3,3,4,4,5,5,6,6,6-Nonafluorhexen

1.4 g/L

Relative density of the vapor/air-mixture = 3.3 at 20 °C (air = 1)

1.4 g/l

Relative density of the vapour/air-mixture at 20 °C (air = 1): 3.3

58 °C

58 °C

When heated to decomposition it emits toxic vapors of /hydrofluorides/. /3,3,4,4,5,5,6,6-Nonafluoro-1-hexene/

Hazardous decomposition products formed under fire conditions: Carbon oxides, hydrogen fluoride.

8.5 (Air = 1)

Relative vapor density (air = 1): 8.5

238.0 [mmHg]

31.7 kPa at 20 °C (238 mm Hg at 20 °C)

Vapor pressure, kPa at 20 °C: 31.7

Liquid; CBI

Colorless liquid with an ethereal odor;

COLOURLESS LIQUID.

This chemical does not meet GHS hazard criteria for 27.4% (17 of 62) of reports.

Danger

H225 (71%): Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 62 reports by companies from 3 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 17 of 62 reports by companies.；There are 2 notifications provided by 45 of 62 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Regulation (EC) No 1935/2004 (amended)

1-Hexene, 3,3,4,4,5,5,6,6,6-nonafluoro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Hexene, 3,3,4,4,5,5,6,6,6-nonafluoro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 09-12-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/5646

1-Hexene, 3,3,4,4,5,5,6,6,6-nonafluoro-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Flam. Liq. 2 (71%)

Flammable liquids - Category 2；Serious eye damage/eye irritation - Category 2B

Flammable agents - 4th degree

Fresh air, rest.

Rinse skin with plenty of water or shower.

Rinse with plenty of water (remove contact lenses if easily possible).

Rinse mouth.

Suitable extinguishing media For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water.

Special protective equipment for fire-fighters: Wear self contained breathing apparatus for fire fighting if necessary.

Use water spray to cool unopened containers.

ACCIDENTAL RELEASE MEASURES. Personal precautions: Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.

ACCIDENTAL RELEASE MEASURES: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations

ACCIDENTAL RELEASE MEASURES. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Precautions for safe handling: Avoid inhalation of vapour or mist. Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

Skin and body protection: Impervious clothing, flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 7800(SRC), determined from a structure estimation method(2), indicates that perfluorobutyl ethylene is expected to be immobile in soil(SRC). Volatilization of perfluorobutyl ethylene from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 110 atm-cu m/mole(SRC), using a fragment constant estimation method(3). However, adsorption to soil is expected to attenuate volatilization(SRC). Perfluorobutyl ethylene is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 238 mm Hg at 20 °C(4). Biodegradation data in soil were not available(SRC, 2011).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 7800(SRC), determined from a structure estimation method(2), indicates that perfluorobutyl ethylene is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 110 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4.9 hours and 6.2 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The volatilization half-life from a model pond is about 80 days when adsorption is considered(5). According to a classification scheme(6), an estimated BCF of 370(SRC), from an estimated log Kow of 4.4(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC). Biodegradation data in water were not available(SRC, 2011).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), perfluorobutyl ethylene, which has a vapor pressure of 238 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase perfluorobutyl ethylene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 19 hours(SRC), calculated from its rate constant of 2.0X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). The rate constant for the vapor-phase reaction of perfluorobutyl ethylene with ozone has been estimated as 1.8X10-18 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3); the half-life for this reaction in air is about 6.5 days(4). Perfluorobutyl ethylene does not contain chromophores that absorb at wavelengths >290 nm(5), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of perfluorobutyl ethylene can be estimated to be 7800(SRC). According to a classification scheme(2), this estimated Koc value suggests that perfluorobutyl ethylene is expected to be immobile in soil.

An estimated BCF of 370 was calculated in fish for perfluorobutyl ethylene(SRC), using an estimated log Kow of 4.4(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC), provided the compound is not metabolized by the organism(SRC).

The Henry's Law constant for perfluorobutyl ethylene is estimated as 110 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that perfluorobutyl ethylene is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 4.9 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 6.2 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The volatilization half-life from a model pond is about 80 days when adsorption is considered(3). Perfluorobutyl ethylene is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 238 mm Hg at 20 °C(4).

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ CD rats (10 male and 10 female per dose group) were exposed 6 hr/day, 5 days/week at 0, 500, 5000, or 50,000 ppm PFBE vapor in a 2-week ... inhalation study. The measured mean vapor exposure concentrations for the male rats were 541, 4750, and 46,300 ppm. For the females, the mean concentrations were 473, 5,140, and 46,800 ppm. Control and exposed animals did not show any clinical signs of toxicity during or after the exposure period. Weight gain was normal in all groups. Clinical-chemical measurements in rats exposed at 500 ppm did not show any compound-related changes. Female rats exposed at 5000 or 50,000 ppm PFBE had significantly more monocytes in the blood relative to controls (200% and 167%, respectively). Females in the highest dose group tended to excrete more fluoride (5.7 mg/L versus 1.4 mg/L in controls with no dose-response relationship). These effects were reversible after a 14-day post-exposure period. At the end of the exposure period, male rats exposed to 50,000 ppm had significantly decreased platelet counts (89.7% of controls), and fluoride excretion in the urine was increased. Leukocyte counts and creatinine were significantly different between exposed animals and controls but did not show a dose-response relationship. Accordingly, they were not judged to be compound-related. Pathological examinations did not reveal any macroscopic or microscopic changes that could be related to PFBE exposure. Following completion of exposures, kidney-to-body weight-ratios were significantly increased in males (1.21-fold) and females (1.13-fold) exposed at 50,000 ppm. Relative liver weights were significantly increased only in males (1.23-fold) exposed at 50,000 ppm. Relative organ weights were still increased in male rats (liver, 1.12-fold; kidney, 1.15-fold) after 14 days postexposure. These effects were completely reversible in female rats. The no-observed-adverse-effect level (NOAEL) for this study was d

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ In an inhalation study, male and female rats were exposed 6 hours/day for 28 consecutive days at 400, 2000, or 10,000 ppm PFBE vapor. ... In the 10,000 ppm-exposed group, minor effects included very slight to slight histopathological changes in individual organs. ... Very slight focal alveolar histiocytosis was observed in the lungs of one of five animals in each of the high-dose groups. Minimal focal to multifocal submucous inflammatory cell infiltration was also noted sporadically in the region of the larynx (1/5 males and 2/5 females). ... Four of the five male test animals in the 10,000-ppm group exhibited a minimal multifocal hepatocellular cytoplasmic vacuolation. A decrease in mean partial thromboplastin time was measured in the 10,000-ppm exposed males and was considered an indicator of increased protein synthesis in the liver. The NOAEL for this study was determined to be 2000 ppm.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Inhalation studies were conducted to determine the potential subchronic toxicity of a mixture of trans-1,2-dichloroethylene (70%), cis-1,2-dichloroethylene (5%), and perfluorobutylethylene (25%). Groups of rats were exposed to 0, 400, 2000, or 8000 ppm concentrations of the mixture vapor 6 hr/day, 5 days/wk, for a total of 20 exposures. Subgroups of rats were further observed during a 1-mo recovery period. Functional observational battery (FOB) and motor activity (MA) behavioral tests were conducted prior to initiation of the exposures, during exposure wk 4, and after a 1-mo postexposure recovery period. Clinical pathology evaluations were conducted at the end of the exposure period and after a 1-mo recovery period. At the end of the 4-wk exposure period, tissues from rats were collected, histologically processed, and evaluated by light microscopy. Test substance-related, biologically significant decreased body weights and body weight gains occurred in male and female rats exposed to 8000 ppm. In addition, test substance-related, statistically significant decreases in food consumption and/or food efficiency were observed in male rats exposed to 8000 ppm. During exposures to 8000 ppm, some rats exhibited tremors and ataxia. Usually tremors and ataxia were observed within 1 hr after initiation of the daily exposure period and were observed during each exposure day. Tremors were also observed during 1 exposure day in the 2000 ppm animals. In addition to the tremors and ataxia, rats exposed to 2000 ppm or 8000 ppm had a diminished and/or no alerting response to a sharp, sound stimulus during each of the daily exposure periods. These effects were transient since no clinical observations of compromised neurological function were detected when the rats were evaluated upon return to the animal room following exposure. Daily reoccurrence of this apparently acute effect in the 8000 ppm group did not produce enduring neur

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Pregnant CD rats were exposed 6 hours/day to PFBE at 0, 1,000, or 70,000 ppm on days 6 to 15 of gestation.(7) The 1000-ppm exposure did not cause any compound-related effects. Body weight gains in rats exposed to 70,000 ppm were significantly decreased (about 30%) during the exposure period. Mean food consumption in this group was lower than in controls during exposure and postexposure periods. No other adverse maternal effects were observed. No increase in malformation rate was observed in the treated groups during the fetal external or skeletal evaluations. During the soft tissue evaluations, a slight increase in the incidence of fetuses with malformations was observed only in the low dose group. The most common observation noted during this evaluation involved distention and/or tortuous condition of the ureter (7 of 43 fetuses). Similar observations were made in the control group with lower incidence (2 of 48 fetuses). In the high-dose group, 2 of 44 fetuses of the highdose group also showed these effects. Since this effect was not dose-related and frequently occurred in the historical database for this rat strain, it was not compound-related.

For more Non-Human Toxicity Excerpts (Complete) data for Perfluorobutyl ethylene (6 total), please visit the HSDB record page.

The rate constant for the vapor-phase reaction of perfluorobutyl ethylene with photochemically-produced hydroxyl radicals has been estimated as 2.0X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 19 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the vapor-phase reaction of perfluorobutyl ethylene with ozone has been estimated as 1.8X10-18 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(1). This corresponds to an atmospheric half-life of about 6.5 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2). Perfluorobutyl ethylene is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). Perfluorobutyl ethylene does not contain chromophores that absorb at wavelengths >290 nm(3), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of perfluorobutyl ethylene is 100 to 999; the data may be greatly underestimated(1).

Perfluorobutyl ethylene's production and use in the manufacture of fluorinated polymers may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 238 mm Hg at 20 °C indicates perfluorobutyl ethylene will exist solely as a vapor in the atmosphere. Vapor-phase perfluorobutyl ethylene will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 19 hours. The half-life for the vapor-phase reaction of perfluorobutyl ethylene with ozone has been estimated to be 6.5 days. Perfluorobutyl ethylene does not contain chromophores that absorb at wavelengths >290 nm, and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, perfluorobutyl ethylene is expected to be immobile based upon an estimated Koc of 7800. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 110 atm-cu m/mole. However, adsorption to soil is expected to attenuate volatilization. Perfluorobutyl ethylene may volatilize from dry soil surfaces based upon its vapor pressure. If released into water, perfluorobutyl ethylene is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Biodegradation data in soil and water were not available. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 4.9 hours and 6.2 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column; volatilization half-life from a model pond is estimated as 80 days when adsorption is considered. An estimated BCF of 370 suggests the potential for bioconcentration in aquatic organisms is high, provide

Regulation (EC) No 1935/2004 (amended)

1-Hexene, 3,3,4,4,5,5,6,6,6-nonafluoro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Hexene, 3,3,4,4,5,5,6,6,6-nonafluoro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 09-12-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/5646

1-Hexene, 3,3,4,4,5,5,6,6,6-nonafluoro-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Used as a solvent in the production of fluorine-containing polymers; [ACGIH]

PFBE is part of a solvent mixture or spin agent that has been used in the production of polymers containing fluorine.

2023: <75,000 lb；2022: <75,000 lb；2021: 75,000 - <500,000 lb；2020: <75,000 lb

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#7760]

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: 1-Hexene, 3,3,4,4,5,5,6,6,6-nonafluoro-. Aggregated National Production Volume: < 500,000 lbs.

Miscellaneous Manufacturing；All Other Basic Organic Chemical Manufacturing

1-Hexene, 3,3,4,4,5,5,6,6,6-nonafluoro-: ACTIVE