Sulfan Blue

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 15(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(3), indicates that C.I. Acid Blue 1 will have very high mobility in soil(SRC). Due to the ionic nature of C.I. Acid Blue 1, the retention of the dye by ion-exchange processes(4,SRC), particularly on clay surfaces, and adsorption at mineral surfaces such as geothite(5,SRC), may slow down or prevent leaching(SRC). As C.I. Acid Blue 1 is an ionic compound, volatilization of this compound will not be important from moist soil surfaces(4,SRC).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 15(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(1), indicates that C.I. Acid Blue 1 should not adsorb to suspended solids and sediment in water(SRC). However, due to the ionic nature of C.I. Acid Blue 1, the retention of the dye by ion-exchange processes(3,SRC), particularly on clay surfaces, and adsorption at mineral surfaces such as geothite(4,SRC), may lead to increased adsorption on some surfaces(SRC). As C.I. Acid Blue 1 is an ionic compound, volatilization from water surfaces is not expected(3,SRC). According to a classification scheme(5), an estimated BCF value of 2(1,SRC), from a measured water solubility(2), suggests that bioconcentration in aquatic organisms is low(SRC).

ATMOSPHERIC FATE: The ionic state of C.I. Acid Blue 1 makes this compound essentially non-volatile(1,SRC); therefore, this compound should exist in the particulate phase in the ambient atmosphere. Particulate-phase C.I. Acid Blue 1 may be physically removed from the air, mainly by wet deposition(SRC).

The Koc of C.I. Acid Blue 1 is estimated as approximately 15(SRC), using a measured water solubility of 30,000 mg/l(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that C.I. Acid Blue 1 has very high mobility in soil(SRC). Due to the ionic nature of the dye, the retention of C.I. Acid Blue 1 by ion-exchange processes(4,SRC), particularly on clay surfaces and adsorption at mineral surfaces such as geothite(5,SRC), may slow down or prevent leaching(SRC).

DRUG HYPERSENSITIVITY ON PATIENTS BEING TESTED BY SKIN-PRICK & RECEIVING LYMPHOGRAM.

A CASE OF AN ALLERGIC REACTION TO PATENT BLUE VIOLET DYE USED FOR THE PURPOSE OF LYMPHANGIOGRAPHY IS REPORTED. SYMPTOMS WERE URTICARIAL REACTION, EDEMA OF THE EYELIDS & LIPS, AND HYPOTENSION.

Immediate reactions to patent blue dye /is presented/.

sensitivity to patent blue dye during skin prick testing and lymphography. A retrospective and prospective study.

For more Human Toxicity Excerpts (Complete) data for C.I. FOOD BLUE 3 (7 total), please visit the HSDB record page.

C.I. Acid Blue 1's production and use as a dye for wool, silk, leather, and jute, as a paper stain, to color phenol-formaldehyde resins, milled soaps, inks, and casein, as a biological stain(1) and to color medicinal products(2) may result in its release to the environment through various waste streams(SRC).

Blue VRS

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals

1987

1987

An estimated BCF value of 2 was calculated for C.I. Acid Blue 1(SRC), using a measured water solubility of 30,000 mg/l(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

GROUP OF 10 MALE & 10 FEMALE 5-WK-OLD WISTAR RATS RECEIVED WEEKLY SC INJECTIONS OF 0.5 ML OF 4% SOLN OF BLUE VRS (PURITY NOT GIVEN) IN ISOTONIC SALINE FOR 45 WK (TOTAL DOSE 900 MG). ... 2 FEMALES DEVELOPED RHABDOMYOSARCOMAS IN AREA OF INJECTION SITE. IN 20 CONTROL ANIMALS /8 ALIVE @ 71 WK/, NO INJECTION-SITE TUMORS SEEN.

SHELL OR CARWORTH FARM E ALBINO RATS OF BOTH SEXES, WEIGHING 100-150 G, WERE GIVEN TWICE WEEKLY SC INJECTIONS OF EITHER 0.5 ML OF 2% SOLN (20 RATS) OR 1 ML OF 1% AQ SOLN (65 RATS) OF BLUE VRS (82% PURE) FOR 55 OR 72 WK, RESPECTIVELY. 6 OUT OF 19 & 8/60 RATS DEVELOPED SARCOMAS AT SITE OF REPEATED INJECTIONS.

TWENTY RATS RECEIVED TWICE WEEKLY SC INJECTIONS OF 0.5% ML OF A 2% AQ SOLN OF THE DYE FOR 65 WK, BUT INJECTIONS WERE DISTRIBUTED AMONG 4 SC SITES IN TURN (DORSAL TO THE SCAPULAE & IN THE LUMBAR REGION). AT 81 WK, NO SARCOMAS OBSERVED IN THESE RATS AT ANY OF THE INJECTION SITES.

...20 MALE & 20 FEMALE 10-WK-OLD WISTAR RATS RECEIVED WEEKLY INJECTIONS OF 0.4 ML OF 4% ...(FOOD GRADE) IN 0.9% SALINE INTO POSTERIOR THIGH MUSCLES OF THE RIGHT LEG. ...5/19 MALES & 9/18 FEMALES DEVELOPED RHABDOMYOSARCOMAS @ INJECTION SITE. ... METASTASES OCCURRED IN LYMPH NODES, LUNGS & LIVER. /NONE/ IN CONTROLS.

For more Non-Human Toxicity Excerpts (Complete) data for C.I. FOOD BLUE 3 (13 total), please visit the HSDB record page.

NIOSH (NOES Survey 1981-1983) has statistically estimated that 62,878 workers (9626 of these are female) are potentially exposed to C.I. Acid Blue 1 in the US(1). Occupational exposure may be through inhalation of dusts and dermal contact with this compound at workplaces where C.I. Acid Blue 1 is produced or used(2,SRC). The general population may be exposed to C.I. Acid Blue 1 via ingestion of pharmaceuticals and dermal contact with products containing C.I. Acid Blue 1(SRC).