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HCID 8449Erstellt: 26. Oktober 2026

2,4-Dichlorophenol

https://huagongshe.com/de/chemical/8449

Molekülstruktur von 2,4-Dichlorophenol

Identifikatoren & physikalische Daten

CAS No.120-83-2
SummenformelC6H4Cl2O
Durchschnittliche Molmasse163 g/mol
Monoisotopische Masse161,96392011 g/mol
SMILESOc1ccc(Cl)cc1Cl
InChIKeyHFZWRUODUSTPEG-UHFFFAOYSA-N
PubChem CID8449
ChEMBLCHEMBL1143
ChEBICHEBI:16738
EC No.204-429-6
DTXSIDDTXSID1020439

Chemische & physikalische Eigenschaften

XLogP3,1
Polarare Oberfläche (TPSA)20,2
H-Brücken-Donoren1
H-Brücken-Akzeptoren1
Frei drehbare Bindungen0
Schwere Atome9
Formalladung0
Komplexität97,1
StoffklassenOther Classes -> ChlorophenolsCarcinogensChlorinated/Brominated phenolSemi-Volatile Organic Compound (SVOC)
SpringerMaterials Properties13C nuclear magnetic resonance spectrum
PestizidePesticide -> EPA IRISEnvironmental transformation -> Pesticide transformation products (metabolite, successor)
LogP (Verteilungskoeffizient)log Kow = 3.063.173.12
GeruchStrong medicinal
Dichte1.4 at 59 °F (USCG, 1999) - Denser than waterwill sink1.4 g/cm³Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.001.382
Color/FormCOLORLESS CRYSTALS OR NEEDLESHexagonal needles from benzeneWhite ... solidPale yellow solid
Löslichkeitless than 0.1 mg/mL at 64 °F (NTP, 1992)Soluble in carbon tetrachlorideSoluble in ethanol, benzene, chloroform and ethyl ether.Soluble in aqueous alkali, oxygenated and chlorinated solvents.In water, 4.50X10+3 mg/L at 20 °C4.5 mg/mL at 20 °CSlightly soluble
Flammpunkt237 °F (NTP, 1992)113 °C200 °F (open cup)237 °F (closed cup)237 °F (114 °C) (open cup)113 °C o.c.104°C
Endocrine DisruptorsPotential endocrine disrupting compound
Siedepunkt410 °F at 760 mmHg (NTP, 1992)210 °C210.0 °C210 °C @760 [mm Hg]209-210 °C
DecompositionWhen heated to decomposition ... it emits highly toxic fumes of /hydrogen chloride/.
Schmelzpunkt37 °C
Dampfdichte5.6 (vs air)
Dampfdruck0.12 mm Hg at 20 °C
AggregatzustandSolid
FarbeWhite crystal
GeruchPhenolic odour

Sicherheit & Vorschriften

GHS-EinstufungDangerH302: Harmful if swallowed [Warning Acute toxicity, oral]P260, P262, P264, P270, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P361+P364, P363, P391, P405, and P501 (click each P-code to see the statement)H300 (13.7%): Fatal if swallowed [Danger Acute toxicity, oral]P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P361+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Regulatorische InformationenChemical: Phenol, 2,4-dichloro-Hazard Traits - Developmental ToxicityImmunotoxicityReproductive ToxicityCommission Regulation No 844/2012Phenol, 2,4-dichloro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phenol, 2,4-dichloro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)T - indicates a substance that is the subject of a final TSCA section 4 test rule.Status: Active Update: 24-04-2012 https://echa.europa.eu/registration-dossier/-/registered-dossier/2179
Weitere SicherheitsinformationenEvaluation - Phenol, 2,4-dichloro-
DOT-KennzeichnungPoison
BrandgefahrenSpecial Hazards of Combustion Products: Toxic gases can be evolved.Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.
BrandpotenzialCombustible when exposed to heat or flame.Behavior in fire: Solid melts and burns.May accumulate static electrical charges, and may cause ignition of its vapors.
GesundheitsgefahrenTremors, convulsions, shortness of breath, inhibition of respiratory system. (USCG, 1999)
GefahrenübersichtA corrosive substance that can cause injury to the skin, eyes, and respiratory tractExposure to small amounts of the molten or liquid form of the substance may result in extensive skin absorption and rapid death. [ICSC] A corrosive substance that can cause injury to the skin, eyes, and respiratory tractInhalation may cause chemical pneumonitisMay be absorbed through skinEffects in high-dose animal studies include acute tubular necrosis and convulsions[MSDSonline] The mechanism of toxicity is uncoupling oxidative phosphorylationLethal dose is approximately 21 grams or a skin splash of 15 ml of molten 2,4-DCP[AIHA] See CHLOROPHENOLS.
Reaktive GruppePhenols and Cresols
EG-EinstufungSymbol: T, NR: 22-24-34-51/53S: (1/2)-26-36/37/39-45-61
UN-EinstufungUN Hazard Class: 6.1UN Pack Group: III
Special ReportsUSEPAKOZAK VP ET ALREVIEWS OF THE ENVIRONMENTAL EFFECTS OF POLLUTANTS: XI. CHLOROPHENOLS519 PAGES (1979) EPA-600/1-79-012. THIS PAPER DISCUSSES THE HEALTH & ENVIRONMENTAL EFFECTS, PHYSICAL & CHEMICAL PROPERTIES, ANALYTICAL METHODS, BIOLOGICAL ASPECTS (HUMAN & NON-HUMAN), ENVIRONMENTAL DISTRIBUTION & TRANSFORMATION & ENVIRONMENTAL INTERACTIONS OF CHLOROPHENOLS & THEIR CONSEQUENCES. AVAILABLE DATA INDICATE THAT CHLOROPHENOLS DO NOT POSSESS TUMORIGENIC, MUTAGENIC OR TERATOGENIC PROPERTIES. 2,4-DICHLOROPHENOL MAY PROMOTE TUMORS IN MICE. /CHLOROPHENOLS INCLUDING 2,4-DCP/ETHYLBENZENE, PHENOL, 2,4-DICHLOROPHENOL, 2,4,5-TRICHLOROPHENOL, AND PENTACHLOROPHENOL AND THE LIST OF TOXIC POLLUTANTS OF THE CLEAN WATER ACTFED REGIST 46 (5): 2267-73 (1981). DATA ON AQUATIC PERSISTENCE, DEGRADABILITY, & TOXICITY TO FISH, FRESHWATER INVERTEBRATES, MAMMALS AND HUMANS ARE GIVEN SUPPORTING THE RETENTION OF ETHYLBENZENE, PHENOL, 2,4-DICHLOROPHENOL, 2,4,5-TRICHLOROPHENOL & PENTACHLOROPHENOL ON THE TOXIC POLLUTANT LIST OF THE CLEAN WATER ACT.Nat'l Research Council CanadaChlorinated Phenols (1982) NRCC No. 18578Environmental Protection Service. Chlorophenols and Their Impurities in the Canandian Environment Report EPS 3-EC-81-2 (1981)For more Special Reports (Complete) data for 2,4-DICHLOROPHENOL (10 total), please visit the HSDB record page.
RCRA-AnforderungenU081As stipulated in 40 CFR 261.33, when 2,4-dichlorophenol, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).
BrandbekämpfungFire Extinguishing Agents Not to Be Used: Water or foam may cause frothing.Use water spray, foam, powder, carbon dioxide.
Erste-Hilfe-MaßnahmenFresh air, rest. Half-upright position. Refer immediately for medical attention.Wear protective gloves when administering first aid. Remove contaminated clothes. To remove substance use polyethylene glycol 400 or vegetable oil. Rinse skin with plenty of water or shower. Refer immediately for medical attention.Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.
Erste HilfeEYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Sichere LagerungFireproof. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Ventilation along the floor.
Firefighting HazardsFire extinguishing agents: water or foam may be used even though frothing occurs.
BrandbekämpfungsverfahrenAlcohol foam, foam, carbon dioxide, dry chemical.Cool exposed containers with water.Wear goggles, self-contained breathing apparatus, and rubber overclothing (including gown)/when fighting a fire involving 2,4-Dichlorophenol/Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. /Trichlorophenol/
LagerbedingungenSRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants....Store in tightly closed containers in a refrigerator away from oxidizers, acid, acid fumes, acid chlorides, acid anhydrides, caustics...
ReinigungsverfahrenActivated carbon is a good method for removing chlorophenols from water. Competitive adsorption occurs between chlorophenols & humic substances present in nearly all municipal water supplies. This competition decr the capacity of carbon for chlorophenols. /Chlorophenols/Land Spill: Dig a pit, pond, lagoon, or holding area /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner/ to contain liquid or solid material. Cover solids with plastic sheet to prevent dissolving in rain or fire fighting water. /Trichlorophenol/Water Spill: Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom. If dissolved, apply activated carbon at ten times the spilled amount in region of 10 ppm or greater concentration. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Trichlorophenol/
Freisetung ohne BrandSMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
EntsorgungsverfahrenGenerators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U081, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids.The following wastewater treatment technologies have been investigated for 2,4-dichlorophenol: biological treatment, solvent extraction, and resin adsorption.Dissolve in a combustible solvent and incinerate in a furnace equipped with afterburner and scrubber. Recommendable method: Incineration. Not recommendable method: Discharge to sewer. Peer-review: Incinerate at high temp. PCDDs may be formed. (Peer-review conclusions of an IRPTC expert consultation (May 1985))
Verschüttetes entsorgenPersonal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Preventive MeasuresSRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.Keep material out of water sources and sewersBuild dikes to contain flow as necessaryKeep upwindAvoid breathing vapors or dustsWash away any material which may have contacted the body with copious amounts of water or soap and water. /Trichlorophenol/Immediately wash contaminated areas of skin with concentrated soap solution. Contaminated gloves, clothing, shoes should be removed without delay and disposed by incineration.
KörperbelastungThe mean value of 2,4-dichlorophenol in the urine of humans exposed to specific pesticides has been reported to be 203 ug/L(1). The concentration of 2,4-dichlorophenol in the urine of 197 Arkansas children ranged from 7 to 200 ppb(2).
Wechselwirkungen... Topical application of 0.3% dimethylbenzanthracene in benzene as an initiator & 20% (312 mg/kg) 2,4-dichlorophenol for 39 wk promoted papillomas & carcinomas in mice.2,4-Dichlorophenoxyacetic acid (2,4-D) and its metabolite 2,4-dichlorophenol (DCP) are used extensively in agriculture as herbicides, and are suspected of potential endocrine disruptor activity. In a previous study, we showed that these compounds exhibited synergistic androgenic effects by co-treatment with testosterone in the Hershberger assay. To elucidate the mechanisms of the synergistic effects of these compounds on the androgenicity of testosterone, the androgenic action of 2,4-D and DCP was characterized using a mammalian detection system in prostate cancer cell lines. In in vitro assay systems, while 2,4-D or DCP alone did not show androgenic activity, 2,4-D or DCP with 5alpha-dihydroxytestosterone (DHT) exhibited synergistic androgenic activities. Co-treatment of 10 nM 2,4-D or DCP with 10 nM DHT was shown to stimulate the cell proliferation by 1.6-fold, compared to 10 nM DHT alone. In addition, in transient transfection assays, androgen-induced transactivation was also increased to a maximum of 32-fold or 1.28-fold by co-treatment of 2,4-D or DCP with DHT, respectively. However, 2,4-D and DCP exerted no effects on either mRNA or protein levels of AR. In a competitive AR binding assay, 2,4-D and DCP inhibited androgen binding to AR /(androgen receptor)/, up to 50% at concentrations of approximately 0.5 microM for both compounds. The nuclear translocation of green fluorescent protein-AR fusion protein in the presence of DHT was promoted as the result of the addition of 2,4-D and DCP.
ZielorganeImmune
Gesundheitliche AuswirkungenDermally absorbed doses of chlorophenols are potentially more toxic than orally absorbed doses. Within 20 minutes of being accidentally splashed with 2,4-DCP on his right arm and leg, a worker experienced seizures, collapsed, and died shortly thereafter. Lethargy, tremors, convulsions, and/or central nervous system depression have been reported in chlorophenol-exposed animals. (L159)
ÖkotoxizitätswerteToxicity Threshold (Cell Multiplication Inhibition Test) Pseudomonas putida (bacteria) 6 mg/LToxicity Threshold (Cell Multiplication Inhibition Test) Entosiphon sulcatum (protozoa) 0.5 mg/L /Conditions of bioassay not specified/Toxicity Threshold (Cell Multiplication Inhibition Test) Uronema parduczi Chatton-Lwoff (protozoa) 1.6 mg/L /Conditions of bioassay not specified/Toxicity Threshold (Cell Multiplication Inhibition Test) Scenedesmus quadricauda (green algae) 3.6 mg/L /Conditions of bioassay not specified/For more Ecotoxicity Values (Complete) data for 2,4-DICHLOROPHENOL (50 total), please visit the HSDB record page.
UmweltverhaltenTERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 263 in lake sediment, 661 in river sediment and 708 in aquifer material(2) indicate that 2,4-dichlorophenol is expected to have low to moderate mobility in soil(SRC). Volatilization of 2,4-dichlorophenol from moist soil surfaces may occur(SRC) based on an estimated Henry's Law constant of 3.5X10-6 atm-cu m/mole(SRC), calculated using a vapor pressure of 0.09 mm Hg(4) and a water solubility of 5,547 mg/L(5). 2,4-Dichlorophenol is not expected to volatilize from dry soil surfaces based on a vapor pressure of 0.09 mm Hg at 25 °C(4). The pKa of 2,4-dichlorophenol is 7.89(6), indicating that this compound will partially exist in the anion form in the environment. In highly alkaline soils (pH 10), it has been observed to be poorly adsorbed to soil under such conditions(7). Non-dissociated 2,4-dichlorophenol is expected to undergo more adsorption than the ionized form(7,8). At 0-4 °C, 79-82% of initial 2,4-dichlorophenol was degraded in a clay loam soil during 12-14 days of aerobic incubation(9), suggesting that biodegradation may be an environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), Koc values of 263 in lake sediment, 661 in river sediment and 708 in aquifer material(2) indicate that 2,4-dichlorophenol is expected to adsorb to suspended solids and sediment in water(SRC). 2,4-Dichlorophenol may volatilize from water surfaces(3) based on an estimated Henry's Law constant of 3.5X10-6 atm-cu m/mole(SRC), calculated using a vapor pressure of 0.09 mm Hg(4) and a water solubility of 5,547 mg/L both at 25 °C(5). Using this Henry's law constant and an estimation method(3) volatilization half-lives for a model river and model lake are 14 days and 103 days, respectively(SRC). A pKa of 7.89(6) indicates 2,4-dichlorophenol will exist in a partially dissociated state which may affect its transport and reactivity in water and sediment(7). According to a classification scheme(6), a BCF range of 7.1 to 69 in carp(8) suggests the potential for bioconcentration in aquatic organisms is low to moderate(SRC). At 0-20 °C, 39-84% degradation in 40 days was reported using stream water inoculum while 35-60% was degraded in sterile stream water controls(9), suggesting that biodegradation in water is not an important environmental fate process(SRC).AQUATIC FATE: The rates of photolysis and microbial degradation of phenol, p-chlorophenol, 2,4-dichlorophenol, 2,4,5-trichlorophenol, and pentachlorophenol in estuarine water were determined. Photolysis was the primary transformation process for the polychlorinated phenols, with photolysis rate constants in surface estuarine water ranging from 0.3 to 1.2 per hour and half-lives ranging from 0.6 to 3 hr. Dichlorophenol photolysis rates were 20-80% higher in estuarine water than in distilled water, indicating a photosensitized reaction. There was no microbial (dark) degradation of polychlorinated phenols during short incubation periods (up to 3 days). The photoproducts of polychlorinated phenols were rapidly degraded by microbes. Microbial degradation was the primary process for transformation of phenol and p-chlorophenol. In the summer the microbial and photolysis transformation rate constants for phenol were 0.03 (half-life = 28 hr) and 0.016 per hour (half-life = 43 hr), respectively. Winter photolysis and microbial degradation rates were lower than the summer values.AQUATIC FATE: The consequences of contamination of the aquatic environment by chlorophenols /including ... 2,4-dichlorophenol/, have been evaluated by extensive review of the available scientific data. The chlorophenols generally exert moderate toxic effects to mammalian and aquatic life, although toxicity to fish upon long-term exposure may be considerable, as has been found for 2,4-dichlorophenol. Persistence is low when adapted microflora is present, capable of biodegrading these compounds, but may become moderate to high depending on the environmental conditions. Bioaccumulation is expected to be low. A striking feature of these chlorophenols is their strong organoleptic effect. /Chlorphenols/For more Environmental Fate (Complete) data for 2,4-DICHLOROPHENOL (6 total), please visit the HSDB record page.
Lebensmitteluntersuchungswerte2,4-Dichlorophenol was detected by GC-MS analysis in crop samples taken from the vicinity of a former dumping site of a chemical manufacturer in western Slovakia. The chemical manufacturer produced hexachlorocyclohexane (HCH), hexachlorobenzene, 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT). 2,4-Dichlorophenol was detected in soil (average = 0.011 mg/kg, maximum = 0.14 mg/kg) and vegetables (average = 0.067 mg/kg, maximum = 0.730 mg/kg sampled from the same area. The upper soil layer sampled was thought to have been brought in from an uncontaminated area upon decommission of the dumping site over 20 years prior(1).A study designed to provide residue testing methodology and establish tolerances for the registration of the herbicide, 2,4-dichlorophenoxyacetic acid, on potatoes detected 2,4-dichlorophenol at low levels. 2,4-Dichlorophenoxyacetic acid treated potato indicated average concentrations of less than 0.005 ppm of 2,4-dichlorophenol present in the tubers, and represented less than 10% of the 2,4-dichlorophenoxyacetic acid residue detected. To determine dissipation of 2,4-dichlorophenoxyacetic acid, chopped potato samples were fortified with 2,4-D and stored under frozen conditions and analyzed over a period of 35 weeks. The study revealed residue levels of 2,4-dichlorophenoxyacetic acid decreased with a half-life of approximately 12 weeks, while those of 2,4-dichlorophenol remained low throughout the period. A fractionation study showed 2,4-dichlorophenol was not concentrated in the peel of the potato tuber(1). /2,4-Dichlorophenoxyacetic acid/
Unerwünschte WirkungenOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
ExpositionspfadeThe substance can be absorbed into the body by inhalation, through the skin and by ingestion. Serious local effects by all routes of exposure.Oral (L159)dermal (L159)
Milk ConcentrationsEXPERIMENTAL: Over a 2-3 week period cows fed a complete ration containing the herbicide 2,4-dichlorophenoxyacetic ranging from 10-1000 ppm and other chlorophenols were tested for their presence in cow's milk and cream. Average 2,4-dichlorophenol residues detected were less than 0.05 ppm and only present at the highest dose of 1000 ppm 2,4-dichlorophenoxyacetic(1).
ToxizitätsübersichtChlorophenols have moderately high lipophilicity. Absorption through the gastrointestinal tract is by simple diffusion and is expected to be both rapid and virtually complete. The chlorophenols are also readily absorbed after dermal exposure. Chlorophenols uncouple mitochondrial oxidative phosphorylation and produce convulsions. At low concentrations, uncoupling produces stimulation of state 4 (resting state) respiration as a result of increased adenosine triphosphatase (ATPase) activity in the absence of a phosphate acceptor. Inhibition of state 3 (active) respiration is also observed. At moderate concentrations, resting respiration is neither stimulated nor inhibited. Significant inhibition of respiration, associated with a breakdown of the electron transport process and decreased ATPase activity, occurs at very high concentrations. (L159)
Ökotoxizitätsauszüge/AQUATIC SPECIES/ /In a study using fathead minnows (Pimephales promelas) the/ affected fish lost schooling behavior, were hypoactive, swam upside down, had deformities, and lost equilibrium prior to death. The dosage was between 0 mg/L for control groups and 15.0 mg/L for the highest dosed group./AQUATIC SPECIES/ The relative toxic responses to 27 selected phenols in 96 hr acute flow through Pimephales promelas (fathead minnow) and 48-60 hr chronic static Tetrahymena pyriformis (ciliate protozoan) test systems were evaluated. Log Kow-dependent linear regression analyses revealed that the data from each test system consisted of 2 linear equations. The less toxic chem form a relation which models polar /depression/these chem are slightly more active than the baseline toxicity of nonionic /depressant/ chem. The more toxic chem form a relation which model uncoupling of oxidative phosphorylation. Regression analysis of fathead minnow toxicity (log median lethal concentration (mol/L)) vs Tetrahymena pyriformis toxicity (log of the 48-60 hr 50% inhibitory concentration (BR), mmol/L) showed good correlation between the 2 systems./AQUATIC SPECIES/ Embryos of Fathead minnows were more resistant to phenol, 2,4-dimethylphenol, 2,4-dichlorophenol, and pentachlorophenol than were larval or juvenile life stages. Growth of 28-day-old fish was the most sensitive indicator of stress during exposures to phenol, 2,4-dimethylphenol, and pentachlorophenol, whereas survival was the most sensitive indicator of toxic effects from 2,4-dichlorophenol. Based on these effects, the estimated max acceptable toxicant concentration for Fathead minnows in Lake Superior water lies between 290 and 460 ug/L for 2,4-dichlorophenol./AQUATIC SPECIES/ Studies of the acute toxicity of 2,4-dichlorophenol, trichlorophenols, tetrachlorophenols, & pentachlorophenol to grass shrimp at known stages of the molt cycle showed that, with the exception of 2,4-dichlorophenol, the various chlorophenols were more toxic to molting shrimp than to non-molting, inter-molt shrimp. In general, the toxicity of chlorophenols could not be correlated to either the number of chlorine atoms or to the pKa values of these chlorophenols.For more Ecotoxicity Excerpts (Complete) data for 2,4-DICHLOROPHENOL (20 total), please visit the HSDB record page.
CERCLA-MeldepflichtmengenPersons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).
Clean Water Act AnforderungenToxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations.The USEPA /has/ determined ambient water quality criteria of ... 0.3 ug/l for 2,4-dichlorophenol, based upon organoleptic (taste threshold) data. ...
Landesrichtlinien für Trinkwasser(AZ) ARIZONA 21 ug/l(FL) FLORIDA 4 ug/l(ME) MAINE 21 ug/l(MN) MINNESOTA 20 ug/l
Bundesrichtlinien für TrinkwasserEPA 20 ug/l
VerpackungsgruppeII
Selbstentzündungstemperatur653°C