| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 51.7% (494 of 955) of all reports.WarningH315 (48.2%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 955 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|
| Regulatorische Informationen | Chemical: Calcium fluoride (CaF2)Directive (EC) No 46/2002Calcium fluoride (CaF2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Calcium fluoride (CaF2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 26-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15129Calcium fluoride: Does not have an individual approval but may be used under an appropriate group standard |
|---|
| Weitere Sicherheitsinformationen | IMAP assessments - Calcium fluoride (CaF2): Environment tier I assessment |
|---|
| Brandgefahren | Not combustible. |
|---|
| Gesundheitsgefahren | Little acute toxicity (USCG, 1999) |
|---|
| Gefahrenübersicht | Little acute toxicity[CAMEO] Normally stable, but decomposes into hydrogen fluoride when heated to 1200 deg C or mixed with concentrated acids[CHEMINFO] See FLUORIDES. |
|---|
| Reaktive Gruppe | Non-Redox-Active Inorganic Compounds |
|---|
| Reactivity Profile | CALCIUM FLUORIDE has weak oxidizing or reducing powers. Redox reactions can however still occur. The majority of compounds in this class are slightly soluble or insoluble in water. If soluble in water, then the solutions are usually neither strongly acidic nor strongly basic. These compounds are not water-reactive. |
|---|
| Chemical Dangers | On combustion, forms toxic fumes of fluoride. Reacts with mineral acids. This produces corrosive fumes. |
|---|
| Air and Water Reactions | No rapid reaction with air. No rapid reaction with water. |
|---|
| Hazard Classes and Categories | Skin Irrit. 2 (48.2%) |
|---|
| Brandbekämpfung | In case of fire in the surroundings, use appropriate extinguishing media. |
|---|
| Erste-Hilfe-Maßnahmen | Fresh air, rest.Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. |
|---|
| Erste Hilfe | Usually no treatment needed (USCG, 1999) |
|---|
| Sichere Lagerung | Separated from mineral acids. |
|---|
| Expositionsschutz und Persönliche Schutzausrüstung | Biological Exposure Indices (BEI) [ACGIH] - Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift(Repeated measurements recommended.)1.0 [mg/m3], as F, inhalable fraction[German Research Foundation (DFG)] |
|---|
| Lagerbedingungen | IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN COOL WELL VENTILATED PLACE, OUT OF DIRECT RAYS OF SUN, AWAY FROM ... HIGH FIRE HAZARD, & PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ... |
|---|
| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
|---|
| Verschüttetes entsorgen | Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. |
|---|
| Preventive Measures | IN THE MINING OF FLUORSPAR, DUST CONTROL SHOULD BE ... ENFORCED, INCLUDING WET DRILLING, WATERING OF LOOSE ROCK, AND EXHAUST & GENERAL VENTILATION. WHEN HEATING FLUORSPAR, THERE IS ALSO THE HAZARD OF HYDROFLUORIC ACID BEING FORMED, AND THE RELEVANT SAFETY MEASURES SHOULD BE APPLIED.SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. |
|---|
| Eye Prevention | Wear safety spectacles. |
|---|
| Inhalation Risk | Evaporation at 20 °C is negligiblea harmful concentration of airborne particles can, however, be reached quickly on spraying. |
|---|
| Skin Prevention | Protective gloves. |
|---|
| Expositionspfade | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
|---|
| Signs and Symptoms | Nausea. Vomiting. |
|---|
| Natural Pollution Sources | OCCURS IN NATURE AS THE MINERAL FLUORITE OR FLUORSPAR./FLUORSPAR OCCURS IN/ USCANADAEUROPEMEXICO.Calcium fluoride is the most abundant naturally occuring compound of fluoride |
|---|
| Human Toxicity Excerpts | ... HAZARDS OF FLUORSPAR ARE DUE PRIMARILY TO ... FLUORINE CONTENT AND ITS SILICA CONTENT. CHRONIC INHALATION OR INGESTION MAY CAUSE LOSS OF WEIGHT AND APPETITE, ANEMIA, AND BONE AND TEETH DEFECTS. PULMONARY LESIONS ... REPORTED AMONG PERSONS INHALING DUST CONTAINING 92-96% CALCIUM FLUORIDE & 3.5% SILICA. ... CASES OF BRONCHITIS & SILICOSIS ... REPORTED AMONG FLUORSPAR MINERS.CLINICAL DATA INDICATE THAT THE SODIUM SALT LIES NEAR THE BORDERLINE BETWEEN TOXICITY CLASSES 4 & 5 ... ALTHOUGH LESS TOXIC IN ANIMALS, BARIUM FLUORIDE MAY BE AS TOXIC IN MAN AS THE SODIUM SALT (OR PREHAPS SLIGHTLY MORE TOXIC). CALCIUM FLUORIDE IS COMPARATIVELY BENIGN ... BECAUSE OF ITS LOW SOLUBILITY & LOW IONIZATION. |
|---|
| Non-Human Toxicity Excerpts | TOXICITY OF INORG FLUORINE COMPD VARIES &, TO EXTENT, DEPENDS UPON THEIR SOLUBILITY IN WATER ABOVE CERTAIN MIN LEVELS OF INTAKE. SODIUM FLUORIDE & SODIUM FLUOSILICATE (SILICOFLUORIDE) ARE MOST TOXIC & CALCIUM FLUORIDE (FLUORSPAR) IS LEAST TOXIC ...EMBRYOTOXIC STUDIES OF CALCIUM FLUORIDE IN MICE OVER SEVERAL GENERATIONS INDICATED THAT ADMIN DURING PREGNANCY WAS RELATIVELY SAFE COMPARED TO OTHER FLUORIDES. ACUTE (IP) & CHRONIC (ORAL) LD50 VALUES ARE GIVEN.The pathogenicity of mixed dust from a fluorite mine was studied by animal experiments and in vitro tests. Animal experiments showed that calcium fluorite can induce only a foreign body reaction in the lungsthe fibrous nodular lesions induced by the fluorite mine dust are due mainly to its silica component. It was demonstrated that either silica or the mixed dust of a fluorite mine can stimulate pulmonary alveolar macrophages to release fibrogenetic factors in vitro, but calcium fluorite cannot. It was also demonstrated that having engulfed calcium fluorite, silica, or fluorite mine mixed dust, pulmonary alveolar macrophages release an elastase-active substance. It was suggested that the emphysematous lesion seen in autopsy material of pneumoconiosis of fluorite mine workers may be caused by calcium fluorite and silica. |
|---|
| Evidence for Carcinogenicity | A4Not classifiable as a human carcinogen. /Fluorides, as F/ |
|---|
| Probable Routes of Human Exposure | RISK OF FLUOROSIS IN 50 WORKERS ENGAGED FOR APPROX 30 YR IN PRODN OF PHOSPHATE FERTILIZERS WHERE AMBIENT CONCN OF FLUORIDE PARTICULATES (FLUORSPAR) RANGED FORM 0.15 TO 0.62 MG/CU M IS REPORTED. |
|---|
| Non-Human Toxicity Values | LD50 Rat oral 4250 mg/kgLD50 Mouse ip 2638 mg/kg |
|---|
