Sulfone, bis((4-chloroacetylamino)phenyl)
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Grundinformationen
- CAS
17328-16-4- Standard-SMILES
O=C(CCl)Nc1ccc(S(=O)(=O)c2ccc(NC(=O)CCl)cc2)cc1- InChIKey
SHRCVZJKZJGIHQ-UHFFFAOYSA-N- Summenformel
- C16H14Cl2N2O4S
- Durchschnittliche Molmasse
- 401,271 g/mol
- Monoisotopische Masse
- 400,00513329
Namen und Bezeichner
- Bevorzugter Name
- Sulfone, bis((4-chloroacetylamino)phenyl)
- IUPAC
- N,N'-[Sulfonyldi(4,1-phenylene)]bis(2-chloroacetamide)
- Englischer Name
- N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
- Summenformel
- C16H14Cl2N2O4S
- Molmasse
- 401.27
Namen und Synonyme
TC-E 5003N'-(Sulfonyldi-4TC-E 5003 (NSC-30176)TC-E 5003, 10 mM in DMSO1-phenylene)bis(2-chloroacetamide)4',4'-SULFONYLBIS(2-CHLOROACETANILIDE)4',4'-SULFONYLBIS(2-CHLOROACETANILIDE)Bis[4-(chloroacetylamino)phenyl] sulfone4',4'''-Sulfonylbis(α-chloroacetanilide)N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
Datenbank-Bezeichner
- CAS
17328-16-4- PubChem CID
- 87052
- DTXSID
DTXSID40169569- ChEMBL
CHEMBL1797447- UNII
- JW87Q22JDK
- Nikkaji
- J48.748A
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 191 · 191-192 °C
- Siedepunkt
- 704.2 · 704.2±60.0 °C(Predicted)
- Dichte
- 1.504 · 1.504±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C (des.)
- Löslichkeit
- Soluble in DMSO (up to 50 mg/ml).
- pka
- 11.56 · 11.56±0.70(Predicted)
- Aggregatzustand
- solid
- Farbe
- Brown
- Stabilität
- 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Chemie und Industrie
Anwendungen
BeschreibungTC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 1.5 μM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 μM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 μM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.
VerwendenNSC 30176 is a inhibitor of human PRMT1, it is selective for PRMT1 over the arginine methyltransferase CARM1 and the lysine methyltransferase Set7/9.
Anbieter47 Anbieter
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]
韶远科技（上海）有限公司4000665055 · [email protected]
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]
上海辅欣医药科技有限公司+86-021-021-50872116 · [email protected]
InvivoChem中国13549236410 · [email protected]
MedBio脉铂医药
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