Aramite

Pesticide -> EPA IRIS

Insecticides

Active substance -> EU Pesticides database: Not approved

Pesticides -> Other Insecticides

1.143 at 20 °C/20 °C

DENSITY: 1.145-1.162 /TECHNICAL PRODUCT/

Colorless liquid

Clear light-colored oil

Practically insol in water; miscible with many organic solvents; solubility in petroleum oils decr rapidly with decr temperatures

> 10% in ethanol

> 10% in benzene

> 10% in acetone

For more Solubility (Complete) data for ARAMITE (7 total), please visit the HSDB record page.

175 °C at 0.1 mm Hg

BP: 195 °C at 2 mm Hg

Danger

H315 (92.9%): Causes skin irritation [Warning Skin corrosion/irritation]

P203, P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P318, P321, P332+P317, P337+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

H351: Suspected of causing cancer [Warning Carcinogenicity]

Hazard Traits - Carcinogenicity

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Aramite (140-57-8) is delisted as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/append/appb.pdf]

This product was voluntarily cancelled on the basis of oncogenicity according to US EPA in a notice dated April 12, 1977.

This rule revokes the tolerances established for residues of 20 pesticide chemicals /including aramite/ in or on certain raw agricultural commodities. This regulatory action is being taken by EPA to revoke tolerances for those pesticides which have no registered food uses or if they were registered the registrations were subsequently cancelled. 40 CFR Part 180 is amended: Section 180.107 is removed.

Skin Irrit. 2 (92.9%)

Carcinogenicity - Category 2

Acute toxicity (Oral) - Category 5

Carcinogens

This chemical is a combustible liquid. Poisonous gases including chlorine and sulfur oxide are produced in fire. Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. Containers may explode in fire. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped in OSHA 1910.156.

Store in tightly closed containers in a cool, well-ventilated area way from alkalis, nitrates, and heat. This material may be thermally unstable (Verschueren). Where possible, automatically transfer material from drums or other storage containers to process containers. Sources of ignition such as smoking and open flames are prohibited where this chemical is handled, used, or stored. Metal containers involving the transfer of 5 gallons or more of this chemical should be grounded and bonded. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment and fittings. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHA standard 1910.1045.

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Ventilate area of pill or leak. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or similar material and deposit in sealed containers. Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Mix aramite with excess CaO /calcium oxide/ or NaOH /sodium hydroxide/ and sand or other adsorbent in a pit or trench at least 0.5 m deep in a clay soil. NaOH (or Na2CO3) /sodium carbonate/ can also be added to the mixture to help speed the reactions when calcium oxide is used as the main alkali. The amt of calcium oxide or sodium hydroxide to use depends on the amt of pesticide to be disposed of and, to some extent, the concn of active ingredient in the pesticide and the actual chemical nature of the active ingredient. A practical guideline, in the absence of specific directions, is to use an approx vol or wt of alkali from one-half of to the same as that of the pesticide. For dilute formulations, such as a 1% soln or dust, the amt of calcium oxide or sodium hydroxide can be reduced by one-half. For very concn pesticides (over 80% active ingredient) the amt of calcium oxide or sodium hydroxide can be doubled, but the concn should be mixed first with water (or soapy water) before reaction with the alkali. For safety, a preliminary test should be made in which very small amt of the pesticide and alkali are mixed and observed briefly to make sure it does not react too vigorously. Sizeable quantities of pesticides can be disposed of in several smaller batches, rather than all at once, for added safety. Recommendable methods: Incineration, hydrolysis, landfill, & discharge to sewer. Peer review: Small amt when hydrolized can be flushed to sewer or landfilled. Large amt should be incinerated in a unit with effluent gas scrubbing. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for ARAMITE (9 total), please visit the HSDB record page.

PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Operations connected with synth & purification ... should be carried out under well-ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": Vertical laminar-flow biological safety cabinets may be used for containment of in vitro procedures ... provided that the exhaust air flow is sufficient to provide an inward air flow at the face opening of the cabinet, & contaminated air plenums that are under positive pressure are leak-tight. Horizontal laminar-flow hoods or safety cabinets, where filtered air is blown across the working area towards the operator, should never be used ... Each cabinet or fume cupboard to be used ... should be tested before work is begun (eg, with fume bomb) & label fixed to it, giving date of test & avg air-flow measured. This test should be repeated periodically & after any structural changes. /Chemical Carcinogens/

For more Preventive Measures (Complete) data for ARAMITE (10 total), please visit the HSDB record page.

Wear protective gloves and clothing to prevent any reasonable probability of skin contact. Wear splash-proof chemical goggles and face shield unless full face-piece respiratory protection is worn. Contact lenses should not be worn when working with this chemical. Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash.

PRECAUTIONS FOR "CARCINOGENS": ... Dispensers of liq detergent /should be available./ ... Safety pipettes should be used for all pipetting. ... In animal laboratory, personnel should ... wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. ... gowns ... /should be/ of distinctive color, this is a reminder that they are not to be worn outside the laboratory. /Chemical Carcinogens/

LC50 Coturnix japonica (Japanese quail, 14-day old) oral > 5000 ppm (5 day ad libitum diet)

EC50 Daphnia pulex (daphnids) 0.16 mg/L for 48 hr

LC50; Species: Colinus virginianus (Northern bobwhite, age 10 days) oral >5000 ppm/8 days

LC50; Species: Phasianus colchicus (Ring-necked pheasant, age 14 days) oral >5000 ppm/8 days

For more Ecotoxicity Values (Complete) data for ARAMITE (12 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2.0X10+4(SRC), determined from a structure estimation method(2), indicates that aramite is expected to be immobile in soil(SRC). Volatilization of aramite from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.9X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Aramite is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.2X10-7 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data for aramite are not available(SRC, 2007).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2.0X10+4(SRC), determined from a structure estimation method(2), indicates that aramite is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.9X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 1000(SRC), from an estimated log Kow of 4.8(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is very high(SRC). Biodegradation data for aramite are not available(SRC, 2007).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), aramite, which has an estimated vapor pressure of 2.2X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase aramite is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hours(SRC), calculated from its rate constant of 3.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase aramite may be removed from the air by wet or dry deposition(SRC). In hexane solution, aramite does not absorb UV irradiation above 290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(5).

Aramite

Hepatic

PRECAUTIONS FOR "CARCINOGENS": Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning ... /cytogenetic and/or other/ tests that might become useful or mandatory. /Chemical Carcinogens/

Using a structure estimation method based on molecular connectivity indices(1), the Koc of aramite can be estimated to be 2.0X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that aramite is expected to be immobile in soil.

Aramite

Group 2B: Possibly carcinogenic to humans

Volume 5: (1974) Some Organochlorine Pesticides

1987

1987

An estimated BCF of 1000 was calculated for aramite(SRC), using an estimated log Kow of 4.8(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC), provided the compound is not metabolized by the organism(SRC).

This product was voluntarily cancelled on the basis of oncogenicity according to US EPA in a notice dated April 12, 1977.

This rule revokes the tolerances established for residues of 20 pesticide chemicals /including aramite/ in or on certain raw agricultural commodities. This regulatory action is being taken by EPA to revoke tolerances for those pesticides which have no registered food uses or if they were registered the registrations were subsequently cancelled. 40 CFR Part 180 is amended: Section 180.107 is removed.

Used formerly as an antimicrobial agent, miticide, and acaricide; [HSDB]

Farming (Pesticides) [Category: Industry]

Antimicrobicide agent /Former/

Miticide /Former/

Used extensively as an acaricide on citrus /former use/

LIQ CONCENTRATE (90%), FOR PAINTING HOT WATER PIPES; EMULSIFIABLE LIQ (204 LB/US GALLON); DISPERSIBLE POWDERS (USUALLY 15%); DUSTS (USUALLY 3%).

ARAMITE WAS FORMERLY AVAILABLE IN US AS A TECHNICAL GRADE PRODUCT CONTAINING 90% ACTIVE INGREDIENT. IT WAS ALSO OFFERED FOR SALE AS AN 85% EMULSIFIABLE CONCENTRATE, AS A 15% WETTABLE POWDER ... .

TECHNICAL: ... AT LEAST 90% PURITY.

Food Contaminant -> CONTAMINANT -> JECFA Functional Classes

ACARICIDES

This product was voluntarily cancelled on the basis of oncogenicity according to US EPA in a notice dated April 12, 1977.

INCOMPATIBLE WITH ALKALINE MATERIALS SUCH AS LIME OR BORDEAUX MIXTURE.

ARAMITE /PRODUCTION/ DISCONTINUED BY UNIROYAL.

RESIDUAL ACTION EFFECTIVE FOR SOME 7 DAYS.

Prepn: Harris et al, US patent 2,529,494 (1950 to US Rubber).