Bis(2-chloroethoxy)methane

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

To fight fire, use alcohol foam, foam, CO2 or dry chemical.

"Alcohol" foam. Water or foam may cause frothing.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

... Materials which are toxic as stored or which can decomp into toxic components due to contact with heat, moisture, acid, or acid fumes, should be stored in cool, well-ventilated place, out of direct rays of sun, away from areas of high fire hazard and should be periodically inspected and monitored.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U024, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids. A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.

Personnel protection: Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.

0.033 [mg/m3]

0.37 [mg/m3]

2.2 [mg/m3]

LC50 Daphnia magna 201 mg/l 48-hr /Conditions of bioassay not specified/

LC50 Pimephales promelas 184 mg/l 96 hr /Conditions of bioassay not specified/

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 32(SRC), determined from a water solubility of 7,800 mg/l(2) and a regression-derived equation(3), indicates that bis(2-chloroethoxy)methane is expected to have very high mobility in soil(SRC). Volatilization of bis(2-chloroethoxy)methane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.9X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 0.132 mm Hg(4), and water solubility, 7,800 mg/l(2). Bis(2-chloroethoxy)methane is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Based upon studies in water(5,6), bis(2-chloroethoxy)methane is not expected to degrade in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 32(SRC), determined from a water solubility of 7,800 mg/l(2) and a regression-derived equation(3), indicates that bis(2-chloroethoxy)methane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.8X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 0.132 mm Hg(4), and water solubility, 7,800 mg/l(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 8.4 and 96 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 4(SRC), from its water solubility(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The hydrolysis half-life for similar beta-chloro ethers has been estimated at 0.5-2 years, a process which is pH independent(7). Bis(2-chloroethoxy)methane is not expected to readily biodegrade in the environment(SRC); bis(2-chloroethoxy)methane underwent 0% biodegradation using a settled domestic wastewater inoculum and biodegradation remained at 0% through three subcultures(8,9).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bis(2-chloroethoxy)methane, which has a vapor pressure of 0.132 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase bis(2-chloroethoxy)methane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.1 days(SRC), calculated from its rate constant of 7.5X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3).

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=111-91-1]

... Has been monitored in rubber plant effluents at a maximum level of 140 mg/l.

Bis(2-chloroethoxy)methane was qualitatively detected in disposal trench leachate samples collected from commercially operated low-level radioactive disposal sites at Maxey Flats, KY, and at West Valley, NY(1). Bis(2-chloroethoxy)methane was detected in 1.0% of 1,243 samples from the USEPA STORET Data Base with a median concn less than 10 ug/l(2). Bis(2-chloroethoxy)methane was detected in 11 of 129 raw water extracts at 11 water utilities in the Ohio River Basin (between 1977-78) at concn less than 0.1 ug/l(3).

The Koc of bis(2-chloroethoxy)methane is estimated as 32(SRC), using a water solubility of 7,800 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that bis(2-chloroethoxy)methane is expected to have very high mobility in soil(SRC).

Bis(2-chloroethoxy)methane underwent 0% biodegradation using settled domestic wastewater as an inoculum; biodegradation remained at 0% through three subcultures. Bis(2-chloroethoxy)methane was thus listed as being not biodegraded under the conditions of the method, the lowest of a three tier rating system(1,2). When the influent to a full scale activated sludge treatment system was spiked with 0.24 ug/l bis(2-chloroethoxy)methane, 60% of the pollutant was removed(3); however, it was not reported if removal was due to biodegradation or some other removal process(SRC).

bis(2-Chloroethoxy)methane

TR-536: Toxicology and Carcinogenesis Studies of bis(2-Chloroethoxy)methane (CASRN 111-91-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies) (2011 )

11/19/09

No Evidence

No Evidence

No Evidence

U024; As stipulated in 40 CFR 261.33, when dichloromethoxy ethane, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Ethane, 1,1'-(methylenebis(oxy))bis(2-chloro- is included on this list.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).