Grundinformationen
- CAS
129-46-4- Standard-SMILES
Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)[O-])c3cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)[O-])c5cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c45)ccc3C)c2)c1.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]- InChIKey
VAPNKLKDKUDFHK-UHFFFAOYSA-H- Summenformel
- C51H34N6Na6O23S6
- Durchschnittliche Molmasse
- 1.429,2 g/mol
- Monoisotopische Masse
- 1.427,9385741
Überblick
Suramin sodium is an organic sodium salt that is the hexasodium salt of suramin. It is an FDA approved drug for African sleeping sickness and river blindness. It has a role as an antinematodal drug, an antineoplastic agent, a trypanocidal drug, an EC 2.7.11.13 (protein kinase C) inhibitor, a GABA-gated chloride channel antagonist, an angiogenesis inhibitor, a GABA antagonist, a ryanodine receptor agonist, an apoptosis inhibitor and a purinergic receptor P2 antagonist. It contains a suramin(6-).
Namen und Bezeichner
- Bevorzugter Name
- Suramin Sodium
- IUPAC
- hexasodium;8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate
- Lokaler Name
- Suraminnatrium
- Englischer Name
- Suramin sodium
- Summenformel
- C51H34N6Na6O23S6
- Molmasse
- 1429.17
Namen und Synonyme
SURAMIN SODIUM129-46-4Suramin hexasodiumAntrypolSuramine sodiqueNagananinumNaganinNaganineNaganinumGermaninMoranylFourneau 309
Weitere Namen anzeigen
SURAMINSURAMIN SODIUM SALTSURAMIN HEXASODIUM SALTnf060reasodiumsaltsuraminesodiumnaphuridesodiumSuramin, Sodium Salt - CAS 129-46-4 - Calbiochem309fF-309
Naphuride sodiumSuraminum natricumSodium suraminSuramina sodicaBayer-205Bayer 205CI-1003BAY 205
Datenbank-Bezeichner
- CAS
129-46-4- PubChem CID
- 8514
- DTXSID
DTXSID30156024- ChEMBL
CHEMBL413376- ChEBI
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 551 Ų
- H-Brücken-Donoren
- 6
- H-Brücken-Akzeptoren
- 23
- Frei drehbare Bindungen
- 10
- Schwere Atome
- 92
- Formalladung
- 0
- Komplexität
- 2.940
Experimentelle und physikochemische Eigenschaften
Solubility
Water Very soluble (mg/mL)
Ethyl alcohol Slightly soluble (mg/mL)
Chloroform Insoluble (mg/mL)
Ethyl ether Insoluble (mg/mL)
Human DrugsAntifilarials
Physikochemische Eigenschaften
- Schmelzpunkt
- 260 °C · >260°C (dec.)
- storage temp.
- 0 · 0-6°C
- Löslichkeit
- 2 O: · H2O: >10mg/mL
- Aggregatzustand
- Crystalline Powder
- Farbe
- White
- PH
- pH(10g/l, 25℃) : 5.0～8.0
- Wasserlöslichkeit
- soluble
- BRN
- 3694087 · 3694087
- Stabilität
- Hygroscopic
- InChIKey
- VAPNKLKDKUDFHK-UHFFFAOYSA-H
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 25 reports by companies from 1 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesSkin Sens. 1 (100%)
Toxikologische Informationen
Toxicity Data
Mouse(ip): LD50:750mg/kg
Man(iv): TDLo:46 mg/kg/5 week intermittent schedule
Mouse(iv): LD50:620mg/kg
Sicherheitsdaten
- F
- 3-10
- wgk
- 3
- hs_code
- 29242998
- RTECS-Nr.
- QM7000000
- Toxizität
- LD50 in mice (mg/kg): ~620 i.v. (Hawking)
- safety_code
- 22-24/25
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
ATC Code
P - Antiparasitic products, insecticides and repellents
QP - Antiparasitic products, insecticides and repellents
P01CX02
MeSH Pharmacological Classification
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.
Anwendungen
BeschreibungIntroduced into therapy for the treatment of early trypanosomiasis in the 1920s, suramin, a bis-hexasulfonatednaphthylurea, is still considered to be the drug of choice for treatment of non-CNS-associated African trypanosomiasis.
VerwendenSuramin sodium is a compound with a dyelike structure. Suramin is most effective against T. b. rhodesiense, but has also been used against T. b. gambiense infection. The compound causes side effects such as nausea, photophobia, and peripheral neuropathy which disappear shortly after conclusion of administration. Because the drug is unable to pass the bloodbrain barrier, prompt treatment of patients is essential. Suramin in combination with tryparsamide is an alternative that has been investigated.
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