Identifikatoren & physikalische Daten
| CAS No. | 139-12-8 |
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| Summenformel | C6H9AlO6 |
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| Durchschnittliche Molmasse | 204,11 g/mol |
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| Monoisotopische Masse | 204,02145164 g/mol |
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| SMILES | CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].[Al+3] |
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| InChIKey | WCOATMADISNSBV-UHFFFAOYSA-K |
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| PubChem CID | 8757 |
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| ChEMBL | CHEMBL1201015 |
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| EC No. | 205-354-1 |
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| DTXSID | DTXSID30890496 |
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Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 120 |
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| H-Brücken-Donoren | 0 |
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| H-Brücken-Akzeptoren | 6 |
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| Frei drehbare Bindungen | 0 |
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| Schwere Atome | 13 |
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| Formalladung | 0 |
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| Komplexität | 25,5 |
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| Stoffklassen | Metals -> Organic Acids, Metal Salts |
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| Kosmetika | Antimicrobial |
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| Human Drugs | FDA approved drugs -> Active ingredient |
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| Food Contact Substances | FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR |
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| Physical Description | Neutral form: White solid, soluble in water[Hawley] |
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Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 40.2% (70 of 174) of reports.WarningH315 (59.8%): Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)Aggregated GHS information provided per 174 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
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| Regulatorische Informationen | Chemical: Acetic acid, aluminium salt |
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| Gefahrenübersicht | There are three aluminum acetatesAl(CO2CH3)3 has CAS 139-12-8[Ullmann] See Aluminum. |
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| Hazard Classes and Categories | Skin Irrit. 2 (59.8%) |
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| Minimum Risk Level | Intermediate Oral: 1.0 mg/kg/day (L134)
Chronic Oral: 1.0 mg/kg/day (L134) |
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| Gesundheitliche Auswirkungen | Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) |
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| Expositionspfade | Oral (L739)inhalation (L739) |
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| Toxizitätsübersicht | The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236) |
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| Signs and Symptoms | Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) |
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| Carcinogen Classification | Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468). |
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