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HCID 8948Erstellt: 4. November 2026

Methylarsonsure

C07294 · methylarsonic · methyl-arsonicaci · methylarsinicacid · methylarsenicacid · methanearsonicacid · Methylarsonic acid · Methanearsonic acid

https://huagongshe.com/de/chemical/8948

Molekülstruktur von Methylarsonsure

Identifikatoren & physikalische Daten

CAS No.124-58-3
SummenformelCH3AsO(OH)2
Durchschnittliche Molmasse139,97 g/mol
Monoisotopische Masse139,945464 g/mol
SMILESC[As](=O)(O)O
InChIKeyQYPPRTNMGCREIM-UHFFFAOYSA-N
PubChem CID8948
ChEMBLCHEMBL1743208
ChEBICHEBI:29852
EC No.204-705-6
DTXSIDDTXSID4020903
Lokaler NameMethylarsonsure

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)57,5
H-Brücken-Donoren2
H-Brücken-Akzeptoren3
Frei drehbare Bindungen0
Schwere Atome5
Formalladung0
Komplexität61,3
StoffklassenMetals -> Arsenic Compounds, Organic
GeschmackPleasant acid taste
Color/FormMonoclinic, spear-shaped plates from absolute alcoholWhite, crystalline solidLEAVES FROM ALCOHOL
LöslichkeitSoluble in ethanolIn water, 2.56X10+5 mg/l @ 20 °C.Solubility in water: very good218.8g/L(25 ºC)
CorrosivityMildly corrosive
DecompositionWHEN HEATED TO DECOMPOSITION IT EMITS TOXIC FUMES OF /ARSENIC/.
Schmelzpunkt160.5 °C161 °C161°
Dampfdruck0.00162 [mmHg]<7.5X10-8 mm Hg @ 25 °C
Physical DescriptionWhite hygroscopic solid[ICSC]WHITE HYGROSCOPIC SOLID IN VARIOUS FORMS.
Stability/Shelf LifeSTABLE
Dissociation ConstantspKa1= 4.1pKa2= 9.02
Other Experimental PropertiesStrong dibasic acid.Water high in calcium, magnesium and iron may cause precipitationthese cations form insoluble methane arsonate salts.
Siedepunkt393.3±25.0 °C(Predicted)
Aggregatzustandsolid
pKa (Säurekonstante)pK1:3.41pK2:8.18 (18°C)
Hauptanwendungenfood and beverages
EPA chemische InformationenMethylarsonic acid (124-58-3)

Sicherheit & Vorschriften

GHS-EinstufungDangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatorische InformationenHazard Traits - CarcinogenicityCardiovascular ToxicityDermatotoxicityDevelopmental ToxicityNeurotoxicityOther Toxicological Hazard TraitsRespiratory ToxicityRestricted substance: Methylarsonic acid
BrandgefahrenNot combustible. Gives off irritating or toxic fumes (or gases) in a fire.
GefahrenübersichtOral LD50 (rat) = 961 mg/kg[Sax] A mild skin, eye, and respiratory tract irritantMay cause kidney and liver injury[ICSC] After ingestion of arsenic-rich wine, the majority of the arsenic was excreted in the urine in methylated form (methylarsonic acid & dimethylarsinic acid)Methylarsonic acid (MAA) fed to dairy cows in cottonseed ration had no apparent adverse effectsMAA was poorly absorbed and rapidly excreted in the urine[HSDB] Arsenic is a known teratogen, but the effects of organic arsenicals is less clear. MAA is not likely to be a reproductive hazard at levels currently found in the environment[REPROTOX] An irritant[MSDSonline]
EG-EinstufungSymbol: T, NR: 23/25-50/53S: (1/2)-20/21-28-45-60-61Note: A, 1
UN-EinstufungUN Hazard Class: 6.1UN Pack Group: I
Special ReportsREVIEW OF THE CHEMICAL, PHYSICAL, & BIOL PROPERTIES & METHODS OF ANALYSIS FOR MONOMETHYLARSONIC ACID, CACODYLIC ACID, & THEIR SODIUM SALTS.[DIETZ EA JR, MOORE LO

Anwendungen & Verwendung

Beschreibung

Salts of methanearsonic acid,CH3AsO(OH)2, especially the iron ammonium salt, Neoasozin, used as a fungicide in rice growing and the sodium, ammonium, and diethanolam monium salts used as herbicides in cotton growing.

Verwenden

Methylarsonic acid is used as herbicide.

MONOMETHYLARSONIC ACID, CACODYLIC ACID, AND THEIR SODIUM SALTS
ANAL METHODS PESTIC PLANT GROWTH REGUL 10: 385-401 (1978)]
FIFRA-AnforderungenIf material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/
OSHA StandardsPermissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/
LuftstandardsListed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Methanearsonic acid is included on this list.(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/
Chemical DangersDecomposes on heating. This produces toxic fumes of arsenic oxides (see ICSC 0378). The solution in water is a medium strong acid.
Packaging and LabellingDo not transport with food and feedstuffs. Marine pollutant.
EPA Hazardous Waste NumberD004A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/
BrandbekämpfungIn case of fire in the surroundings, use appropriate extinguishing media.
Erste-Hilfe-MaßnahmenFresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Refer for medical attention .
Sichere LagerungSeparated from strong bases and food and feedstuffs. Dry. Store in an area without drain or sewer access.
LagerbedingungenSOLID FORMULATIONS ARE SOMEWHAT HYGROSCOPIC & SHOULD BE STORED IN DRY PLACE.
EntsorgungsverfahrenAt the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Verschüttetes entsorgenPersonal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Eye PreventionWear safety goggles or eye protection in combination with breathing protection if powder.
Inhalation RiskA harmful concentration of airborne particles can be reached quickly when dispersed.
Skin PreventionProtective gloves.
Minimum Risk LevelAcute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)
Exposure PreventionPREVENT DISPERSION OF DUST! AVOID ALL CONTACT!
Allowable TolerancesTolerances for total residues of combined arsenic (calculated as As) in food are established as follows: (a) In edible tissues & in eggs of chickens & turkeys: 0.5 ppm in uncooked muscle tissue2 ppm in uncooked edible by-products& 0.5 ppm in eggs. (b) In edible tissues of swine: 2 ppm in uncooked liver & kidney0.5 ppm in uncooked muscle tissue & by-products other than liver & kidney. /Arsenic/
TreatmentArsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)
Gesundheitliche AuswirkungenArsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)
UmweltverhaltenEVOLUTION OF DIMETHYLARSINE & TRIMETHYLARSINE FROM GRASSES TREATED WITH SODIUM ARSENITE, METHYLARSONIC ACID, DIMETHYLARSINIC ACID, OR PHENYLARSONIC ACID CONFIRMED THE IDEA OF NATURAL BIOMETHYLATION.Strongly adsorbed to soilfixed by Fe and Al hydrous oxides in soil. Sorption increases as size of clay fraction decreases.DECR IN PHYTOTOXICITY IS A RESULT OF FIXATION...MAINLY BY IRON & ALUMINUM HYDROUS OXIDES IN THE SOIL.
LebensmitteluntersuchungswerteNINETEEN SAMPLES REPRESENTING 13 VARIETIES OF RED & WHITE DOMESTIC TABLE WINES WERE ANALYZED FOR ARSENITE, ARSENATE, METHYLARSONIC ACID & DIMETHYLARSINIC ACID. THE CONCN OF ARSENITE RANGED FROM LESS THAN 1 TO 420 PPB, & THE CONCN OF ARSENATE RANGED FROM 1 TO 110 PPB. METHYLARSONIC ACID WAS BELOW LIMIT OF DETECTION OF 1 PPB.
Unerwünschte WirkungenOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
ExpositionspfadeThe substance can be absorbed into the body by inhalation of its aerosol and by ingestion.Oral (L2)inhalation (L2)dermal (L2)
ToxizitätsübersichtArsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)
Signs and SymptomsCough. Sore throat.Redness.Abdominal pain. Diarrhoea. Vomiting.Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1).
ICSC Environmental DataThe substance is toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.
TSCA Test SubmissionsMethylarsenic acid was evaluated for clastogenicity in groups of 20 male Long-Evans rats injected intraperitoneally with total dose levels of 0 or 500 mg/kg bw, in three equal increments at 2 day intervals. Blood and bone marrow samples were obtained from each rat at 1 and 30 days after treatment, for determination of chromosomal abnormalities. The treatment increased the frequency of 1 type of chromosomal aberration (gap/break) in bone marrow cells obtained on day 1, indicating that the test compound was positive for clastogenicity in rats under the conditions of this assay. Positive control treatment with a single intraperitoneal injection of 0.3 mg/kg triethylenemelamine produced a significant increase in the frequency of chromosomal aberrations in bone marrow cells collected on day 1bone marrow cells collected from positive control rats on day 30 and blood cells collected on day 1 or 30 were similar to negative controls in frequency of chromosomal aberrations.
Human Toxicity ExcerptsSKIN IRRITATION OF THESE VARIOUS ARSENICALS VARY FROM VERY-MILD TO NONE, DEPENDING ON ACIDITY OR ALKALINITY OF EACH PREPN, & SKIN SENSITIVITY OF EXPOSED INDIVIDUAL. SYMPTOMS OF...SUBACUTE POISONING WITH ARSENICALS.../INCL METHANEARSONIC ACID/ SALTY TASTE, BURNING IN THROAT, & COLICKY PAINS IN STOMACH & INTESTINES. GARLICKY ODOR OF BREATH & SKIN IS FREQUENTLY PRESENT. SYMPTOMS OF ACUTE POISONING...HEADACHE, VOMITING, DIARRHEA, DIZZINESS, STUPOR, CONVULSIONS, GENERAL PARALYSIS, & DEATH.
Environmental BiodegradationTHE METABOLISM OF MAA TO INORGANIC ARSENIC IS THE MAIN MECHANISM OF HERBICIDE DEGRADATION... THE ASSOC OF HERBICIDAL BREAKDOWN WITH THE GENERAL MICROBIOLOGICAL ACTIVITY SUGGESTS THAT THE OXIDATION OF MAA /METHANEARSONIC ACID/ OCCURRED COINCIDENTALLY WITH THE METAB OF SOIL ORG MATTER. ON THE OTHER HAND, BOTH NORFOLK LOAMY SAND SAMPLES (WITH & WITHOUT ORGANIC MATTER ADDED) SHOWED AN INCREASED DSMA /DISODIUM SALT OF MAA/ DECOMPOSITION RELATIVE TO SOIL ORGANIC MATTER. THIS SUGGESTED AN ADAPTATION OF THE MICROBIAL POPULATION TO METABOLIZE THE METHYL CARBON OF MAA. /INVESTIGATORS/...EXAM THE DEGRADATION OF MSMA /MONOSODIUM SALT OF MAA/ ON 4 SOILS. THEY CONCLUDED THAT SOIL MICROORGANISMS APPEARED TO PLAY SOME ROLE IN THE DECOMPOSITION PROCESS. A FUNGUS, SEVERAL ACTINOMYCETES, & SEVERAL BACTERIA WERE ISOLATED USING SOIL ENRICHMENT TECHNIQUES. THE ORGANISMS DEGRADED 3, 13 OR 9, & 20% OF THE MSMA IN 11 DAYS, RESPECTIVELY. HOWEVER, IN THE ABSENCE OF AN ENERGY SOURCE, MICROBIAL METABOLISM OF THE ORGANIC ARSENICAL WAS NONEXISTENT. THE PRODUCTS OF METABOLISM WERE CARBON DIOXIDE & ARSENATE. NO ARSENITE COULD BE DETECTED.
Clean Water Act AnforderungenToxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic & cmpd/For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/l, 2.2 ng/l, & .22 ng/l, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/ml, 17.5 ng/l, & 1.75 ng/l, respectively. /Arsenic/D004A solid waste containing arsenic may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste.
Landesrichtlinien für Trinkwasser(AZ) ARIZONA 10 ug/L /Arsenic/(CT) CONNECTICUT 10 ug/l /Arsenic/
Federal Drinking Water Standards10 ug/l /Arsenic/
UN-Transportnummer2759
Toxizitätmouse,LD50,oral,1800mg/kg (1800mg/kg),Journal of Agricultural and Food Chemistry. Vol. 45, Pg. 449, 1997.
Gefahrenklasse6.1(b)
VerpackungsgruppeIII
Gefahrstoffdaten124-58-3(Hazardous Substances Data)