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Bromomethyl methyl ether
MOMBr · Bromo(methoxy)methane · BromomethyL · Methane, bromomethoxy- · bromomethoxy-methan · Methoxybromomethane · METHOXYMETHYL BROMIDE · BROMOMETHYL METHYL ETHER
Identifikatoren & physikalische Daten
| CAS No. | 13057-17-5 |
|---|---|
| Summenformel | C2H5BrO |
| Durchschnittliche Molmasse | 124,96 g/mol |
| Monoisotopische Masse | 123,95237688 g/mol |
| SMILES | COCBr |
| InChIKey | JAMFGQBENKSWOF-UHFFFAOYSA-N |
| PubChem CID | 83093 |
| EC No. | 670-774-8 |
| DTXSID | DTXSID6065341 |
Chemische & physikalische Eigenschaften
| XLogP | 0,9 |
|---|---|
| Polarare Oberfläche (TPSA) | 9,2 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 4 |
| Formalladung | 0 |
| Komplexität | 10 |
| Stoffklassen | Other Classes -> Halogenated Ethers |
| SpringerMaterials Properties | Molecular structure |
| Physical Description | Colorless liquid with a pungent odor[Alfa Aesar MSDS] |
| Siedepunkt | 87 °C (lit.) |
| Dichte | 1.531 g/mL at 25 °C (lit.) |
| Brechungsindex | n20/D 1.456(lit.) |
| Flammpunkt | 80 °F |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | Chloroform (Soluble), Methanol (Slightly)Sparingly soluble in water. |
| Aggregatzustand | clear liquid |
| Wichte | 1.531 |
| Farbe | Colorless to Light yellow to Light orange |
| BRN | 1730853 |
| InChI | 1S/C2H5BrO/c1-4-2-3/h2H2,1H3 |
| InChIKey | JAMFGQBENKSWOF-UHFFFAOYSA-N |
| SMILES | COCBr |
| CAS Datenbank | 13057-17-5(CAS DataBase Reference) |
| NIST chemische Informationen | Bromomethyl methyl ether(13057-17-5) |
| EPA chemische Informationen | Methane, bromomethoxy- (13057-17-5) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH226 (100%): Flammable liquid and vapor [Warning Flammable liquids]P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 54 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Methane, bromomethoxy-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| Gefahrenübersicht | An irritant and lachrymatorHarmful by ingestion and skin absorptionToxic by inhalationSuspected carcinogen[Alfa Aesar MSDS] See Chloromethyl methyl ether. |
| Hazard Classes and Categories | Flam. Liq. 3 (100%) |
| Unerwünschte Wirkungen | Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears. |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 1992 3/PG 3 |
| Zollcode | 29091990 |
| R-Sätze (R) | 10-20/21/22-36/37/38-40 |
| Gefahrensymbole | Xn |
| Sicherheitshinweise (S) | 26-36/37 |
| Gefahrenklasse | 6.1Acute Tox. 4 DermalCarc. 2Eye Irrit. 2Flam. Liq. 3Skin Irrit. 2STOT SE 3 |
| Verpackungsgruppe | II |
| Lagerklasse | 3 - Flammable liquids |
Anwendungen & Verwendung
Verwenden
Bromomethyl methyl ether is used as reagent for protection of OH groups as their methoxymethyl (MOM) ethers. It is used in enantiocontrolled synthesis of intermediate containing carbons 18 to 35 of the macrocyclic immunosuppressant FK-506. It was used in the synthesis of 1-methoxymethyl-4-tritylthio-2-azetidinone.