| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 97.2% (2397 of 2467) of all reports.Not ClassifiedAggregated GHS information provided per 2467 reports by companies from 14 notifications to the ECHA C&L Inventory.WarningH335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P271, P304+P340, P319, P403+P233, P405, and P501 (click each P-code to see the statement) |
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| Regulatorische Informationen | Chemical: Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 15-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15468Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-: Does not have an individual approval but may be used under an appropriate group standard |
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| Weitere Sicherheitsinformationen | IMAP assessments - Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-: Human health tier I assessment |
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| Brandgefahren | This chemical is combustible. (NTP, 1992) |
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| Brandpotenzial | Combustible when exposed to heat or flame.... It is stable chemically, does not present hazard due to flammability, except possibly at high temperatures or where fogs or mists are involved. |
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| Gesundheitsgefahren | Vapor and liquid are unlikely to cause harm. (USCG, 1999) |
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| Gefahrenübersicht | No listed effects of short-term or long-term exposure[ICSC] A mild skin and eye irritant based on animal studies[MSDSonline] See Ethylene glycols. |
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| FDA-Anforderungen | Triethylene glycol is an indirect food additive for use only as a component of adhesives. |
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| Reaktive Gruppe | Alcohols and Polyols |
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| Special Reports | Cosmetic Ingredient Review Expert PanelFinal Report on the Safety Assessment of Triethylene Glycol and PEG-4. Int J Toxicol 25 (Supp 2): 121-38 (2006).Ballantyne B and Snellings WMToxicology Update. Triethylene glycol HO(CH2CH3O)3H. J Appl Toxicol 27 (3): 291-9 (2007) reviews existing information on toxicity and related information on triethylene glycol.USEPA/Office of Pesticide ProgramsReregistration Eligibility Decision Document - Triethylene Glycol, EPA 739-R-05-002 (September 2005). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of March 8, 2007: http://www.epa.gov/pesticides/reregistration/status.htm]European Chemicals BureauIUCLID Dataset, Triethylene Glycol (112-27-6) p. 56/99 (2000 CD-ROM edition). Available from the Database Query page at: http://ecb.jrc.it/esis/esis.php as of February 16, 2007. |
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| EPA Safer Chemical | Chemical: Triethylene glycol |
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| FIFRA-Anforderungen | Residues of triethylene glycol are exempted from the requirement of a tolerance when used as a deactivator in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.The Agency has determined triethylene glycol is eligible for reregistration. Based on the available data, the Agency has concluded that triethylene glycol exhibits low toxicity and exposures to triethylene glycol used as both an active or inert ingredient do not present risks of concern to the Agency. Therefore, no mitigation measures are necessary at this time.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Triethylene glycol is found on List C. Case No: 3146Pesticide type: insecticide, fungicide, antimicrobialCase Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.Active ingredient (AI): triethylene glycolData Call-in (DCI) Date(s): 9/30/92AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner. |
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| Reactivity Profile | TRIETHYLENE GLYCOL is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. Reacts with strong oxidants. [Handling Chemicals Safely 1980. p. 932]. |
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| Brandbekämpfung | Fire Extinguishing Agents Not to Be Used: Water or foam may cause frothing.Use water spray, powder, alcohol-resistant foam, carbon dioxide. |
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| Erste-Hilfe-Maßnahmen | Remove contaminated clothes. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. |
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| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
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| Expositionsschutz und Persönliche Schutzausrüstung | 1000.0 [mg/m3], inhalable fraction[German Research Foundation (DFG)] |
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| Brandbekämpfungsverfahren | Alcohol foam, dry chemical |
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| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
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| Entsorgungsverfahren | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations. |
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| Verschüttetes entsorgen | Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
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| Preventive Measures | Air Treatment: Do not use in nurseries or rooms where infants, ill or aged patients are confinedfood, food contact surfaces and utensils should be protected from exposure to the spray or rinsed with ptable water before use. Spray away from drapes, walls, plastic, vinyl, painted or varnished surfaces.SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. |
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| Eye Prevention | Wear safety spectacles. |
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| Fire Prevention | NO open flames. |
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| Inhalation Risk | A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C. |
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| Ökotoxizitätswerte | LC50 Menidia beryllina /(Inland silverside)/ >10,000 ppm/96 hr (static bioassay in synthetic seawater at 23 °C, mild aeration applied after 24 hr).LC50 Pimephales promelas (Fathead minnow) 59.9 g/L/96 hr (confidence limit 56.2 - 63.7 g/L), flow-through bioassay with measured concentrations, dissolved oxygen 7.2 mg/L, hardness 44.2 mg/L calcium carbonate, alkalinity 38.5 mg/L calcium carbonate, and pH 7.3LC50 Pimephales promelas (Fathead minnow) 70.2 g/L/96 hr (confidence limit 68.6 - 71.9 g/L), flow-through bioassay with measured concentrations, 22.2 °C, dissolved oxygen 6.4 mg/L, hardness 45.0 mg/L calcium carbonate, alkalinity 37.7 mg/L calcium carbonate, and pH 7.3LC50 Pimephales promelas (Fathead minnow, mean weight 0.15 g) 77.4 g/L/96 hr (confidence limit 70.7 - 84.8 g/L), flow-through bioassay with measured concentrations, 21.7 °C, dissolved oxygen 4.6 mg/LFor more Ecotoxicity Values (Complete) data for TRIETHYLENE GLYCOL (13 total), please visit the HSDB record page. |
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| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that triethylene glycol is expected to have very high mobility in soil(SRC). Volatilization of triethylene glycol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.2X10-11 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Triethylene glycol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.32X10-3 mm Hg(4). A series of aerobic river die-away tests which utilized several different sources of freshwater, suggest that rapid biodegradation is likely to be the most important removal mechanism of triethylene glycol from aerobic soil(SRC)degradation was complete within 7-11 days(5).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that triethylene glycol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 3.2X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of -1.75(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A series of aerobic river die-away tests, which utilized several differing sources of freshwater, suggest that rapid aerobic biodegradation is likely to be the most important removal mechanism of triethylene glycol from aquatic systems(SRC)degradation was complete within 7-11 days(8).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triethylene glycol, which has a vapor pressure of 1.32X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase triethylene glycol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 11 hours(SRC), calculated from its rate constant of 3.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Alcohols and ethers do not absorb light at wavelengths >290 nm and therefore triethylene glycol is not expected to be susceptible to direct photolysis by sunlight(4). |
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| Expositionspfade | The substance can be absorbed into the body by inhalation of its vapour. |
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| Toxizitätsübersicht | Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgTriethylene glycol (TEG) is a liquid higher glycol of very low vapor pressure with uses that are primarily industrial. It has a very low order of acute toxicity by iv, ip, peroral, percutaneous and inhalation (vapor and aerosol) routes of exposure. It does not produce primary skin iritation. Acute eye contact with the liquid causes mild local transient irritation (conjunctival hyperemia and slight chemosis) but does not induce corneal injury. Animal maximization and human volunteer repeated insult patch tests studies have shown that TEG does not cause skin sensitization. A study with Swiss-Webster mice demonstrated that TEG aerosol has properties of a peripheral chemosensory irritant material and caused a depression of breathing rate with an RD(50) of 5140 mg/ cu m. Continuous subchronic peroral dosing of TEG in the diet of rats did not produce any systemic cumulative or long-term toxicity. The effects seen were dose-related increased relative kidney weight, increased urine volume and decreased urine pH, probably a result of the renal excretion of TEG and metabolites following the absorption of large doses of TEG. There was also decreased hemoglobin concentration, decreased hematocrit and increased mean corpuscular volume, probably due to hemodilution following absorption of TEG. The NOAEL was 20,000 ppm TEG in diet. Short-term repeated aerosol exposure studies in the rat demonstrated that, by nose-only exposure, the threshold for effects by respiratory tract exposure was 1036 mg/cu m. Neither high dosage acute nor repeated exposures to TEG produce hepatorenal injury characteristic of that caused by the lower glycol homologues. Elimination studies with acute peroral doses of TEG given to rats and rabbits showed high recoveries (91-98% over 5 days), with the major fraction appearing in urine (84-94%) and only 1% as carbon dioxide. TEG in urine is present in unchanged and oxidized forms, but only negligible amounts as oxalic acid. Developmental toxicity studies with undiluted TEG given by gavage produced maternal toxicity in rats (body weight, food consumption, water consumption, and relative kidney weight) with a NOEL of 1126 mg/kg/day, and mice (relative kidney weight) with a NOEL of 5630 mg/kg/day. Developmental toxicity, expressed as fetotoxicity, had a NOEL of 5630 mg/kg/day with the rat and 563 mg/kg/day with mice. Neither species showed any evidence of embryotoxicity or teratogenicity. There was no evidence for reproductive toxicity with mice given up to 3% TEG in drinking water in a continuous breeding study. TEG did not produce mutagenic or clastogenic effects in the following in vitro genetic toxicology studies: Salmonella typhimurium reverse mutation test, SOS-chromotest in E. coli, CHO forward gene mutation test (HGPRT locus), CHO sister chromatid exchange test, and a chromosome aberration test with CHO cells. The use patterns suggest that exposure to TEG is mainly occupational, with limited exposures by consumers. Exposure is normally by skin and eye contact. Local and systemic adverse health effects by cutaneous exposure are likely not to occur, and eye contact will produce transient irritation without corneal injury. The very low vapor pressure of TEG makes it unlikely that significant vapor exposure will occur. Aerosol exposure is not a usual exposure mode, and acute aerosol exposures are unlikely to be harmful, although a peripheral sensory irritant effect may develop. However, repeated exposures to a TEG aerosol may result in respiratory tract irritation, with cough, shortness of breath and tightness of the chest. Recommended protective and precautionary measures include protective gloves, goggles or safety glasses and mechanical room ventilation. LC(50) data to various fish, aquatic invertebrates and algae, indicate that TEG is essentially nontoxic to aquatic organisms. Also, sustained exposure studies have demonstrated that TEG is of a low order of chronic aquatic toxicity. The bioconcentration potential, environmental hydrolysis, and photolysis rates are low, and soil mobility high. In the atmosphere TEG is degraded by reacting with photochemically produced hydroxyl radicals. These considerations indicate that the potential for ecotoxicological effects with TEG is low. |
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| Soil Adsorption/Mobility | Using a structure estimation method based on molecular connectivity indices(1), the Koc of triethylene glycol can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that triethylene glycol is expected to have very high mobility in soil(SRC). |
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| TSCA Test Submissions | Acute dermal toxicity was evaluated in groups of female Hilltop-Wistar albino rats administered unreported doses of triethylene glycol. The dermal LD50 is reported to be >16.0 mL/kg. Specific mortalities, clinical signs of toxicity, and gross pathology are not reported. The document provides only a brief summary of this acute toxicity study, so no further methods or observations are reported.Triethylene glycol (112-27-6) was evaluated for acute inhalation toxicity in one group of 5 male and 5 female Sprague-Dawley albino rats exposed to the test material for four hours at at concentration of 5.2 mg/L. The use of controls was not specified. The animals were observed for 14-days post-exposure. No animals died during the study. Clinical signs on the day of exposure included periocular wetness, blepharospasm, wet (oily) fur, and an absence of toe and tail pinch reflexes. Unkempt fur was the only clinical sign observed during the post-exposure period. Necropsy revealed no macroscopic lesions in animals sacrificed at the end of the 14-day observation period. Histopathological examination was not specified. The 4-hour LC50 for triethylene glycol in Sprague-Dawley rats was greater than 5.2 mg/L.The metabolism of triethylene glycol was evaluated in groups of rats (number and sex not reported) orally administered (gavage or diet not specified) 1.2 g/kg. The proportion of the dose that was excreted in the urine unchanged was 59% and 3.8% at days 1 and 2 post-dosing, respectively. The procedure for recovery of triethylene glycol from the urine was not reported. No metabolites of the test compound were identified.A perinatal/postnatal teratology study was conducted with 50 pregnant Specific Pathogen Free CD-1 albino mice administered triethylene glycol by oral gavage at a dose level of 11270 mg/kg/day (the maximum tolerated dose calculated from a previous study) on gestation days 7-14. Mortality was not observed and no pharmacotoxic signs were observed except for a roughened haircoat in 1 animal. Statistical analysis were determined by the Student's t-test (p<0.05). The mean maternal body weights and the mean weight change (Day 18-7) were significantly lower than control values. Mean pup counts and offspring viability were similiar to controls. Although mean pup weights were significantly lower than the control weights at birth, mean pup weights at day 3 were comparable to controls. No apparent adverse effects on reproductive or neonatal outcome were observed. Gross necropsy observations were not reported.For more TSCA Test Submissions (Complete) data for TRIETHYLENE GLYCOL (6 total), please visit the HSDB record page. |
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| Atmospheric Concentrations | RURAL/REMOTE: Triethylene glycol was found in 5 of 25 aerosol samples taken from a light house site in northeastern Puerto Rico, and was identified in a sample taken 30 miles off the south coast(1). |
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| Human Toxicity Excerpts | /SIGNS AND SYMPTOMS/ Splash contamination in man ... causes acute smarting, & this may be followed by transitory disturbance of corneal epithelium with gradually diminishing sensation & signs of irritation, but no persistent injury is to be expected./HUMAN EXPOSURE STUDIES/ ...Evaluated 20% triethylene glycol in petrolatum in human volunteersand the chemical was not a sensitizer./HUMAN EXPOSURE STUDIES/ 20% triethylene glycol in petrolatum was described as not irritating in a patch test evaluated at 48 hr./CASE REPORTS/ A 23-yr-old woman was brought to an emergency room after intentionally ingesting one gulp (volume unspecified) of ... brake fluid. ...The patient was given milk to drink by her family and subsequently vomited. Upon arrival to the emergency room, she was unconscious and had metabolic acidoses (pH 7.03, PCO2 44 mmHg, bicarbonate 11 mmol/L, anion gap 30 mmol/L, serum creatinine 90 umol/L). She was intubated and given 100 mmol of iv sodium bicarbonate. Triethylene glycol is thought to be metabolized by alcohol dehydrogenase to acidic products resulting in metabolic acidosis. To act as a competitor of the alcohol dehydrogenase enzyme, ethanol was administered to maintain a serum ethanol level of 100 mg/dL. The blood pH returned to normal over the next 8 hrs, and ethanol infusion was continued for 22 hr. At 36 hr post ingestion, the patient was discharged to a psychiatric ward. Analysis of blood drawn upon admission did not detect the presence of ethanol, ethylene glycol, methanol... . The above case study described the... brake fluid as 99.9% triethylene glycol. The material safety data sheet for /this brand of/ brake fluid, however, lists its ingredients as 30-60% polyglycol ethers30-60% borate of triethylene glycol monomethyl ether30-60% polyglycol0-10% corrosion inhibitorand 0-10% dye.For more Human Toxicity Excerpts (Complete) data for TRIETHYLENE GLYCOL (6 total), please visit the HSDB record page. |
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| Artificial Pollution Sources | Triethylene glycol's production and use as a solvent, plasticizer in vinyl, polyester and polyurethane resins, as a humectant in printing inks, in the dehydration of natural gas(1) and as a fragrance ingredient in cosmetics(2) may result in its release to the environment through various waste streamsit's use as a bacteriostat and as an inert ingredient to facilitate delivery of formulated pesticide products(3) will result in its direct release to the environment(SRC). |
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| Environmental Biodegradation | AEROBIC: Aerobic river die-away tests, utilizing several different sources of freshwater, have demonstrated that triethylene glycol should biodegrade rapidly in the environment(1). At 20 °C, the degradation of 10 mg/L triethylene glycol was complete within 7-11 days(1). 25 to 92% of the theoretical BOD was reached within 4 weeks incubation during the MITI test using a sludge inoculumthese results were on an upward trend by the end of the test(2) indicating that acclimation may be important for this compound(SRC). Triethylene glycol degraded 85% of theoretical BOD (1.6 gm/gm) after 20 days at 20 °C(3). |
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| Environmental Bioconcentration | An estimated BCF of 3 was calculated in fish for triethylene glycol(SRC), using an estimated log Kow of -1.75(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). |
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| Volatilization from Water/Soil | The Henry's Law constant for triethylene glycol is estimated as 3.2X10-11 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that triethylene glycol is expected to be essentially nonvolatile from water surfaces(2). Triethylene glycol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.32X10-3 mm Hg(3). |
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| Luftstandards | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Triethylene glycol is produced, as an intermediate or final product, by process units covered under this subpart. |
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| Toxizität | LD50 orl-rat: 17 g/kg JIHTAB 28,40,46 |
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