5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid

IMIPRAMINE HCL · g22355 · imidol · ia-pram · imavate · iprogen · tofranil · deprinol

Identifikatoren & physikalische Daten

CAS No.	113-52-0
Summenformel	C19H25ClN2
Durchschnittliche Molmasse	316,9 g/mol
Monoisotopische Masse	316,1706265 g/mol
SMILES	CN(C)CCCN1c2ccccc2CCc2ccccc21.Cl
InChIKey	XZZXIYZZBJDEEP-UHFFFAOYSA-N
PubChem CID	8228
ChEMBL	CHEMBL1692
EC No.	204-030-7
DTXSID	DTXSID7040738
Lokaler Name	5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)	6,5
H-Brücken-Donoren	1
H-Brücken-Akzeptoren	2
Frei drehbare Bindungen	4
Schwere Atome	22
Formalladung	0
Komplexität	291
Löslichkeit	>47.5 [ug/mL] (The mean of the results at pH 7.4)H2O: 50 mg/mLSoluble in water
Collision Cross Section	165.1 Å² [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
Schmelzpunkt	168-1700C
Flammpunkt	9℃
Lagerbedingungen	2-8°C
Aggregatzustand	crystalline
Farbe	white
pH	4.2~5.2(100g/l,25℃)
Merck	14,4920
InChI	1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
InChIKey	XZZXIYZZBJDEEP-UHFFFAOYSA-N
SMILES	Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
CAS Datenbank	113-52-0(CAS DataBase Reference)
EPA chemische Informationen	5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride (113-52-0)

Sicherheit & Vorschriften

GHS-Einstufung	WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 92 reports by companies from 4 notifications to the ECHA C&L Inventory.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Regulatorische Informationen	Imipramine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Weitere Sicherheitsinformationen	IMAP assessments - 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride: Human health tier I assessmentIMAP assessments - 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride: Environment tier I assessment
Hazard Classes and Categories	Acute Tox. 4 (100%)
Treatment	Obtain an ECG and immediately initiate cardiac monitoring. Protect the patient's airway, establish an intravenous line and initiate gastric decontamination. A minimum of 6 hours of observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is necessary. If signs of toxicity occur at anytime during this period, extended monitoring is required. (L1712)
Expositionspfade	Rapidly and well absorbed after oral administration. Bioavailability is approximately 43%. Peak plasma concentrations usually attained 1 - 2 hours following oral administration. Absorption is unaffected by food.
Toxizitätsübersicht	Imipramine works by inhibiting the neuronal reuptake of the neurotransmitters norepinephrine and serotonin. It binds the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter preventing or reducing the reuptake of norepinephrine and serotonin by nerve cells. Depression has been linked to a lack of stimulation of the post-synaptic neuron by norepinephrine and serotonin. Slowing the reuptake of these neurotransmitters increases their concentration in the synaptic cleft, which is thought to contribute to relieving symptoms of depression. In addition to acutely inhibiting neurotransmitter re-uptake, imipramine causes down-regulation of cerebral cortical beta-adrenergic receptors and sensitization of post-synaptic serotonergic receptors with chronic use. This leads to enhanced serotonergic transmission.

Anwendungen & Verwendung

Verwenden

Imipramine hydrochloride is used as a serotonin uptake inhibitor. It mainly used in the treatment of major depression and enuresis (inability to control urination). It has also been evaluated for use in panic disorder.