N1-Methyl-Pseudouridine-5'-Triphosphate
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Grundinformationen
- CAS
1428903-59-6- Standard-SMILES
Cn1cc([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O- InChIKey
OLRONOIBERDKRE-CAYFCZNJNA-N- Summenformel
- C10H17N2O15P3
- Durchschnittliche Molmasse
- 498,17 g/mol
Namen und Bezeichner
- Bevorzugter Name
- N1-Methyl-Pseudouridine-5'-Triphosphate
- Englischer Name
- N1-Methyl-Pseudouridine-5'-Triphosphate
- Summenformel
- C10H17N2O15P3
- Molmasse
- 498.17
Namen und Synonyme
N1-Methylpseudouridine-5'-triphosphate1-Methylpseudouridine-5'-Triphosphate Trisodium saltabs60156N1-Me-pUTPN1-Me-ΨUTPPseudo-UTP-Na3N1 -Me-Pseudo UTPN1-Methylpseudo-UTPN1-Methy-Pseudo-UTPCytidine Impurity 9
Datenbank-Bezeichner
- CAS
1428903-59-6- PubChem CID
- 90456815
- UNII
- 5ENC36P33M
Eigenschaften
Physikochemische Eigenschaften
- Dichte
- 2.01 · 2.010±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C, · -20°C, sealed storage, away from moisture
- Aggregatzustand
- Liquid
- pka
- 0.97 · 0.97±0.50(Predicted)
- Farbe
- Colorless to light yellow
- PH
- 7 · 7.0 ± 0.1
- InChIKey
- OLRONOIBERDKRE-CAYFCZNJNA-N
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1C1=CN(C)C(=O)NC1=O)O |&1:1,2,3,19,r|
Chemie und Industrie
Anwendungen
BeschreibungN1-Methyl-Pseudouridine-5'-Triphosphate, also known as N1-Methylpseudouridine-5'-Triphosphate, N1meΨTP, m1ΨTP, or 1-Methyl-PseudoUridine Phosphoramidite, is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-Methylpseudouridine can reduce the immunogenicity of the resulting mRNA. In addition, the free form of the compound is prone to instability; it is advisable to consider the stable salt form (N1-Methylpseudouridine-5′-triphosphate trisodium) that retains the same biological activity.
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