Carbarson

kutan · ameban · Arsuran · AMABEVAN · NSC32868 · Carbasone · aminarson · carbarson

Identifikatoren & physikalische Daten

CAS No.	121-59-5
Summenformel	C7H9AsN2O4
Durchschnittliche Molmasse	260,08 g/mol
Monoisotopische Masse	259,977826 g/mol
SMILES	NC(=O)Nc1ccc([As](=O)(O)O)cc1
InChIKey	WWXBHTZSYYGCSG-UHFFFAOYSA-N
PubChem CID	8480
ChEMBL	CHEMBL1331366
ChEBI	CHEBI:94806
EC No.	204-484-6
DTXSID	DTXSID4020246
Lokaler Name	Carbarson

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)	113
H-Brücken-Donoren	4
H-Brücken-Akzeptoren	4
Frei drehbare Bindungen	2
Schwere Atome	14
Formalladung	0
Komplexität	256
Löslichkeit	1 to 10 mg/mL at 71.1 °F (NTP, 1992)DMSO (Slightly), Methanol (Slightly, Sonicated)
Schmelzpunkt	345 °F (NTP, 1992)174°
Physical Description	Carbarsone appears as white powder or solid. (NTP, 1992)
Aggregatzustand	solid
pKa (Säurekonstante)	3.78±0.10(Predicted)
Stabilität	Hygroscopic
InChI	InChI=1S/C7H9AsN2O4/c9-7(11)10-6-3-1-5(2-4-6)8(12,13)14/h1-4H,(H3,9,10,11)(H2,12,13,14)
InChIKey	WWXBHTZSYYGCSG-UHFFFAOYSA-N
SMILES	C1([As](O)(O)=O)=CC=C(NC(N)=O)C=C1
EPA chemische Informationen	Carbarsone (121-59-5)

Sicherheit & Vorschriften

GHS-Einstufung	DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatorische Informationen	Restricted substance: Carbarsone
Weitere Sicherheitsinformationen	IMAP assessments - Arsonic acid, [4-[(aminocarbonyl)amino]phenyl]-: Environment tier I assessment
DOT-Kennzeichnung	Poison
Brandgefahren	Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992)
Gesundheitsgefahren	SYMPTOMS: Symptoms associated with arsenic compounds include irritation of the gastrointestinal tract, nausea, vomiting and diarrhea. In extreme cases, there may be blood in the vomitus and stool, rapid weak pulse, collapse, coma and death.
Reaktive Gruppe	Amides and Imides
Reactivity Profile	An acidic salt of an amide. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Air and Water Reactions	Slightly soluble in water.
Hazard Classes and Categories	Acute Tox. 3 (100%)
Brandbekämpfung	Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Erste Hilfe	EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Freisetung ohne Brand	SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Isolation and Evacuation	Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
Minimum Risk Level	Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)
Personal Protective Equipment (PPE)	RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Treatment	Aggressive decontamination with gastric lavage is recommended if the patient has consumed a potentially life-threatening dose and if the patient is not vomiting .
Gesundheitliche Auswirkungen	Hypovolemia from capillary leakage (third-spacing of fluids) is a common, serious, early effect. Muscle cramps, facial edema, bronchitis, dyspnea, chest pain, dehydration, intense thirst, and fluid-electrolyte disturbances are also common following significant exposures. A garlic-like odor of the breath and feces may also occur. After absorption, arsenic may cause multi-organ failure by inhibiting sulfhydryl-containing enzymes. Encephalopathy, with headache, lethargy, mental confusion, hallucinations, emotional lability, memory loss and delirium may occurseizures, stupor, convulsions, coma, and death may follow within 24 hours of a severe acute exposure. Dysrhythmias (particularly QTc prolongation and torsade de pointes), cardiomyopathy, ARDS, hepatitis, rhabdomyolysis, hemolysis, and renal failure may develop over several days. The sequence of chronic poisoning involves hyperpigmentation, and eczematoid and allergic dermatitis. muscle fasciculationsgross tremorsataxiaincoordinationand mental confusion. Muscular weakness, limb tenderness and difficulty walking may follow. The final phase consists of peripheral sensory neuropathy of the hands and feet. That may be associated with a motor neuropathy as well .
Expositionspfade	Oral (L2)inhalation (L2)dermal (L2)
Toxizitätsübersicht	Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carcinogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)
Signs and Symptoms	Initial signs and symptoms of arsenic ingestion include burning lips, throat constriction and dysphagia, followed by excruciating abdominal pain, hemorrhagic gastritis, gastroenteritis, severe nausea, projectile voting, profuse "rice water-like" diarrhea, with hypovolemia that may result in hypotension and an irregular pulse. The sequence of chronic poisoning involves weakness, anorexia, hepatomegaly, jaundice, and gastrointestinal complaints, followed by conjunctivitis, irritation of the throat and respiratory tract. ther effects of chronic exposure include conjunctivitis with irritation and lacrimationhair, skin and nail changeshyperkeratosis of feet and handsand melanosis, with pigment spots in corneal and conjunctival epithelium. Peripheral nervous system symptoms may include numbness, burning, and tingling of the hands and feetparesthesiastenderness .
Carcinogen Classification	3, not classifiable as to its carcinogenicity to humans. (L135)
Alarmwort	Achtung
Gefahrenhinweise	Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H301

Anwendungen & Verwendung

Verwenden

insecticide, cholinesterase inhibitor