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Schwefelsaeurediamid
SULFURIC DIAMIDE · SULPHAMIDE · SulfaMid · famide · NSC 252 · SULFAMIDE · Suleamide · [S(NH2)2O2]
Identifikatoren & physikalische Daten
| CAS No. | 7803-58-9 |
|---|---|
| Summenformel | H4N2O2S |
| Durchschnittliche Molmasse | 96,11 g/mol |
| Monoisotopische Masse | 95,99934837 g/mol |
| SMILES | NS(N)(=O)=O |
| InChIKey | NVBFHJWHLNUMCV-UHFFFAOYSA-N |
| PubChem CID | 82267 |
| ChEMBL | CHEMBL355001 |
| ChEBI | CHEBI:29368 |
| EC No. | 232-262-9 |
| DTXSID | DTXSID5064885 |
| Lokaler Name | Schwefelsaeurediamid |
Chemische & physikalische Eigenschaften
| XLogP | -1,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 94,6 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 5 |
| Formalladung | 0 |
| Komplexität | 85,3 |
| Schmelzpunkt | 90-92 °C(lit.) |
| Dichte | 1.611 g/mL at 25 °C(lit.) |
| Lagerbedingungen | Inert atmosphere,Room Temperature |
| Löslichkeit | water: soluble50mg/mL, clear, colorless to faintly yellow |
| Aggregatzustand | Crystalline Powder, Free From Visible Impurities |
| pKa (Säurekonstante) | 10.87±0.60(Predicted) |
| Farbe | White to practically white , free from visible impurities |
| pH | 5.67 at 21.7℃ and 10g/L |
| Merck | 14,8922 |
| InChI | 1S/H4N2O2S/c1-5(2,3)4/h(H4,1,2,3,4) |
| InChIKey | NVBFHJWHLNUMCV-UHFFFAOYSA-N |
| SMILES | NS(N)(=O)=O |
| CAS Datenbank | 7803-58-9(CAS DataBase Reference) |
| NIST chemische Informationen | Sulfamide(7803-58-9) |
| EPA chemische Informationen | Sulfamide (7803-58-9) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 3.7% (2 of 54) of reports.WarningH315 (96.3%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 54 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: SulfamideStatus: Active Update: 15-11-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/18217 |
| Hazard Classes and Categories | Skin Irrit. 2 (96.3%) |
| F | 9 |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 28530090 |
| R-Sätze (R) | 36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36-37/39 |
| Gefahrenklasse | IRRITANTEye Irrit. 2Skin Irrit. 2STOT SE 3 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Verwenden
Sulfamide and its derivatives can also be used to prepare fused thiadiazine systems, Reaction with 2-aminoacetophenones affords IH-2,1,3-benzothia- diazine 2,2-dioxides 77 (65JOC3960). The corresponding 3,4-dihydro deriv- atives are readily available from 2-aminobenzylamines with either sulfuryl chloride (70M1443) or sulfamide (66USP3278532; 71MI055). These kinds of compounds can also be obtained from N-aryl-N'-alkylsulfamides and s-trioxane in a reaction involving cyclization by intramolecular sulfamido- methylation (79JOC2032) (Scheme 30).