2-(2-Ethoxyethoxy)ethyl acetate

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

2.2 [mg/m3]

24 [mg/m3]

140 [mg/m3]

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from an assigned value for water solubility of 1X10+6 mg/L (miscible)(2) and a regression-derived equation(3), indicates that diethylene glycol monoethyl ether acetate is expected to have very high mobility in soil(SRC). Volatilization of 2-(2-ethyoxyethoxy)ethyl acetate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.3X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 9.89X10-2 mm Hg(4), and assigned value for water solubility(2). Diethylene glycol monoethyl ether acetate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Utilizing the Japanese MITI test, 98-103% of the theoretical BOD was reached over a 4 week incubation period using an activated sludge and an initial chemical concentration of 100 mg/L(5), indicating that biodegradation in soil is an important environmental fate process(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from an assigned value for water solubility of 1X10+6 mg/L (miscible)(2) and a regression-derived equation(3), indicates that diethylene glycol monoethyl ether acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.3X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 9.89X10-2 mm Hg(4), and assigned value for water solubility(2). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Estimated hydrolysis half-lives of 300 and 30 days at pHs 7 and 8, respectively(8), suggest that hydrolysis is only expected to be an important process under alkaline conditions(SRC). Utilizing the Japanese MITI test, 98-103% of the theoretical BOD was reached over a 4 week incubation period using an activated sludge and an initial chemical concentration of 100 mg/L(9), indicating that biodegradation in soil is an important environmental fate process(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylene glycol monoethyl ether acetate, which has a vapor pressure of 9.89X10-2 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylene glycol monoethyl ether acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 13 hours(SRC), calculated from its rate constant of 2.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Diethylene glycol monoethyl ether acetatecontains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).

The Koc of diethylene glycol monoethyl ether acetate is estimated as 10(SRC), using an assigned value for water solubility of 1X10+6 mg/L (miscible)(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diethylene glycol monoethyl ether acetate is expected to have very high mobility in soil.

/HUMAN EXPOSURE STUDIES/ Diethylene glycol monoethyl ether acetate (DGEEA) ... produces only a mild irritation when tested on humans.

/SIGNS AND SYMPTOMS/ Human patch tests, using undiluted material, resulted in limited number of people developing mild skin irritation.

/SIGNS AND SYMPTOMS/ Symptomatology: 1. Central nervous depression... 3. Nausea, vomiting, & sometimes diarrhea. 4. ...Headache. Later abdominal & lumbar pain & costovertebral angle tenderness. 5. Transient polyuria & then oliguria, progressing to anuria. 6. Acute renal failure... /Diethylene glycol & its ether-esters/

/SIGNS AND SYMPTOMS/ Symptomatology: 7. Less critical pathological lesions may appear in brain, lungs, liver, meninges & heart. /Diethylene glycol & its ether-esters/

AEROBIC: Diethylene glycol monoethyl ether acetate, present at 100 mg/L, reached 98 to 103% of its theoretical BOD after 4 weeks using an activated sludge seed at an concentration of 30 mg/L in the Japanese MITI test(1). In a biodegradation study of diethylene glycol monoethyl ether acetate using a settled sewage seed and an initial chemical concentration of 2.5 ppm, diethylene glycol monoethyl ether acetate reached 23.1, 44.0, 82.4, 90.1, 94.6, and 100% of its theoretical BOD after 5, 10, 15, 20, 30, and 40 days, respectively(2). A theoretical BOD of 61% for diethylene glycol monoethyl ether acetate was reached over a period of 10 days in a biodegradation study employing dispersed seed aeration(3).

An estimated BCF of 3 was calculated in fish for diethylene glycol monoethyl ether acetate(SRC), using an estimated log Kow of 0.32(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for diethylene glycol monoethyl ether acetate is estimated as 2.3X10-8 atm-cu m/mole(SRC) derived from its vapor pressure, 9.89X10-2 mm Hg(1), and assigned value for water solubility of 1X10+6 mg/L (miscible)(2). This Henry's Law constant indicates that diethylene glycol monoethyl ether acetate is expected to be essentially nonvolatile from water surfaces(3). Diethylene glycol monoethyl ether acetate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

/LABORATORY ANIMALS: Acute Exposure/ Results of an Organization for Economic Cooperation and Development (OECD) Guideline 406 study in guinea pigs indicate that diethylene glycol ethyl ether acetate caused skin irritation but was not sensitizing

/LABORATORY ANIMALS: Acute Exposure/ Undiluted test material (0.1 ml) was placed in the left eye (under the lid) of 6 male small White Russian, Chbb-SPF rabbits. The right eye was the control. Eyes were washed with warm salt water after 72 hours contact with the test material. They were evaluated 1, 24, 72 hours and 6, 8, 10, 13, 17 and 21 days after treatment. The injury was given a grade of 29.4/110. One animal had irreversible damage to the cornea (defined as not recovering to normal after 21 days).The results at 72 hours were described as moderately irritating.

/LABORATORY ANIMALS: Acute Exposure/ Three male, small White Russian rabbits (2.3- 2.7 g) were used in the study. est material (0.5 ml) was applied to the skin, covered with cloth, and wrapped with an elastic bandage. The dressings were removed after 4 hours and the remaining test material was rinsed away with warm water. The skin reaction was scored 1, 24, 48 and 72 hours and 6, 8, and 10 days after removing the dressing. The maximum possible 1) erythema and eschar and 2) edema scores were 4 each. Erythema scores of 1 (very slight) were obtained in 2 animals at 1, 24, and 48 hours. One of these animals also had an erythema score of 1 at 72 hours and 6 days. One animal had an edema score of 1 (very slight) at 1 hour. Edema was not found in at any other time point. The irritation index was 0.67 /8, which was between the values assigned for a designation of slightly irritating (0.6 - 3.0).

/LABORATORY ANIMALS: Acute Exposure/ Rats & guinea pigs exposed to essentially saturated atmospheres at room temperature for 8 hr all survived, but gross autopsy revealed injury to the lungs & kidneys.

/GENOTOXICITY/ In Ames test Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538 at 8 - 5000 micrograms/plate, no significant increases in the number of revertant colonies were observed following treatment with the test material, either in the absence or presence of S-9. Test material was not toxic at up to 5000 micrograms/plate.

The rate constant for the vapor-phase reaction of diethylene glycol monoethyl ether acetate with photochemically-produced hydroxyl radicals has been estimated as 2.9X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 13 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.26 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 300 and 30 days at pH values of 7 and 8, respectively(2). Diethylene glycol monoethyl ether acetate contains chromophores that absorb at wavelengths >290 nm(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 18,136 workers (4,675 of these were female) were potentially exposed to diethylene glycol monoethyl ether acetate in the US(1). Occupational exposure to diethylene glycol monoethyl ether acetate may occur through inhalation and dermal contact with this compound at workplaces where diethylene glycol monoethyl ether acetate is produced or used. Use data indicate that the general population may be exposed to diethylene glycol monoethyl ether acetate via dermal contact with products containing diethylene glycol monoethyl ether acetate(SRC).

Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date 9/30/91; Reporting date: 11/27/91.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Ethanol, 2-(2-ethoxyethoxy)-, acetate is included on this list. Effective date 9/30/91; Sunset date: 6/30/98.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Diethylene glycol monoethyl ether acetate is produced, as an intermediate or a final product, by process units covered under this subpart.

Used as solvent for cellulose esters, gums, resins, coatings, lacquers, and printing inks; [Hawley]

Painting (Solvents) [Category: Paint]

Solvent for cellulose esters, gums, resins; coatings and lacquers; printing inks.

Solvent, eg, for latex paints, lacquers and printing inks

2023: 1,000,000 - <2,500,000 lb

(1979) Probably greater than 4.54X10+6 g

(1981) Probably greater than 4.54X10+6 g

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#5432]

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#5433]

Ethylene glycol esters are produced from reaction of ethylene oxide and an appropriate acid and are used also as solvents. Use of a suitable catalyst can influence the outcome of the reaction so as to produce monoesters (sodium acetate) or diesters (sulfuric acid). Glycol monoethers can be converted to the corresponding ether esters by the usual methods. /Ethylene glycol esters/

Produced by esterification of diethylene glycol monoethyl ether.

Reaction of diethylene glycol monoethyl ether with acetic acid

Not Known or Reasonably Ascertainable

Ethanol, 2-(2-ethoxyethoxy)-, 1-acetate: ACTIVE