HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Paramethadione
Paramethadione · a348 · A 348 · Paradione · HSDB 3245 · BRN 0127715 · Isethadionum · Isoethadione
Identifikatoren & physikalische Daten
| CAS No. | 115-67-3 |
|---|---|
| Summenformel | C7H11NO3 |
| Durchschnittliche Molmasse | 157,17 g/mol |
| Monoisotopische Masse | 157,07389321 g/mol |
| SMILES | CCC1(C)OC(=O)N(C)C1=O |
| InChIKey | VQASKUSHBVDKGU-UHFFFAOYSA-N |
| PubChem CID | 8280 |
| ChEMBL | CHEMBL1100 |
| ChEBI | CHEBI:7921 |
| EC No. | 204-098-8 |
| DTXSID | DTXSID8023420 |
Chemische & physikalische Eigenschaften
| XLogP | 0,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 46,6 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 11 |
| Formalladung | 0 |
| Komplexität | 214 |
| Arzneimittel | Pharmaceuticals -> Antiepileptics |
| pH | ABOUT 6 (1 IN 40 SOLN) |
| LogP (Verteilungskoeffizient) | 0.3 |
| Geruch | FRUITY, ESTERLIKE ODOR |
| Dichte | 1.118-1.1240 @ 25 °C/4 DEGd425 1.1180-1.1240 |
| Color/Form | CLEAR, COLORLESS LIQUID |
| Löslichkeit | SLIGHTLY SOL IN WATERFREELY SOL IN ALCOHOL, BENZENE, CHLOROFORM, ETHER1.35e+02 g/L |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Siedepunkt | 101 to 102 °C at 11.3 mm Hg101.5 °C281.82°C (rough estimate) |
| Decomposition | When heated to decomposition it emits toxic fumes of /nitrogen oxides/. |
| Schmelzpunkt | 31-32 °C |
| Brechungsindex | INDEX OF REFRACTION: 1.449 @ 25 °C/DnD25 1.449 |
| pKa (Säurekonstante) | -2.18±0.40(Predicted) |
| EPA chemische Informationen | Paramethadione (115-67-3) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Regulatorische Informationen | Hazard Traits - Developmental Toxicity |
| FDA-Anforderungen | Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended21 U.S.C. 321-392). |
| Special Reports | Graca LM, Machado MHActa Med Port 8 (7-8): 441-9 (1995). Teratogenic effects of exogenous agents.Brent RL, Beckman DAClin Obstet Gynecol 37 (3): 646-70 (1994). The contribution of environmental teratogens to embryonic and fetal loss.Stevenson REHuman Malformations and Related Anomalies (Oxford Monographs on Medical Genetics 27: 137-68 (1993). The environmental basis of human anomalies.Schardein JLChemically Induced Birth Defects 2: 157-207 (1993). /A review of the/ anticonvulsants.For more Special Reports (Complete) data for PARAMETHADIONE (7 total), please visit the HSDB record page. |
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| Lagerbedingungen | Store below 40 °C (104 °F), preferably between 15 and 25 °C (59 and 77 °F), unless otherwise specified by manufacturer. Store in a tight container. /Paramethadione Capsules/ |
| Wechselwirkungen | Concurrent use of alcohol or CNS depression-producing medications with dione anticonvulsants may enhance CNS depression. /Dione anticonvulsants/Concurrent use of tricyclic antidepressantshaloperidolloxapinemaprotiline |
Anwendungen & Verwendung
Verwenden
Paramethadione is also used in minor forms of epilepsy.