4-(2-Hydroxyethyl)-1-piperazinpro-pansulfonsäure
Hepps
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Grundinformationen
- CAS
16052-06-5- Standard-SMILES
O=S(=O)(O)CCCN1CCN(CCO)CC1- InChIKey
OWXMKDGYPWMGEB-UHFFFAOYSA-N- Summenformel
- C9H20N2O4S
- Durchschnittliche Molmasse
- 252,33 g/mol
- Monoisotopische Masse
- 252,11437812
Überblick
HEPPS is a N-(2-hydroxyethyl)piperazine and a N-(sulfoalkyl)piperazine.
Namen und Bezeichner
- Bevorzugter Name
- Hepps
- IUPAC
- 3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
- Lokaler Name
- 4-(2-Hydroxyethyl)-1-piperazinpro-pansulfonsäure
- Englischer Name
- HEPPS
- Summenformel
- C9H20N2O4S
- Molmasse
- 252.33
Namen und Synonyme
Hepps16052-06-53-(4-(2-Hydroxyethyl)piperazin-1-yl)propane-1-sulfonic acid1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PROPANE-1-SULFONIC ACID3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic AcidN-(2-Hydroxyethyl)piperazine-N'-(3-propanesulfonic acid)4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acidEINECS 240-198-88JN5PQW99CBRN 3957385N-2-Hydroxyethylpiperazine-N'-3-propanesulfonic acid
Weitere Namen anzeigen
EPPS4-(2-HYDROXYETHYL)-1-PIPERAZINEPROPANESULFONIC ACIDHEPEaEPPSEPPS,99%HEPPS(EPPS)HEPPS BufferEPPS USP/EP/BPEPPS SIGMAULTRA
DTXSID3066003CHEBI:42298N-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acidN-2-Hydroxyethylpiperazine-N-3-propanesulfonic acid4-(2-Hydroxyethyl)piperazine-1-propane-3-sulfonic acid3-(4-(2-Hydroxyethyl)-1-piperazinyl)propanesulfonic acidRefChem:145584DTXCID5035169
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- -3,6
- Polarare Oberfläche (TPSA)
- 89,5 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 16
- Formalladung
- 0
- Komplexität
- 280
Experimentelle und physikochemische Eigenschaften
Chemical ClassesNitrogen Compounds -> Piperazines
Physical DescriptionBeige powder; [Sigma-Aldrich MSDS]
Physikochemische Eigenschaften
- Schmelzpunkt
- 237 · 237-239 °C(lit.)
- Dichte
- 1.2684 · 1.2684 (rough estimate)
- Brechungsindex
- 1.68 · 1.6800 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- 2 O: · H2O: 1 M at 20 °C, clear, colorless
- Aggregatzustand
- Powder/Solid
- Farbe
- White
- PH
- 5 · 5.0-6.5 (25℃, 0.1M in H2O)
- pka
- 8 · 8.0(at 25℃)
- Wasserlöslichkeit
- 25.2 g/L · Soluble in water. 25.2 g/L (20°C)
- BRN
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 94.2% (65 of 69) of all reports.
Not Classified
Aggregated GHS information provided per 69 reports by companies from 6 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory Information
Chemical: 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-
Status: Active Update: 09-09-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/32799
1-Piperazinepropanesulphonic acid, 4-(2-hydroxyethyl)-: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryOral LD50 (quail) > 316 mg/kg; [RTECS] An eye irritant; [Sigma-Aldrich MSDS] See Piperazine and salts. See HEPES.
Hazard Classes and CategoriesNot Classified
Sicherheitsdaten
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 29335995
- RTECS-Nr.
- TM2649130
- risk_code
- 36/37/38-22
- Toxizität
- quail,LD50,oral,> 316mg/kg (316mg/kg),Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
- hazard_code
- Xi
- safety_code
- 24/25-36-26
- hazard_class
- IRRITANT
Chemie und Industrie
Verwendung und Herstellung
General Manufacturing Information1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-: ACTIVE
Anwendungen
VerwendenHEPPS (EPPS) is a commonly used Good's buffer. It is often used as separator in ultrathin isoelectric focusing gels and enhances the resolution of phosphoglucomutase. It is used as a buffering agent in biology and biochemistry. HEPPS is a biological buffer with a useful pH range of 7.3-8.7 and a pKa=8.0 at 25°C. Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice. HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.
Zugehörige Reaktionen
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