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di-N-Octyl Phthalate
DOP · Dioctyl phthalate · Dnop · DI-N-OCTYL PHTHALATE · Octyl phthalate · DICAPRYL PHTHALATE · di-n-octyl · di-1-octylphthalate
Identifikatoren & physikalische Daten
| CAS No. | 117-84-0 |
|---|---|
| Summenformel | C24H38O4 |
| Durchschnittliche Molmasse | 390,6 g/mol |
| Monoisotopische Masse | 390,2770097 g/mol |
| SMILES | CCCCCCCCOC(=O)c1ccccc1C(=O)OCCCCCCCC |
| InChIKey | MQIUGAXCHLFZKX-UHFFFAOYSA-N |
| PubChem CID | 8346 |
| ChEMBL | CHEMBL1409747 |
| ChEBI | CHEBI:34679 |
| EC No. | 204-214-7 |
| DTXSID | DTXSID1021956 |
Chemische & physikalische Eigenschaften
| XLogP | 9,1 |
|---|---|
| Polarare Oberfläche (TPSA) | 52,6 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 18 |
| Schwere Atome | 28 |
| Formalladung | 0 |
| Komplexität | 369 |
| Stoffklassen | PhthalateSemi-Volatile Organic Compound (SVOC) |
| Polymers | Plastics & Rubber -> Phthalate Esters |
| LogP (Verteilungskoeffizient) | log Kow = 8.105.22 |
| Dichte | 0.98 at 77 °F (USCG, 1999) - Less dense than waterwill floatSpecific gravity: 0.978 at 20 °C.978 @ 20°C0.980 g/mL at 20 °C(lit.) |
| Viscosity | 39 mPa.s at 20 °C |
| Color/Form | Clear, oily liquidLiquid at room temperature |
| Löslichkeit | less than 1 mg/mL at 66 °F (NTP, 1992)In water, 0.022 mg/L at 25 °CChloroform (Slightly), Methanol (Slightly)Insoluble in water. |
| Flammpunkt | 219 °F (NTP, 1992)420 °F (215 °C) (Open cup)219 °C |
| Endocrine Disruptors | Potential endocrine disrupting compound |
| Siedepunkt | 428 °F at 760 mmHg (NTP, 1992)BP: 220 °C at 2 mm Hg380 °C |
| Decomposition | When heated to decomp it emits acrid smoke and irritating fumes. |
| Schmelzpunkt | -13 °F (NTP, 1992)25 °C-25℃ |
| Dampfdruck | 5(x 10-8 mmHg) at 82 °C, 500 at 132 °C (Gross and Colony, 1973) |
| Brechungsindex | n20/D 1.485 |
| Lagerbedingungen | 2-8°C |
| Aggregatzustand | Oily Liquid |
| Farbe | Colourless |
| Wichte | 0.98 |
| Merck | 14,2864 |
| BRN | 1915994 |
| Henry-Konstante | 1.41(x 10-12 atmm3/mol) at 25 °C (approximate - calculated from water solubility and vapor pressure) |
| Dielektrizitätskonstante | 5.1(24℃) |
| Hauptanwendungen | cleaning productscosmeticsfood and beveragespersonal care |
| InChI | 1S/C24H38O4/c1-3-5-7-9-11-15-19-27-23(25)21-17-13-14-18-22(21)24(26)28-20-16-12-10-8-6-4-2/h13-14,17-18H,3-12,15-16,19-20H2,1-2H3 |
| InChIKey | MQIUGAXCHLFZKX-UHFFFAOYSA-N |
| SMILES | CCCCCCCCOC(=O)c1ccccc1C(=O)OCCCCCCCC |
| CAS Datenbank | 117-84-0(CAS DataBase Reference) |
| NIST chemische Informationen | Di-n-octyl phthalate(117-84-0) |
| EPA chemische Informationen | Di-n-octyl phthalate (117-84-0) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 57.1% (36 of 63) of all reports.WarningH361 (41.3%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]P203, P280, P318, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 63 reports by companies from 7 notifications to the ECHA C&L Inventory.Not Classified |
|---|---|
| Regulatorische Informationen | Chemical: 1,2-Benzenedicarboxylic acid, 1,2-dioctyl esterHazard Traits - Developmental ToxicityEndocrine ToxicityImmunotoxicityReproductive ToxicityRespiratory ToxicityRegulation (EC) No 178/2002 (amended)1,2-Benzenedicarboxylic acid, 1,2-dioctyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2-Benzenedicarboxylic acid, 1,2-dioctyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Restricted substance: Di-n-octyl phthalate (DNOP)1,2-Benzenedicarboxylic acid, dioctyl ester: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - Phthalate esters: Environment tier II assessment |
| DOT-Kennzeichnung | Class 9 |
| Brandgefahren | Special Hazards of Combustion Products: None (USCG, 1999) |
| Brandpotenzial | Combustible. |
| Gesundheitsgefahren | Produces no ill effects at normal temperatures but may give off irritating vapor at high temperature. (USCG, 1999) |
| Gefahrenübersicht | Di-n-octylphthalate is a colorless, odorless, oily liquid that doesn't evaporate easily. It is a man-made substance used to keep plastics soft or more flexible. This type of plastic can be used for medical tubing and blood storage bags, wire and cables, carpetback coating, floor tile, and adhesives. It is also used in cosmetics and pesticides.There is confusion in the naming of the dioctyl phthalate (DOP) esters: Di-n-octyl phthalate, Di-sec-octyl phthalate, and Diisooctyl phthalate. [CHEMINFO] A mucous membrane irritantLike dioctyl phthalate, it may cause CNS depression and mild liver toxicity after ingestion of large amounts[HSDB] Causes some liver injury in high-dose feeding studies of rats, but no evidence of significant reproductive effects[ATSDR ToxProfiles] An irritant[MSDSonline] See PHTHALATE ESTERS. |
| FDA-Anforderungen | Dioctylphthalate is an indirect food additive for use only as a component of adhesives. |
| Reaktive Gruppe | Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters |
| Special Reports | NTP/CERHRMonograph on the Potential Human Reproductive and Developmental Effects of Di-n-Octyl Phthalate (DnHP), NIH Publication No. 03-4488 (May 2003). DnOP is one of 7 phthalate chemicals evaluated by the NTP CERHR Phthalates Expert Panel. These phthalates were selected for evaluation because of high production volume, extent of human exposures, use in children's products, and/or published evidence of reproductive or developmental toxicity. NTP-CERHR monographs are transmitted to federal and state agencies, interested parties, and the public and are available in electronic PDF format on the CERHR web site and in printed text or CD-ROM from the CERHR.[Available from, as of March 17, 2015: http://ntp.niehs.nih.gov/ntp/ohat/phthalates/dnop/dnop_monograph_final.pdf]HHS/ATSDRToxicological Profile for Di-n-Octylphthalate PB/98/101033/AS (September 1997). The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies.[Available from, as of March 17, 2015: http://www.atsdr.cdc.gov/toxprofiles/index.asp]Nat'l Research Council CanadaEffects of Phthalate Esters in the Canadian Environ (1976) NRCC No.17583USEPAAmbient Water Quality Criteria Doc for: Phthalate Esters (1980) EPA 440/5-80-067For more Special Reports (Complete) data for DI-N-OCTYL PHTHALATE (8 total), please visit the HSDB record page. |
| RCRA-Anforderungen | U107As stipulated in 40 CFR 261.33, when 1,2-benzenedicarboxylic acid, dioctyl ester, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5). |
| TSCA-Anforderungen | Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1,2-Benzenedicarboxylic acid, dioctyl ester is included on this list. Effective date 10/04/82Sunset date 10/04/92. |
| Brandbekämpfung | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Firefighting Hazards | Carbon oxides |
| Brandbekämpfungsverfahren | Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Water or foam may cause frothing.Wear self contained breathing apparatus for fire fighting if necessary. |
| Lagerbedingungen | Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. |
| Reinigungsverfahren | Environmental precautions: Do not let product enter drains./ACCIDENTAL RELEASE MEASURES/ Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal. |
| Freisetung ohne Brand | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: |
| Entsorgungsverfahren | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U107, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.The following wastewater treatment technologies have been investigated for di-n-octyl phthalate: Biological treatment, solvent extraction.A good candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds. A good candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids. A good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids.Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging: Dispose of as unused product. |
| Preventive Measures | Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Normal measures for preventive fire protection.SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of work day.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. |
| Isolation and Evacuation | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: |
| Threshold Limit Values (TLV) | 8 hr Time Weighted Avg (TWA): 5 mg/cu m. |
| Protective Action Criteria (PAC) | 5.0 [mg/m3]1600 [mg/m3]9300 [mg/m3] |
| Toxikologische Informationen | CDC-ATSDR Toxicological Profile |
| Körperbelastung | Di-n-octyl phthalate was detected in human adipose tissue collected throughout the US during the 1982 National Human Adipose Tissue Survey(1). Di-n-octyl phthalate was found in the serum of 1 of 41 young (17-47 months) Puerto Rican girls with premature breast development at a concentration of 438 ug/L(2). The degradation product di-n-octyl phthalate, mono-n-octyl phthalate was detected in the serum of 12 of 501 female and 15 of 502 male seniors from Uppsala, Sweden at a maximum of 5.55 and 10.7 mg/mL, respectively(3). |
| Wechselwirkungen | Male rats, initiated with a single intraperitoneal dose of the carcinogen diethylnitrosamine and then partially hepatectomized, did not experience any liver weight gain after 10 weeks of dietary exposure to 500 mg/kg/day of di-n-octylphthalate ... When exposure was extended to 26 weeks, small increases in absolute liver weight that were not significant (p < 0.05) were observed at di-n-octylphthalate doses of 250 mg/kg/day (2% increase) and 500 mg/kg/day (8% increase). However, when combined with diminished body weight gains, relative liver weight gains were increased by 5-16% when compared with control values.Male Sprague-Dawley rats were subjected to two-thirds partial hepatectomy which was followed 18 hr later by an intraperitoneal injection of diethylnitrosamine (DEN) at a dose of 30 mg/kg. Di(2-ethylhexyl)phthalate (DEHP) was added to the diet at 0.5%. Mono(2-ethylhexyl)phthalate (MEHP) and 2-ethylhexanol (2-EH) were added at equimolar levels with di(2-ethylhexyl)phthalate. Di-n-octyl-phthalate (DOP) was added to 1%. The development of gamma-glutamyl-transpeptidase positive (GGT+) foci was strongly induced by di-n-octyl-phthalate in the livers of rats that had received a subcarcinogenic dose of diethylnitrosamine. None of the other compounds showed any tumor promoting activity. The development of gamma-glutamyl-transpeptidase positive preneoplastic foci in livers of rats was neither enhanced nor suppressed when rats were fed a dose equimolar to 0.5% di(2-ethylhexyl)phthalate. An elevated carnitine acetyltransferase (CAT) level was found following treatment with mono(2-ethylhexyl)phthalate or di(2-ethylhexyl)phthalate. Mono(2-ethylhexyl)phthalate significantly decreased liver gamma-glutamyl-transpeptiase activity. In addition mono(2-ethylhexyl) phthalate lowered the mean number of foci/square centimeter below that of the 2-ethylhexanol treated group. /It was found/ that di-n-octyl-phthalate can act as a tumor promoter, and this activity seems to be unrelated to liver peroxisome proliferation (as measure by carnitine acetyltransferase).An in vivo assay using Salmonella typhimurium TA 98 showed that di-n-octylphthalate enhanced the mutagenicity of two tryptophan pyrolysis products, which is suggestive of increased mutagenic activity in high-temperature cooking if di-n-octylphthalate is present ... . |
| Zielorgane | Hepatic (Liver) |
| Gesundheitliche Auswirkungen | Phthalate esters are endocrine disruptors. Animal studies have shown that they disrupt reproductive development and can cause a number of malformations in affected young, such as reduced anogenital distance (AGD), cryptorchidism, hypospadias, and reduced fertility. The combination of effects associated with phthalates is called 'phthalate syndrome’. (A2883) |
| Ökotoxizitätswerte | LC50Species: Micropterus salmoides (Large mouth bass)Concentration: 32,900 ug/L for 7-8 days /Conditions of bioassay not specified/ /From table/Species: Ictalurus punctatus (Channel catfish)Concentration: 690 ug/L for 7 days /Conditions of bioassay not specified/ /From table/Species: Phasianus colchicus (ring-necked pheasant) age 10 daysoral >5000 ppm for 5 daysSpecies: Eisenia fetida (earthworm) adult, weight 300-500 mgdermal 3140 (2270-4330) ug/sq cm for 48 hrSpecies: Americamysis bahia (Opossum shrimp)Conditions: saltwater, flow through, 24.8 °C, pH 7.9-8.1, salinity 20-22 ppt, dissolved oxygen 6.6-7.0 mg/LConcentration: 125000 ug/L for 28 days /98% purity/ |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), log Koc values of 4.38-6.3(2-3), indicate that di-n-octyl phthalate is expected to be immobile in soil(SRC). Volatilization of di-n-octyl phthalate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.6X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 1.0X10-7 mm Hg(3), and water solubility, 0.022 mg/L(4). However, adsorption to soil is expected to attenuate volatilization(SRC). Di-n-octyl phthalate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Di-n-octyl phthalate, present at 100 mg/L, reached 67% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(5). In a model terrestrial-aquatic ecosystem, di-n-octyl phthalate was rapidly degraded by organisms in the system, having a half-life of 5 days(6). Respirometric measurements of soil amended with di-n-octyl phthalate shows that when acclimated, there is some microbial utilization, although this is marginal at 4 and 10 °C(7).AQUATIC FATE: Based on a classification scheme(1), log Koc values of 4.38-6.3(2-3), indicate that di-n-octyl phthalate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 2.6X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 1.0X10-7 mm Hg(3), and water solubility, 0.022 mg/L(5). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 31 and 230 days, respectively(SRC). Hydrolysis half-lives of 7.7 years and 280 days at pH values of 7 and 8, respectively, were estimated(6). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column(SRC). Volatilization of di-n-octyl phthalate from model waste stabilization ponds was not observed(7). According to a classification scheme(8), BCFs of 1.16-9400 in mosquito fish(9), suggest the potential for bioconcentration in aquatic organisms is low to very high(SRC), this range may indicate the ability of aquatic organisms to readily metabolize this class of compounds(3). Di-n-octyl phthalate was biodegraded 85% after 10 days incubation in Rhine river water at 20 °Cat 4 °C, biodegradation was negligible(10).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), di-n-octyl phthalate, which has a vapor pressure of 1.0X10-7 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase di-n-octyl phthalate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 19 hours(SRC), calculated from its rate constant of 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase di-n-octyl phthalate may be removed from the air by wet and dry deposition(SRC). Di-n-octyl phthalate has a strong UV absorption band at 274.5 nm which extends beyond 290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). |
| Lebensmitteluntersuchungswerte | Di-n-octyl phthalate was detected in one sample of 80 proof vodka at a concentration of 131 ppb and one sample of 100 proof vodka at 57 ppb(1). It was also detected in two samples of flavored 80 proof vodka at 75 and 123 ppb(1). Di-n-octyl phthalate was not detected (detection limit 20 ng/g dry weight) in food samples collected over four days from a university restaurant, Paris, Francefood samples tested were fish terrine, mixed salad, corn salad, radishes, lasagne, roast beef, chicken leg, mixed steak, basmati rice, fried vegetables, fried potatoes, plain yogurt, Gruyere cheese, Camembert cheese, granny apple, black grapes, stewed apples and fruit salad(2). |
| Unerwünschte Wirkungen | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| Expositionspfade | Oral (L1903)inhalation (L1903)dermal (L1903) |
| Milk Concentrations | Di-n-octyl phthalate was detected, not quantified in one sample of dried milk(1). The contamination was believed to be a result of contact with plastic(1). |
| Toxizitätsübersicht | IDENTIFICATION AND USE: Di-n-octylphthalate (DNOP) is a clear, oily liquid. It is used as a plasticizerDNOP can represent 5-60% of the total weight of the plastics and resins. It is found in cosmetics and colorants. DNOP also serves as a carrier for catalysts or initiators and as a substitute for electrical capacitor fluid. HUMAN EXPOSURE AND TOXICITY: In 173 subjects with suspected dermatoses to plastic or glue allergens, two subjects (1.2% of the group) experienced irritation after patch testing with 2.0% DNOP. None of the patients had allergic reactions. There is a case study of a worker with continuous exposure to DNOP during the manufacture of imitation leather, who developed an asthmatic reaction to the substance. Women with endometriosis showed significantly higher concentrations of DNOP in their blood in a study of 49 infertile women with endometriosis (study group), and 38 age-matched women without endometriosis (control group I) but with infertility related to tubal defects, fibroids, polycystic ovaries, idiopathic infertility and pelvic inflammatory diseases diagnosed by laparoscopy and a further group of 21 age-matched women (control group II). An increase in toxic polyneuritis has been reported in workers exposed primarily to dibutyl phthalates. Lesser levels of exposure to dioctyl, diisooctyl, benzylbutyl phthalates, and tricresyl phosphate were also noted. ANIMAL STUDIES: DNOP was reported to be a slight skin irritant when applied to the depilated skin of guinea pigs. However, DNOP was not a skin sensitizer in guinea pigs. Ocular administration of DNOP resulted in slight conjunctival irritation and no corneal damage. The results of several acute- and intermediate-duration oral studies in rodents indicate that the potential of DNOP to cause adverse reproductive and developmental effects is low. Unlike other phthalate esters such as DEHP, DNOP does not appear to affect testicular function or morphology. Observed hepatic effects in intermediate duration studies consisted of a statistically significant increase in hepatic ethoxyresorufin-0-deethylase activity and histological changes in hepatic architecture. Thyroid toxicity was also noted at this concentration. Rats treated with 100, 300, or 600 mg/kg DNOP by ip injection for up to 90 day were evaluated for immunological responses. The high dose resulted in early loss of distinction between the cortex and medulla of the thyroid, reduced numbers of follicles in the lymph nodes, and loss of morphology in the adrenal glands. However, there was no effect on immune response. Results of studies in Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 (with and without S-9 metabolic activation systems) indicated that DNOP is not mutagenic. ECOTOXICITY STUDIES: The toxicity of DNOP was assessed by measuring the effect of exposure to these compounds on the fecundity of Daphnia magna and on the hatching and survival of the early life stages of the fathead minnow Pimephales promelas. For Daphnia magna, exposure to 1.0 mg/L DNOP caused a significant reduction in reproduction. Exposure to DNOP did not affect survival of either early embryos or larvae of the fathead minnow at doses up to 10 mg/L (the highest dose tested). Hatching of the embryos was significantly decreased at 10 mg/L, but not at 3.2 mg/L DNOP.Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expression. Some phthalates have also been shown to reduce the expression of insulin-like peptide 3 (insl3), an important hormone secreted by the Leydig cell necessary for development of the gubernacular ligament. Animal studies have shown that these effects disrupt reproductive development and can cause a number of malformations in affected young. (A2883) |
| CERCLA-Meldepflichtmengen | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| Landesrichtlinien für Trinkwasser | (FL) FLORIDA 140 ug/L |
| Wassergefährdungsklasse (WGK) | 2 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | 2810 |
| Zollcode | 29173200 |
| RTECS-Nr. | TI1925000 |
| R-Sätze (R) | 60-61 |
| Toxizität | Acute oral LD50 for mice 6,513 mg/kg (quoted, RTECS, 1985):rats 13,000 mg/kg (Dogra et al., 1989):mice 1,250-1,954 mg/kg (Etnier, 1987). |
| Sicherheitshinweise (S) | 23-24/25 |
| Lagerklasse | 10 - Combustible liquids |
| Gefahrstoffdaten | 117-84-0(Hazardous Substances Data) |
| Gefahrenklasse | Aquatic Chronic 4 |
Anwendungen & Verwendung
Verwenden
Di-n-octyl phthalate is used as a plasticizer for many resins and elastomers. It acts as an additive. It is also used for medical tubing and blood storage bags, wire and cables, carpet back coating, floor tile and in cosmetics.