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N-2-Hydroxyethylacetamid
Acetamide MEA · N-(2-HYDROXYETHYL)ACETAMIDE · N-ACETYLETHANOLAMINE · Amidex AME · Hetamide MA · Lipamide MEAA · Upamide ACMEA · Foamid AME-70
Identifikatoren & physikalische Daten
| CAS No. | 142-26-7 |
|---|---|
| Summenformel | C4H9NO2 |
| Durchschnittliche Molmasse | 103,12 g/mol |
| Monoisotopische Masse | 103,06332853 g/mol |
| SMILES | CC(=O)NCCO |
| InChIKey | PVCJKHHOXFKFRP-UHFFFAOYSA-N |
| PubChem CID | 8880 |
| ChEMBL | CHEMBL3188272 |
| ChEBI | CHEBI:74687 |
| EC No. | 205-530-8 |
| DTXSID | DTXSID6044804 |
| Lokaler Name | N-2-Hydroxyethylacetamid |
Chemische & physikalische Eigenschaften
| XLogP | -1,1 |
|---|---|
| Polarare Oberfläche (TPSA) | 49,3 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 7 |
| Formalladung | 0 |
| Komplexität | 62,7 |
| Stoffklassen | Nitrogen Compounds -> Ethanolamines |
| Kosmetika | Cosmetic ingredients (Acetamide MEA) -> CIR (Cosmetic Ingredient Review)HumectantAntistatic |
| SpringerMaterials Properties | Dielectric constant |
| Dichte | 1.1079 @ 25 °C/4 °C1.12 g/mL at 25 °C (lit.) |
| Color/Form | NEEDLES (ACETONE)BROWN, VISCOUS LIQUID |
| Löslichkeit | SOL IN ALL PROP IN WATERSOL IN HOT ACETONESLIGHTLY SOL IN BENZENE, PETROLEUM ETHERChloroform (Sparingly), Methanol (Slightly)Soluble in water, 1e+006 mg/L @ 25°C (est), soluble in alcohol and ether. |
| Flammpunkt | 176.6 °C350 °F OC |
| Siedepunkt | 166-167 °C @ 8 MM HG151-155 °C/5 mmHg (lit.) |
| Schmelzpunkt | 63-65 °C15.8 °C |
| Dampfdruck | 0.001 [mmHg]0.368-10.5Pa at 25-70℃ |
| Food Contact Substances | FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR |
| Brechungsindex | INDEX OF REFRACTION: 1.4674 @ 20 °C/Dn20/D 1.472(lit.) |
| Lagerbedingungen | Sealed in dry,Room Temperature |
| pKa (Säurekonstante) | 14.56±0.10(Predicted) |
| Aggregatzustand | Liquid |
| Farbe | Clear white to yellow |
| Kosmetik-Inhaltsstoffe Funktionen | SURFACTANT - CLEANSINGHAIR CONDITIONINGHUMECTANTSKIN CONDITIONINGSURFACTANT - FOAM BOOSTINGVISCOSITY CONTROLLING |
| InChI | 1S/C4H9NO2/c1-4(7)5-2-3-6/h6H,2-3H2,1H3,(H,5,7) |
| InChIKey | PVCJKHHOXFKFRP-UHFFFAOYSA-N |
| SMILES | CC(=O)NCCO |
| LogP (Verteilungskoeffizient) | -0.117 at 22.2℃ and pH5.4 |
| Oberflächenspannung | 72.1mN/m at 1g/L and 21.4℃ |
| CAS Datenbank | 142-26-7(CAS DataBase Reference) |
| NIST chemische Informationen | Acetamide, N-(2-hydroxyethyl)-(142-26-7) |
| EPA chemische Informationen | Acetamide, N-(2-hydroxyethyl)- (142-26-7) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 40% (32 of 80) of reports.DangerH315 (51.2%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 80 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Acetamide, N-(2-hydroxyethyl)-Acetamide, N-(2-hydroxyethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetamide, N-(2-hydroxyethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 08-10-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/24151Acetylethanolamine: Does not have an individual approval but may be used under an appropriate group standard |
| Brandpotenzial | SLIGHT, WHEN EXPOSED TO HEAT OR FLAME. |
| Gefahrenübersicht | Emergency treatment: EthanolamineEthanolamine can cause CNS depression, skin burns, and acute injury to the kidneys, liver, and lungs[HSDB] An irritantMay cause serious eye injury[MSDSonline] |
| NFPA Hazard Classification | 1 - Materials that, under emergency conditions, can cause significant irritation.1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.0 - Materials that in themselves are normally stable, even under fire conditions. |
| Hazard Classes and Categories | Skin Irrit. 2 (51.2%) |
| Brandbekämpfungsverfahren | WATER, FOAM, ALCOHOL FOAM, CARBON DIOXIDE, DRY CHEMICAL... |
| Lagerbedingungen | IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED... INCOMPATIBLE MATERIALS SHOULD BE ISOLATED FROM EACH OTHER. |
| Unerwünschte Wirkungen | Neurotoxin - Other CNS neurotoxin |
| Toxizitätsübersicht | The CIR Expert Panel concluded that the ethanolamides listed subsequently are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating. The Expert Panel cautioned that these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed...Acetamide MEASafe for use in cosmetics, with qualifications |
| Non-Human Toxicity Excerpts | HYDROXYETHYL ACETAMIDE RATED 3 ON RABBIT EYES. /TESTED EXTERNALLY ON EYES OF RABBITS & HAVE BEEN RATED NUMERICALLY ON SCALE OF 1 TO 10 ACCORDING TO DEGREE OF INJURY OBSERVED AFTER 24 HR, PAYING PARTICULAR ATTENTION TO CONDITION OF CORNEA. MOST SEVERE INJURIES HAVE BEEN RATED 10./WHEN INJECTED IV INTO RABBITS FOR 7 DAYS, N-ACETYLETHANOLAMINE (30-34 MG/G/DAY) DECR ASPARTATE LEVEL IN BRAIN & KIDNEY. ADMIN IN SINGLE INJECTION, N-ACETYLETHANOLAMINE INCR LEVELS OF GLUTAMATE, ASPARTATE, & GABA IN BRAIN.N-ACETYLETHANOLAMINE (42 MG/KG) GIVEN IP TO RATS INCR GLYCOGEN & ATP IN LIVER, KIDNEYS, BRAIN, & HEART. |
| Wassergefährdungsklasse (WGK) | 2 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29241990 |
| RTECS-Nr. | AC3120000 |
| R-Sätze (R) | 36/37/38-41-37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36 |
| Lagerklasse | 10 - Combustible liquids |
| Gefahrstoffdaten | 142-26-7(Hazardous Substances Data) |
| Gefahrenklasse | Eye Dam. 1Skin Irrit. 2STOT SE 3 |
Anwendungen & Verwendung
Verwenden
2-Acetylaminoethanol is a humectant recommended for use in emulsions.