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HCID 8992Erstellt: 3. November 2026

Flumethiazid

Ademol · Routrax · Fludemil · NSC44626 · NSC-44626 · NSC 44626 · flumethiazide · Trifluoromethylthiazide

Identifikatoren & physikalische Daten

CAS No.	148-56-1
Summenformel	C8H6F3N3O4S2
Durchschnittliche Molmasse	329,3 g/mol
Monoisotopische Masse	328,97518251 g/mol
SMILES	NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NC=NS2(=O)=O
InChIKey	RGUQWGXAYZNLMI-UHFFFAOYSA-N
PubChem CID	8992
ChEMBL	CHEMBL2105128
ChEBI	CHEBI:135404
EC No.	205-717-4
DTXSID	DTXSID60163862
Lokaler Name	Flumethiazid

Chemische & physikalische Eigenschaften

XLogP	-0,2
Polarare Oberfläche (TPSA)	135
H-Brücken-Donoren	2
H-Brücken-Akzeptoren	9
Frei drehbare Bindungen	1
Schwere Atome	20
Formalladung	0
Komplexität	617
LogP (Verteilungskoeffizient)	0.32
Color/Form	CRYSTALS
Löslichkeit	SPARINGLY SOL IN WATER50 MG/ML IN BOILING WATER WITH DECOMPPRACTICALLY INSOL IN ETHYL ACETATE, METHYL ETHYL KETONE, BENZENE, TOLUENESOL IN METHANOL, ETHANOL, DIMETHYL FORMAMIDE1.05g/L(room temperature)
Other Experimental Properties	UNSTABLE IN ALKALINE SOLN, CONVERSION TO PRECURSOR ALPHA,ALPHA,ALPHA-TRIFLUORO-3-AMINO-4,6-DISULFAMOYLTOLUENEDECOMP @ 305.4-307.8 °C
Schmelzpunkt	306.6°C
Siedepunkt	560.0±60.0 °C(Predicted)
Dichte	1.6578 (estimate)
pKa (Säurekonstante)	pKa 6.3(H2O) (Uncertain)

Sicherheit & Vorschriften

Wechselwirkungen	TUBULAR TRANSPORT OF THIAZIDES MAY BE INHIBITED BY PROBENECID. /BENZOTHIADIAZIDES/USE OF ENTERIC-COATED COMBINATIONS OF POTASSIUM CHLORIDE & THIAZIDE HAS BEEN ASSOC WITH HIGH INCIDENCE OF ULCERATION OF DISTAL JEJUNUM OR ILEUM. IT IS PREFERABLE TO PRESCRIBE PALATABLE SOLN OF POTASSIUM CHLORIDE... /BENZOTHIADIAZIDES/...THIAZIDE DIURETICS HAVE BEEN PRESCRIBED IN COMBINATION WITH ALDOSTERONE ANTAGONIST OR OTHER POTASSIUM-SPARING DIURETIC IN ORDER TO OBTAIN ADDITIVE DIURETIC EFFECT WITH MAINTENANCE OF POTASSIUM BALANCE. /BENZOTHIADIAZIDES/
Human Toxicity Excerpts	CLINICAL TOXICITY IS RELATIVELY RARE & USUALLY RESULTS FROM UNEXPECTED HYPERSENSITIVITY. CASES HAVE BEEN REPORTED WITH PURPURA, DERMATITIS WITH PHOTOSENSITIVITY, DEPRESSION OF FORMED ELEMENTS OF BLOOD, & NECROTIZING VASCULITIS... /BENZOTHIADIAZIDES/PLASMA URIC ACID IS FREQUENTLY ELEVATED & IN SUSCEPTIBLE PT MAY BE ASSOCIATED WITH ATTACKS OF GOUT. ... MANY OBSERVERS HAVE NOTED CORRELATION WITH HYPOKALEMIA & ALKALOSIS. INCR CONCN OF BLOOD AMMONIA HAVE BEEN REPORTED. /BENZOTHIADIAZIDES/IN PT...WITH HYPERTENSIVE DISEASE & DECR RENAL RESERVE, MANIFESTATIONS OF RENAL INSUFFICIENCY MAY BE AGGRAVATED AFTER INTENSIVE OR PROLONGED COURSES OF THIAZIDES THAT LEAD TO EXCESSIVE DEPLETION OF FLUID & ELECTROLYTE. /BENZOTHIADIAZIDES/IN CIRRHOSIS OF LIVER, DETERIORATIONG OF MENTAL FUNCTION, INCL ONSET OF COMA, HAS BEEN ATTRIBUTED TO THIAZIDE THERAPY. ... CHOLESTATIC HEPATITIS HAS ALSO BEEN REPORTED. THIAZIDES MAY INDUCE HYPERGLYCEMIA & AGGRAVATE PREEXISTING DIABETES MELLITUS. /BENZOTHIADIAZIDES/
Gefahrstoffdaten	148-56-1(Hazardous Substances Data)

Identifikatoren & physikalische Daten

CAS No.

148-56-1

Summenformel

C8H6F3N3O4S2

Durchschnittliche Molmasse

329,3 g/mol

Monoisotopische Masse

328,97518251 g/mol

SMILES

NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NC=NS2(=O)=O

InChIKey

RGUQWGXAYZNLMI-UHFFFAOYSA-N

PubChem CID

8992

ChEMBL

CHEMBL2105128

ChEBI

CHEBI:135404

EC No.

205-717-4

DTXSID

DTXSID60163862

Lokaler Name

Flumethiazid

Chemische & physikalische Eigenschaften

XLogP

-0,2

Polarare Oberfläche (TPSA)

135

H-Brücken-Donoren

H-Brücken-Akzeptoren

Frei drehbare Bindungen

Schwere Atome

Formalladung

Komplexität

617

LogP (Verteilungskoeffizient)

0.32

Color/Form

CRYSTALS

Löslichkeit

SPARINGLY SOL IN WATER50 MG/ML IN BOILING WATER WITH DECOMPPRACTICALLY INSOL IN ETHYL ACETATE, METHYL ETHYL KETONE, BENZENE, TOLUENESOL IN METHANOL, ETHANOL, DIMETHYL FORMAMIDE1.05g/L(room temperature)

Other Experimental Properties

UNSTABLE IN ALKALINE SOLN, CONVERSION TO PRECURSOR ALPHA,ALPHA,ALPHA-TRIFLUORO-3-AMINO-4,6-DISULFAMOYLTOLUENEDECOMP @ 305.4-307.8 °C

Schmelzpunkt

306.6°C

Siedepunkt

560.0±60.0 °C(Predicted)

Dichte

1.6578 (estimate)

pKa (Säurekonstante)

pKa 6.3(H2O) (Uncertain)

Sicherheit & Vorschriften

Wechselwirkungen

TUBULAR TRANSPORT OF THIAZIDES MAY BE INHIBITED BY PROBENECID. /BENZOTHIADIAZIDES/USE OF ENTERIC-COATED COMBINATIONS OF POTASSIUM CHLORIDE & THIAZIDE HAS BEEN ASSOC WITH HIGH INCIDENCE OF ULCERATION OF DISTAL JEJUNUM OR ILEUM. IT IS PREFERABLE TO PRESCRIBE PALATABLE SOLN OF POTASSIUM CHLORIDE... /BENZOTHIADIAZIDES/...THIAZIDE DIURETICS HAVE BEEN PRESCRIBED IN COMBINATION WITH ALDOSTERONE ANTAGONIST OR OTHER POTASSIUM-SPARING DIURETIC IN ORDER TO OBTAIN ADDITIVE DIURETIC EFFECT WITH MAINTENANCE OF POTASSIUM BALANCE. /BENZOTHIADIAZIDES/

Human Toxicity Excerpts

CLINICAL TOXICITY IS RELATIVELY RARE & USUALLY RESULTS FROM UNEXPECTED HYPERSENSITIVITY. CASES HAVE BEEN REPORTED WITH PURPURA, DERMATITIS WITH PHOTOSENSITIVITY, DEPRESSION OF FORMED ELEMENTS OF BLOOD, & NECROTIZING VASCULITIS... /BENZOTHIADIAZIDES/PLASMA URIC ACID IS FREQUENTLY ELEVATED & IN SUSCEPTIBLE PT MAY BE ASSOCIATED WITH ATTACKS OF GOUT. ... MANY OBSERVERS HAVE NOTED CORRELATION WITH HYPOKALEMIA & ALKALOSIS. INCR CONCN OF BLOOD AMMONIA HAVE BEEN REPORTED. /BENZOTHIADIAZIDES/IN PT...WITH HYPERTENSIVE DISEASE & DECR RENAL RESERVE, MANIFESTATIONS OF RENAL INSUFFICIENCY MAY BE AGGRAVATED AFTER INTENSIVE OR PROLONGED COURSES OF THIAZIDES THAT LEAD TO EXCESSIVE DEPLETION OF FLUID & ELECTROLYTE. /BENZOTHIADIAZIDES/IN CIRRHOSIS OF LIVER, DETERIORATIONG OF MENTAL FUNCTION, INCL ONSET OF COMA, HAS BEEN ATTRIBUTED TO THIAZIDE THERAPY. ... CHOLESTATIC HEPATITIS HAS ALSO BEEN REPORTED. THIAZIDES MAY INDUCE HYPERGLYCEMIA & AGGRAVATE PREEXISTING DIABETES MELLITUS. /BENZOTHIADIAZIDES/

Gefahrstoffdaten

148-56-1(Hazardous Substances Data)