HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Piperazindihydrochlorid
Piperazine 2HCl · PipDCl · dowzenedhc · dihydropipwormer · PIPERAZINE DI HCL · piperazinewormerpremix · Piperazine hydrate CRS · piperazinehydrochloride
Identifikatoren & physikalische Daten
| CAS No. | 142-64-3 |
|---|---|
| Summenformel | C4H12Cl2N2 |
| Durchschnittliche Molmasse | 159,05 g/mol |
| Monoisotopische Masse | 158,0377538 g/mol |
| SMILES | C1CNCCN1.Cl.Cl |
| InChIKey | CVVIJWRCGSYCMB-UHFFFAOYSA-N |
| PubChem CID | 8893 |
| ChEMBL | CHEMBL3188015 |
| EC No. | 205-551-2 |
| DTXSID | DTXSID4047096 |
| Lokaler Name | Piperazindihydrochlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 24,1 |
|---|---|
| H-Brücken-Donoren | 4 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 8 |
| Formalladung | 0 |
| Komplexität | 26 |
| Color/Form | CREAM COLORED CRYSTALLINE POWDERWHITE NEEDLESWhite to creamy colored needles or powder. |
| Löslichkeit | 41 % (NIOSH, 2024)SOLUBILITY IN WATER: 35% @ 0 °C, 41% @ 20 °C, 48% @ 50 °CINSOL IN ORGANIC SOLVENTS |
| Decomposition | When heated to decomposition it emits very toxic fumes of nitrous oxide and hydrogen chloride. |
| Schmelzpunkt | 635 °F (NIOSH, 2024)320°C(dec.)(lit.) |
| Physical Description | Piperazine dihydrochloride appears as white to cream-colored needles or powder. Mp: 318-20 °C (with decomposition).White to cream-colored needles or powder[NIOSH]White to cream-colored needles or powder. |
| Stability/Shelf Life | STABLE @ TEMP TO 270 °C & IN NEUTRAL OR ACID MEDIAStability of piperazine can be accomplished by use of its simple salts, /including hydrochloride/, which are more stable than the piperazine base. |
| Other Experimental Properties | SLIGHTLY HYGROSCOPIC82-83 °C /Monohydrate/ |
| Siedepunkt | 262.01°C (rough estimate) |
| Dichte | 1.3011 (rough estimate) |
| Brechungsindex | 1.6300 (estimate) |
| Lagerbedingungen | Inert atmosphere,Room Temperature |
| Aggregatzustand | White crystalline solid |
| Farbe | White to Off-White |
| Hauptanwendungen | pharmaceutical (small molecule) |
| InChI | InChI=1S/C4H10N2.2ClH/c1-2-6-4-3-5-1/h5-6H,1-4H22*1H |
| InChIKey | CVVIJWRCGSYCMB-UHFFFAOYSA-N |
| SMILES | C1NCCNC1.Cl.Cl |
| LogP (Verteilungskoeffizient) | -1.171 (est) |
| CAS Datenbank | 142-64-3(CAS DataBase Reference) |
| EPA chemische Informationen | Piperazine dihydrochloride (142-64-3) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH315: Causes skin irritation [Warning Skin corrosion/irritation]H317: May cause an allergic skin reaction [Warning Sensitization, Skin]H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]H361fd: Suspected of damaging fertilitySuspected of damaging the unborn child [Warning Reproductive toxicity]H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P203, P233, P260, P261, P264, P264+P265, P271, P272, P273, P280, P284, P302+P352, P304+P340, P305+P351+P338, P318, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement) |
|---|---|
| Regulatorische Informationen | Chemical: Piperazine, dihydrochlorideHazard Traits - Respiratory ToxicityAuthoritative List - EC Annex VI Resp. Sens. - Cat. 1Report - if used as a fragrance or flavor ingredientPiperazine dihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| Weitere Sicherheitsinformationen | IMAP assessments - Piperazine salts: Human health tier II assessment |
| Gesundheitsgefahren | Excerpt from NIOSH Pocket Guide for Piperazine dihydrochloride:Exposure Routes: Inhalation, skin absorption, ingestion, skin and/or eye contactSymptoms: Irritation eyes, skin, respiratory systemskin burns, sensitizationasthmagastrointestinal upset, headache, nausea, vomiting, incoordination, muscle weakTarget Organs: Eyes, skin, respiratory system, central nervous system (NIOSH, 2024) |
| Gefahrenübersicht | Piperazine dihydrochloride is well tolerated as an oral medication at a dose of 150 mg/kg for several days. Skin burns, allergic contact dermatitis, and asthma have been reported after occupational exposures to piperazine dust. [ACGIH] Piperazine, CAS # 110-85-0, is corrosive to skin. [Quick CPC] Asthma reported in pharmaceutical and chemical production workers |
Anwendungen & Verwendung
Verwenden
Piperazine Dihydrochloride is an anthelmintic agent used in the treatment of parasitic worms in animals.