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2-Anisidine hydrochloride
c.i.37115 · nci-c03747 · fastredbbbase · o-AnisidineHCl · O-aminehydrochloride · ANISIDINE HYDROCHLORIDE · 2-anisidinehydrochloride · o-Anisidine hydrochloride
Identifikatoren & physikalische Daten
| CAS No. | 134-29-2 |
|---|---|
| Summenformel | C7H9NO.ClH |
| Durchschnittliche Molmasse | 159,61 g/mol |
| Monoisotopische Masse | 159,04509162 g/mol |
| SMILES | COc1ccccc1N.Cl |
| InChIKey | XCZCWGVXRBJCCD-UHFFFAOYSA-N |
| PubChem CID | 8638 |
| ChEMBL | CHEMBL3183318 |
| EC No. | 603-807-1 |
| DTXSID | DTXSID8020092 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 35,3 |
|---|---|
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 10 |
| Formalladung | 0 |
| Komplexität | 85 |
| Stoffklassen | Carcinogens |
| Löslichkeit | 10 to 50 mg/mL at 70 °F (NTP, 1992)almost transparency |
| Schmelzpunkt | 437 to 441 °F (NTP, 1992)228-230 °C |
| Physical Description | O-anisidine hydrochloride appears as gray-black crystalline solid or light gray powder. May be carcinogenic. |
| Lagerbedingungen | Store at room temperature |
| Aggregatzustand | powder to crystal |
| Farbe | White to Almost white |
| CAS Datenbank | 134-29-2(CAS DataBase Reference) |
| EPA chemische Informationen | o-Anisidine hydrochloride (134-29-2) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301+H311+H331 (50%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oralacute toxicity, dermalacute toxicity, inhalation]P203, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P321, P330, P337+P317, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] |
|---|---|
| Regulatorische Informationen | Hazard Traits - CarcinogenicityThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| Brandgefahren | Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992) |
| Gesundheitsgefahren | SYMPTOMS: This compound may cause local irritating effects to the eyes, mucous membranes and skin. It may also cause allergic responses. |
| Reaktive Gruppe | Ethers |
| Reactivity Profile | O-ANISIDINE HYDROCHLORIDE reacts as an acid to neutralize bases. These neutralizations generate some heat. Usually does not react as either an oxidizing agent or reducing agent but such behavior is not impossible. May catalyze organic reactions. |
| Air and Water Reactions | Water soluble. |
| Hazard Classes and Categories | Acute Tox. 3 (100%)Germ cell mutagenicity - Category 2Carcinogens |
| Brandbekämpfung | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Personal Protective Equipment (PPE) | MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. |
| Carcinogen Classification | ortho-Anisidine hydrochlorideGroup 2A: Probably carcinogenic to humansVolume 127: (2021) Some Aromatic Amines and Related Compounds2021 online2020o-Anisidine hydrochloride |
| RAIS Toxicity Values | 3.1e-05CALEPA0.11 |
| UN-Transportnummer | 2811 |
| Zollcode | 2922.50.4000 |
| RTECS-Nr. | BZ6500000 |
| R-Sätze (R) | 36/37/38-22 |
| Toxizität | mma-sat 10 mg/plate ENMUDM 7(Suppl 5),1,85 |
| Gefahrensymbole | Xn |
| Sicherheitshinweise (S) | 26-36/37/39 |
| Gefahrenklasse | 6.1 |
| Verpackungsgruppe | III |
Anwendungen & Verwendung
Verwenden
o-Anisidine hydrochloride is used as a chemical intermediate in the production of numerous azo and triphenylmethane dyes and pigments (e.g., C.I. direct red 72, disperse orange 29, direct yellow 44, direct red 24, and acid red 4); in the production of pharmaceuticals, including the expectorant guaiacol; as a corrosion inhibitor for steel; and as an antioxidant for polymercaptan resins (IARC 1999, HSDB 2009).