/L, respectively. The population with the highest concentration was workers involved directly in varnish production(2). |
| Wechselwirkungen | The kinetics of (14)C-2-butoxyethanol metabolism and clearance were studied in control adult (3-4 months old) and old (12-13 months old) male F344 and in adult male F344 rats treated with pyrazole, cyanamide or probenecid. The area under the curve, maximum plasma concentration and systemic clearance of 2-butoxyethanol were dose-dependent. In contrast, there was no effect of dose on half-life (T1/2) or volume of distribution of 2-butoxyethanol. There was no age effect on T1/2, volume of distribution, or systemic clearance of 2-butoxyethanol. However, maximum plasma concentration and area under the curve of 2-butoxyethanol increased as a function of age. Inhibition of 2-butoxyethanol metabolism by pretreatment of rats with pyrazole or cyanamide resulted in an increase in the T1/2 and area under the curve of 2-butoxyethanol, whereas it caused a decrease in the systemic clearance. Furthermore, pyrazole had no effect, whereas cyanamide had decreased volume of distribution of 2-butoxyethanol.Ethanol (20 mmol/kg bw (920 mg/kg bw)) and 2-butoxyethanol (2.5 mmol/kg bw (295 mg/kg bw)) were co-administered intraperitoneally to female Sprague-Dawley ratsblood levels of 2-butoxyethanol were nearly constant as long as blood ethanol levels were above 3 mM (138 ug/mL). This level of ethanol inhibited the metabolism of 2-butoxyethanol by alcohol dehydrogenase, the enzyme that is common to ethanol and 2-butoxyethanol. |
| Zielorgane | HematologicEyes, skin, respiratory system, central nervous system, hematopoietic system, blood, kidneys, liver, lymphoid system |
| Ökotoxizitätswerte | LC50Species: Menidia beryllina (Inland silverside)Conditions: staticConcentration: 1250 mg/L for 96 hrSpecies: Crangon crangon (brown shrimp)Concentration: 800 mg/L for 48 hr (range: 600-1000 mg/L) /Conditions of bioassay not specified in source examined/Concentration: 775 mg/L for 96 hr (range: 550-950 mg/L) /Conditions of bioassay not specified in source examined/Species: Poecilia reticulata (Guppy)Concentration: 983 mg/L for 7 days /Conditions of bioassay not specified in source examined/For more Ecotoxicity Values (Complete) data for ETHYLENE GLYCOL MONO-N-BUTYL ETHER (16 total), please visit the HSDB record page. |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 8(SRC), determined from a log Kow of 0.83(2), indicates that ethylene glycol mono-n-butyl ether is expected to have very high mobility in soil(SRC). Volatilization of ethylene glycol mono-n-butyl ether from moist soil surfaces is expected to be an important fate process(SRC) given an Henry's Law constant of 1.60X10-6 atm-cu m/mole(3). Ethylene glycol mono-n-butyl ether is expected to volatilize slowly from dry soil surfaces(SRC) based upon a vapor pressure of 0.88 mm Hg(4). Ethylene glycol mono-n-butyl ether reached 96% of its theoretical BOD in 14 days using an activated sludge inoculum(5). Therefore this compound is expected to biodegrade rapidly in the soil environment.AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 8(SRC), determined from a log Kow of 0.83(2), indicates that ethylene glycol mono-n-butyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.6X10-6 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 17 and 185 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3, from its log Kow of 0.83(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Alcohols and ethers are generally resistant to hydrolysis(7). Ethylene glycol mono-n-butyl ether reached 96% of its Theoretical BOD in 14 days using an activated sludge inoculum(8). Therefore this compound is expected to biodegrade rapidly in the aquatic environment.ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene glycol mono-n-butyl ether, which has a vapor pressure of 0.88 mm Hg at 25 °C(2) is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylene glycol mono-n-butyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 15 hours(SRC), calculated from its rate constant of 1.86X10-11 cu cm/molecule-sec at 25 °C(3). Ethylene glycol mono-n-butyl ether does not contain chromophores that absorb at wavelengths >290 nm(4), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). |
| Lebensmitteluntersuchungswerte | Ethylene glycol mono-n-butyl ether has been qualitatively identified in the volatile fraction of raw beef(1,2).Ethylene glycol mono-n-butyl ether was detected at 99.2 micrograms/kg (99.2 ppb) in one of three samples of fermented soybean curds collected from a Hong Kong market(1). Ethylene glycol mono-n-butyl ether was detected in raw but not roasted earth-almonds (Cyperus esculentus L.) collected in Valencia, Spain(2). The detected concentrations were not presented(2). Ethylene glycol mono-n-butyl ether was detected as it was released from frankfurters (50 g samples) during steam distillation(3). The amount of ethylene glycol mono-n-butyl ether that was released varied among frankfurters with different fat contents, although not linearly(3). Relative chromatographic peak areas, not concentrations, were presented(3). Ethylene glycol mono-n-butyl ether was detected in raw beef extracted by supercritical fluid extraction with carbon dioxide(4). The ethylene glycol mono-n-butyl ether was detected in a volatile fraction and none was detected in the condensed, lipid fraction(4). Relative chromatographic peak areas, not concentrations, were presented(4). Ethylene glycol mono-n-butyl ether was detected in cooked mussels collected in France(5). The concentrations of ethylene glycol mono-n-butyl ether detected in tissue or volatile fraction emitted by the mussels were not reported(5). |
| Unerwünschte Wirkungen | Neurotoxin - Acute solvent syndrome |
| Expositionspfade | The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
| Toxizitätsübersicht | On the basis of the animal and clinical data included in this report, the Expert Panel concludes that Butoxyethanol is safe in hair and nail products at concentrations up to 10.0%. Note: In 2002, the CIR Expert Panel considered available new data on this ingredient and reaffirmed the above conclusion.Safe for use in cosmetics, with qualifications2-Butoxyethanol is a high production volume glycol ether. It is a colorless liquid that is miscible in water and soluble in most organic solvents. 2-Butoxyethanol is used widely as a solvent in surface coatings, such as spray lacquers, quick dry lacquers, enamels, varnishes, varnish removers and latex paint. Based on limited data, ambient exposures in air are generally in the ug/cu m range. Industrial exposure of the general population to this chemical is most likely from inhalation and dermal absorption during the use of products containing 2-butoxyethanol. Levels of airborne 2-butoxyethanol in occupational settings are typically in the mg/cu m range. The results of in vitro studies indicate that human red blood cells are not as sensitive to the hemolytic effects of 2-butoxyethanol and 2-butoxyacetic acid and also that red blood cells are more sensitive to hemolysis by 2-butoxyacetic acid than to hemolysis by 2-butoxyethanol. 2-Butoxyethanol is readily absorbed following inhalation, oral or dermal exposure. The chemical is metabolized via alcohol and aldehyde dehydrogenases, with the formation of 2-butoxyacetaldehyde and 2-butoxyacetic acid, the principal metabolite, although other metabolic pathways have also been identified. This chemical has moderate acute toxicity and it is irritating to the eyes and skinit is not a skin sensitizer. The principal effect exerted by 2-butoxyethanol and its metabolite 2-butoxyacetic acid is hematotoxicity, with the rat being the most sensitive species. In rats, adverse effects on the central nervous system, kidneys and liver occur at higher exposure concentrations than do the hemolytic effects. In animals, adverse effects on reproduction and development have not been observed at less than toxic doses. Although the results of in vitro tests for mutagenicity of 2-butoxyethanol were inconsistent, the absence of structural alerts and the negative findings from in vivo studies indicate that 2-butoxyethanol is not mutagenic. |
| Average Daily Intake | The average daily intake of ethylene glycol mono-n-butyl estimated from measuring emission rates from 13 household cleaners. The estimated average daily inhalation exposure level for 2 all-purpose spray cleaners was 0.075 and 0.186 mg/kg body wt. per day and 0.004 and 0.006 for 2 spray glass cleaners(1). |
| Signs and Symptoms | Cough. Dizziness. Drowsiness. Headache. Nausea. Weakness.MAY BE ABSORBED! Dry skin. Further see Inhalation.Redness. Pain. Blurred vision.Abdominal pain. Diarrhoea. Further see Inhalation.irritation eyes, skin, nose, throathemolysis, hematuria (blood in the urine)central nervous system depression, headachevomiting |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=111-76-2] |
| TSCA-Anforderungen | Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 2-Butoxyethanol is included on this list. Effective date: 4/13/89Sunset date: 6/30/98. |
| FIFRA-Anforderungen | Residues of ethylene glycol monobutyl ether are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (c) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-processing equipment and utensils. Ethanol, 2 butoxy- is included on this list.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Butoxyethanol is found on List C. Case No: 3036Pesticide type: fungicide, antimicrobialCase Status: No products containing the pesticide are actively registered. Therefore, we are characterizing the case as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.Active ingredient (AI): butoxyethanolAI Status: The active ingredient is no longer contained in any registered products. Thus, we characterize it as "cancelled.". |
| Luftstandards | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethylene glycol monobutyl ether is produced, as an intermediate or a final product, by process units covered under this subpart. |
| Landesrichtlinien für Trinkwasser | (ME) MAINE 3,500 ug/l |
| Berufliche Expositionsstufe (OEB) | A |
| Arbeitsplatzgrenzwert (OEL) | TWA: 5 ppm (24 mg/m3) [skin] |
| Wassergefährdungsklasse (WGK) | 1 |
| Sofort lebensgefährliche Konzentration | 700 ppm |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | 1986 |
| Zollcode | 2909 43 00 |
| RTECS-Nr. | KJ8575000 |
| R-Sätze (R) | 20/21/22-36/38 |
| Toxizität | LD50 orally in rats: 1.48 g/kg (Smyth) |
| Gefahrensymbole | Xn |
| Sicherheitshinweise (S) | 36/37-46 |
| Gefahrenklasse | 6.1Acute Tox. 3 InhalationAcute Tox. 4 OralEye Irrit. 2Skin Irrit. 2 |
| Verpackungsgruppe | III |
| Lagerklasse | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
| Gefahrstoffdaten | 111-76-2(Hazardous Substances Data) |
| Selbstentzündungstemperatur | 473 °F |
Anwendungen & Verwendung
Beschreibung
2-Butoxyethanol is a clear, colourless liquid with ether-like smell.2-Butoxyethanol is usually produced by a reaction of ethylene oxide with butyl alcohol, but it may also be made by the reaction of ethylene glycol with dibutyl sulphate. 2-Butoxyethanol is widely used as a solvent in protective surface coatings such as spray lacquers, quick-dry lacquers, enamels, varnishes, and latex paints. It is also used as an ingredient in paint thinners and strippers, varnish removers, agricultural chemicals, herbicides, silicon caulks, cutting oils, and hydraulic fluids and as metal cleaners, fabric dyes and inks, industrial and household cleaners (as a degreaser), and dry-cleaning compounds. It is also used in liquid soaps and in cosmetics. 2-Butoxyethanol acetate has been reported to be present in air, water, and soil as a contaminant and exposure to it occurs during its manufacture and use as an intermediate in the chemical industry, and during the formulation and use of its products in multiple industrial activities. The acetate form of 2-butoxyethanol is 2-butoxyethanol acetate and also known as ethylene glycol monobutyl ether acetate.