N,N-Bis(2-hydroxyethyl)dodecanamid

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

8.1 [mg/m3]

89 [mg/m3]

530 [mg/m3]

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

TERRESTRIAL FATE: When dissolved in aqueous solutions, N,N-di(2-hydroxyethyl)lauramide will have soil mobility ranging from medium to high(3) based on estimated Koc values ranging from 52 to 221(1,2).

AQUATIC FATE: N,N-Di(2-hydroxyethyl)lauramide is essentially nonvolatile from water based upon an estimated Henry's Law constant of 2.16X10-12 atm cu m/mol(1,2,SRC). In natural river water, 98% of N,N-di(2-hydroxyethyl)lauramide was biodegraded in 6 days (20 mg/l)(3). Aquatic bioconcentration and adsorption to sediment are not expected to be important fate processes(SRC).

ATMOSPHERIC FATE: Based on an estimated vapor pressure of approximately 6.7X10-9 mm Hg at 25 °C(1), N,N-di(2- hydroxyethyl)lauramide will exist primarily in the particulate phase in the ambient atmosphere(2). In the vapor phase, it will degrade in the ambient atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 8 hrs(3). Physical removal of particulate N,N-di(2- hydroxyethyl)lauramide from air is likely to occur through wet and dry deposition(SRC).

The CIR Expert Panel concluded that the following 33 diethanolamides are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating and when the levels of free diethanolamine in the diethanolamides do not exceed the present practices of use and concentration of diethanolamine itself. The Expert Panel cautions that ingredients should not be used in cosmetic products in which N-nitroso compounds can be formed...Lauramide DEA...

Safe for use in cosmetics, with qualifications

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=120-40-1]

Using a structure estimation method based on molecular connectivity indexes, the Koc for N,N-di(2-hydroxyethyl)lauramide can be estimated to be about 52(1). The Koc for N,N-di(2-hydroxyethyl)lauramide can be estimated to be about 221 based on an estimated water solubility of 226 mg/L(2) and a regression derived equation(2). According to a suggested classification scheme(3), these estimated Koc values suggest that N,N-di(2-hydroxyethyl)lauramide soil mobility is medium to high(SRC).

N,N-Di(2-hydroxyethyl)lauramide degraded 98% in 6 days in natural river water (20 mg/l)(1). Using four different test methods, N,N-di(2-hydroxyethyl)lauramide degraded 90% (5 mg/l and 19 days), 92% (30 mg/l and 8 days), 93% (10 mg/l and 21 days), and 95% (20 mg/l and 23 hrs), respectively(1).

Lauric Acid Diethanolamine Condensate

TR-480: Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CASRN 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies) (1999 )

12/10/97

No Evidence

No Evidence

No Evidence

Based upon an estimated water solubility of 226 mg/l(1), the BCF of N,N-di(2-hydroxyethyl)lauramide can be estimated to be approximately 29 from a regression-derived equation(1). Based on this BCF value, bioconcentration is not expected to be an important fate process(SRC).

The Henry's Law constant for N,N-di(2- hydroxyethyl)lauramide can be estimated to be 2.16X10-12 atm-cu m/mole using a structure estimation method(1). This value of Henry's Law constant indicates that N,N-di(2- hydroxyethyl)lauramide is essentially nonvolatile from water(2).

LAURIC ACID DIETHANOLAMIDE AT 5 PPM CAUSED 50% INHIBITION OF SEA URCHIN EGG FERTILITY & ALSO CAUSED SHEEP ERYTHROCYTE HEMOLYSIS. APPROX 50% HEMOLYSIS WAS OBSERVED WHEN ERYTHROCYTES WERE TREATED WITH 200 PPM.

DIETARY LEVELS OF LDE AT 0.1, 0.5 & 2.0 FOR 90 DAYS DID NOT EVOKE ANY ADVERSE APPEARANCE OR CONDITION OF RATS. TERMINAL HEMATOLOGICAL EXAMINATION SHOWED REDUCTION IN HEMOGLOBIN LEVEL, HEMATOCRIT & RED CELL COUNT AT 1 & 2 LEVELS IN FEMALES BUT LESS PRONOUNCED IN MALES. SERUM LEVELS OF GLUTAMIC-OXALACETIC TRANSAMINASE WERE ELEVATED AT 0.5 & ABOVE IN FEMALES BUT ONLY AT 0.5 IN MALES. RELATIVE KIDNEY WT WAS INCR IN ALL TEST GROUPS EXCEPT AT 0.1 IN FEMALES & AT 0.1 & 0.5 IN MALES. RELATIVE LIVER WT INCR IN FEMALES AT 2 HIGHEST LEVELS. NO-EFFECT LEVEL WAS 0.1, AN EQUIVALENT OF 50 MG/KG/DAY FOR 90 DAYS.

NONMUTAGENIC IN SALMONELLA TYPHIMURIUM STRAINS TA100 & TA98 WHEN STUDIED BY AMES TEST AT 10, 50, 100, 200 & 1000 UG/PLATE; ALSO NONCARCINOGENIC (NO CELLS TRANSFORMED) WHEN ADMIN AT 0.1, 0.5, 1, 5 & 10 UG/ML TO CELL CULTURE 7708 PREPARED FROM PREGNANT SYRIAN GOLDEN HAMSTERS WHICH WERE KILLED ON DAY 13 & 14 OF GESTATION.

... CONCLUSIONS: Under the conditions of these 2 yr dermal studies, there was no evidence of carcinogenic activity of lauric acid diethanolamine condensate in male or female F344/N rats admin 50 or 100 mg/kg or in male B6C3F1 mice admin 100 or 200 mg/kg. There was some evidence of carcinogenicity in female B6C3F1 mice based on incr incidences of hepatocellular neoplasms. ...

The rate constant for the vapor-phase reaction of N,N-di(2- hydroxyethyl)lauramide with photochemically produced hydroxyl radicals has been estimated to be approximately 48.1X10-12 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of about 8 hours at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1,SRC).