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HCID 90478641Erstellt: 3. November 2026
Telomycin
A-128 · Nsc235069 · Telomycin · Antibiotic 128 · A 128-HYP, A 128-OP · 18H-Dipyrrolo[2,1-C:2',1'-o][1,4,7,10,13,16,19,22,25]oxaoctaazacyclooctacosine · N-(L-βAsp-L-Ser-)Cyclo(L-Thr*-L-aThr-L-Ala-Gly-L-t3Hyp-3-(1H-indole-3-yl)Dha-β-methyl-L-Trp-4,4-dimethyl-L-aThr-L-c3Hyp-) · L-Proline, L-β-aspartyl-L-seryl-L-threonyl-L-allothreonyl-L-alanylglycyl-(3S)-3-hydroxy-L-prolyl-α,β-didehydrotryptophyl-β-methyl-L-tryptophyl-(3S)-3-hydroxy-L-leucyl-3-hydroxy-, (11→3)-lactone, (3R)-
https://huagongshe.com/de/chemical/90478641
Identifikatoren & physikalische Daten
| CAS No. | 19246-24-3 |
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| Summenformel | C59H77N13O19 |
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| Durchschnittliche Molmasse | 1.272,3 g/mol |
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| Monoisotopische Masse | 1.271,54586728 g/mol |
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| SMILES | CC(c1c[nH]c2ccccc12)[C@@H]1NC(=O)C(=Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)CNC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)C[C@H](N)C(=O)O)[C@@H](C)OC(=O)[C@@H]2[C@H](O)CCN2C(=O)[C@H]([C@@H](O)C(C)C)NC1=O |
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| InChIKey | FJEKCPBQVANMTA-GRZFNQFESA-N |
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| PubChem CID | 90478641 |
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| EC No. | 242-913-9 |
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| Lokaler Name | Telomycin |
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Chemische & physikalische Eigenschaften
| XLogP | -3,7 |
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| Polarare Oberfläche (TPSA) | 496 |
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| H-Brücken-Donoren | 17 |
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| H-Brücken-Akzeptoren | 20 |
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| Frei drehbare Bindungen | 13 |
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| Schwere Atome | 91 |
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| Formalladung | 0 |
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| Komplexität | 2.760 |
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| Siedepunkt | 850.94°C (rough estimate) |
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| Dichte | 1.1263 (rough estimate) |
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| Brechungsindex | 1.6700 (estimate) |
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| Lagerbedingungen | Store at -20°C |
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| Löslichkeit | DMF: solubleDMSO: solubleEthanol: solubleMethanol: solubleWater: slightly soluble |
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| Aggregatzustand | A solid |
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| pKa (Säurekonstante) | 2.41±0.10(Predicted) |
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Sicherheit & Vorschriften
| Toxizität | LD50 in mice (mg/kg): >1000 orally, i.v., i.p., i.m. (Tisch) |
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Anwendungen & Verwendung
Verwenden
Telomycin is a complex, high molecular weight depsipeptide discovered in 1958. The structure was subsequently solved in 1968. Telomycin possesses potent and highly selective activity against Gram positive bacteria in vitro and in vivo when given by intramuscular administration. Telomycin is poorly absorbed after oral administration. Despite its structural novelty, telomycin has received little attention.