Methylarsonsäure, Dinatrium-Salz

DSMA · dimet · sodar · somar · dinate · di-tac · dma100 · methar

Identifikatoren & physikalische Daten

CAS No.	144-21-8
Summenformel	CH3AsNa2O3
Durchschnittliche Molmasse	183,934 g/mol
Monoisotopische Masse	183,90935402 g/mol
SMILES	C[As](=O)([O-])[O-].[Na+].[Na+]
InChIKey	SDIXRDNYIMOKSG-UHFFFAOYSA-L
PubChem CID	8947
ChEMBL	CHEMBL2289061
EC No.	205-620-7
DTXSID	DTXSID4032665
Lokaler Name	Methylarsonsäure, Dinatrium-Salz

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)	63,2
H-Brücken-Donoren	0
H-Brücken-Akzeptoren	3
Frei drehbare Bindungen	0
Schwere Atome	7
Formalladung	0
Komplexität	49,8
Stoffklassen	Metals -> Arsenic Compounds, OrganicCarcinogens
LogP (Verteilungskoeffizient)	Kow = <10
Geschmack	Pleasant acid taste
Dichte	1.04 g/ml1.1500
Color/Form	Hydrated crystals containing 5H2O or 6H2OMonoclinic spear-shaped plates from absolute alcoholWhite crystalline solid
Löslichkeit	Soluble in methanolpractically insoluble in most organic solventsSoluble in water (300 g/l at 25 °C)In water, 4.32X10+5 mg/l @ 25 °CWater (Sparingly)
Corrosivity	NON-CORROSIVE TO IRON, RUBBER AND MOST PLASTICSMildly corrosive
Decomposition	When heated to decomposition it emits toxic fumes of /arsenic & sodium oxide/.DECOMPOSED BY STRONG OXIDIZING & REDUCING AGENTS.
Schmelzpunkt	>355 °CMelting point 132-139 °C /Disodium methanearsonate hexahydrate/
Dampfdruck	0.0000001 [mmHg]10-7 mm Hg @ 25 °C
Physical Description	Colorless hygroscopic solid[Hawley]
Stability/Shelf Life	DECOMPOSED BY STRONG OXIDIZING & REDUCING AGENTS./Decomposes/ slowly at elevated temperatures. Stable to hydrolysis.
Siedepunkt	165°C
Aggregatzustand	Solid
Farbe	White to Off-White
Stabilität	Hygroscopic
EPA chemische Informationen	Disodium methanearsonate (144-21-8)

Sicherheit & Vorschriften

GHS-Einstufung	DangerH301 (95%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatorische Informationen	Disodium methanearsonate is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)Restricted substance: Disodium methylarsonateThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
Weitere Sicherheitsinformationen	IMAP assessments - Arsonic acid, methyl-, disodium salt: Environment tier I assessment
Brandpotenzial	NOT FLAMMABLEDangerous fire hazard by spontaneous chemical reaction. Ignites spontaneously in dry air. Can react vigorously with oxidizing materialse.g. air, /chloride/.
Gefahrenübersicht	A mild skin and eye irritant[HSDB] May cause irritation[MSDSonline] Most excreted unchanged[Rosenstock, p. 947] For MSMA and DSMA, developmental studies of rats and rabbits along with a two-generation reproductive study show no indication of increased susceptibilityNo evidence of carcinogenicityTarget organs are large intestines and kidneys[Reference #1] See Dimethylarsenic acid.
FIFRA-Anforderungen	As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Disodium methanearsonate is found on List B. Case No: 2395Pesticide type: insecticide, herbicide, rodenticideCase Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.Active ingredient (AI): Disodium methanearsonateData Call-in (DCI) Date(s): 06/14/91, 03/03/95, 10/13/95AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.Tolerances are established for residues of the herbicide methanearsonic acid (calculated as As2O3) from application of the disodium and monosodium salts of methanearsonic acid in or on raw agricultural commodities as follows: citrus fruitcottonseedand cottonseed hulls.If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/
OSHA Standards	Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/
Luftstandards	Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Disodium methanearsonate is included on this list.(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/
EPA Hazardous Waste Number	D004A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/
Other Hazardous Reactions	Poisonous gases are produced when heated
Clean Water Act Anforderungen	Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic & cmpd/For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/l, 2.2 ng/l, & .22 ng/l, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/ml, 17.5 ng/l, & 1.75 ng/l, respectively. /Arsenic/D004A solid waste containing arsenic may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste.
Hazard Classes and Categories	Acute Tox. 3 (95%)Carcinogens
Standard Transportation Number	49 232 11Arsenical compound nos, solid, (or) arsenical mixture, NOS, solid49 232 10Arsenical cmpd, NOS, liquid (or) arsenical mixture, NOS, liquid
Brandbekämpfungsverfahren	Wear goggles and self contained breathing apparatusFire extinguishing media: Dry chemical, carbon dioxide.
Lagerbedingungen	Do not store near feed, food.
Entsorgungsverfahren	Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D004, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.Arsenic or organo-arsenic containing wastewater treatment sludges from production of veterinary pharmaceuticals are poor candidates for incineration.
Preventive Measures	SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.Protective clothing to prevent contact with skinchemical goggles.Avoid skin contact or breathing spray mist. ... Keep children, domestic animals off treated areas until material washes into soil.
Minimum Risk Level	Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)
Allowable Tolerances	Tolerances are established for residues of the herbicide methanearsonic acid (calculated as As2O3) from application of the disodium and monosodium salts of methanearsonic acid in or on raw agricultural commodities as follows: citrus fruit, 0.35 ppmcottonseed, 0.7 ppmand cottonseed hulls, 0.9 ppm.Tolerances for total residues of combined arsenic (calculated as As) in food are established as follows: (a) In edible tissues & in eggs of chickens & turkeys: 0.5 ppm in uncooked muscle tissue2 ppm in uncooked edible by-products& 0.5 ppm in eggs. (b) In edible tissues of swine: 2 ppm in uncooked liver & kidney0.5 ppm in uncooked muscle tissue & by-products other than liver & kidney. /Arsenic/
Permissible Exposure Limit (PEL)	0.5 [mg/m3], as As
Personal Protective Equipment (PPE)	Goggles or face shield, rubber or neoprene gloves, rubber apron.
Other Standards Regulations and Guidelines	... The following countries had adopted the ... TLV of 0.5 mg/cu m: Austria, Belgium, Finland, Japan, and Holland. Czechoslavakia, East Germany, Hungary and Poland ... USSR ... 0.3 mg/cu mRomania and Switzerland, 0.2 mg/cu mSweden 0.05 mg/cu mand Italy 0.25 mg/cu m. /Arsenic and sol cmpd/
Treatment	Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)
Gesundheitliche Auswirkungen	Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)
Ökotoxizitätswerte	LC50 BLUEGILL SUNFISH (LEPOMIS MACROCHIRUS) > 1000 PPM/48 HR/FRESH WATER /CONDITIONS OF BIOASSAY NOT SPECIFIED/
Umweltverhalten	... FOUND RAPID LOSS OF HERBICIDAL ACTIVITY FROM DSMA APPLIED TO BOSKET SILT LOAM. MOST MARKED REDUCTION IN TOXIC RESIDUES OCCURRED BETWEEN INITIAL PLANTING DATE AND 16-WEEK REPLANTING DATE.TERRESTRIAL FATE: Organoarsenicals, such as dimethylarsinic acid, methanearsonic acid, monosodium and disodium salts, and sodium cacodylate are adsorbed by clay soils. After rapid initial adsorption, changes occur which result in the redistribution of dimethylarsinic acid into a less soluble form associated with aluminium in the soil. Downward leaching of the methanearsonic acid salts has also been reported. The methanearsonic acid salts and dimethylarsinic acid are fixed by iron and aluminium in the soil, although not as strongly as inorganic arsenate.REACTION OF ... DSMA ... EXAMINED IN ... PLANTS ... SINGLE RADIOACTIVE CMPD ... FOUND /IN PURPLE NUTSEDGE (CYPERUS ROTUNDUS LEGUMINOSAE)/ IN HOT 80% ETHANOL EXTRACT. RF WAS 0.59 COMPARED TO 0.66 FOR STANDARD DSMA. CHEM ANALYSIS REVEALED THAT C-AS BOND REMAINED INTACT.
Expositionspfade	Oral (L2)inhalation (L2)dermal (L2)
Toxizitätsübersicht	Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)
Signs and Symptoms	Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1).
Soil Adsorption/Mobility	TYPE OF CLAY MINERAL MAY BE RESPONSIBLE FOR DIFFERENT FIXATION TENDENCIES ... KAOLINITE REMOVED MUCH MORE DSMA FROM SOLN THAN DID VERMICULITE. SMALLER SIZE FRACTIONS OF AUGUSTA SILT LOAM ... ABSORBED LARGER PERCENTAGES OF MAA /METHANEARSONIC ACID/ PRESENT IN SOLUTION.PHYTOTOXICITY IS ... AFFECTED BY LEACHING OF DSMA. IF ARSONATE IS APPLIED WITHIN 2 HR OF RAIN, LITTLE ABSORPTION WILL OCCUR AND LEACHING OF MAA /METHANEARSONIC ACID/ PROCEEDS.... FOUND NO LEACHING OF DSMA IN DECATUR CLAY LOAM, WHILE 52% ... RECOVERED IN THE TWENTY 1 IN INCREMENTS OF LEACHATE FROM NORFOLK LOAMY SAND. MOVEMENT THROUGH NORFOLK LOAMY SAND OCCURRED AS BAND OF HIGH FRONTAL CONCN WHICH ... DECREASED IN DIRECTION OF ZONE OF APPLICATION.
Human Toxicity Excerpts	COMPOUNDS INCLUDED METHANEARSONIC ACID & ITS SODIUM SALTS9/34 CASES SHOWED SYSTEMIC SYMPTOMS & REMAINDER HAD EYE & SKIN IRRITATION.ORGANIC ARSENICALS INCLUDE DISODIUM METHYLARSONATE ... AND AMINE METHYLARSONATE. TOXICITY OF THESE CMPD TO HUMANS IS CONSIDERABLY LESS THAN ... INORGANIC ARSENICALSHOWEVER THEY ARE HARMFUL IF INHALED, SWALLOWED, OR IF THEY COME IN CONTACT WITH EYES OR SKIN.Toxic by ingestion and inhalation.
Environmental Biodegradation	... NORFOLK LOAMY SAND SAMPLES (WITH AND WITHOUT ORGANIC MATTER ADDED) SHOWED INCREASED DSMA DECOMPOSITION RELATIVE TO SOIL ORGANIC MATTER. THIS SUGGESTS ADAPTATION OF MICROBIAL POPULATION TO METABOLIZE METHYL CARBON OF MAA /METHANEARSONIC ACID/.
Sediment/Soil Concentrations	The sorption of arsenic, phosphate, disodium methanearsonate, and the sodium salt of cacodylic acid by 16 Mississippi river alluvial flood plain soils is measured in a slurry experiment in which initial pH and molar solution concn for all four solutes are identical. Sorption of the two organoarsenical herbicides is strongly correlated with arsenate and phophate sorption, and sorption of all four species is strongly correlated with clay and iron oxide contents of the soils.
Carcinogen Classification	3, not classifiable as to its carcinogenicity to humans. (L135)
Landesrichtlinien für Trinkwasser	(AZ) ARIZONA 10 ug/L /Arsenic/(CT) CONNECTICUT 10 ug/l /Arsenic/
Federal Drinking Water Standards	10 ug/l /Arsenic/
UN-Transportnummer	2759
RTECS-Nr.	PA2275000
R-Sätze (R)	22-50/53-23/25
Gefahrensymbole	Xn,N,T
Sicherheitshinweise (S)	26-61-60-45-28-20/21
Gefahrenklasse	6.1(b)
Verpackungsgruppe	III
Gefahrstoffdaten	144-21-8(Hazardous Substances Data)

Anwendungen & Verwendung

Beschreibung

Das Dinatriumsalz der Methylarsinsäure bildet farblose, leicht wasserlösliche Kristalle. Diese sind an der Luft vollkommen beständig. Der Stoff wurde früher als Chemotherapeutikum gegen verschiedene Hautkrankheiten, Anämie und Tuberkulose verwendet. Das Mittel wurde bereits um 1930 vom Markt zurückgezogen und durch wirksamere und weniger toxische Stoffe ersetzt.

Verwenden

Methylarsonic acid is used as herbicide.