Mercaptaminhydrochlorid
Cysteamine Hydrochloride
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Grundinformationen
- CAS
156-57-0- Standard-SMILES
Cl.NCCS- InChIKey
OGMADIBCHLQMIP-UHFFFAOYSA-N- Summenformel
- C2H7NS.ClH
- Durchschnittliche Molmasse
- 113,61 g/mol
- Monoisotopische Masse
- 113,00659794
Überblick
Cysteamine hydrochloride is an alkanethiol.
Namen und Bezeichner
- Bevorzugter Name
- Cysteamine Hydrochloride
- IUPAC
- 2-aminoethanethiol;hydrochloride
- Lokaler Name
- Mercaptaminhydrochlorid
- Englischer Name
- Cysteamine hydrochloride
- Summenformel
- C2H8ClNS
- Molmasse
- 113.61
Namen und Synonyme
Cysteamine hydrochloride156-57-02-Aminoethanethiol hydrochlorideCysteamine HClMercaptamine hydrochlorideCysteaminium chlorideBekaptanETHANETHIOL, 2-AMINO-, HYDROCHLORIDEMercaptoethylamine hydrochlorideMerkamin hydrochlorideMercamine hydrochlorideCysteamine chlorohydrate
Weitere Namen anzeigen
2-MERCAPTOETHYLAMINE HYDROCHLORIDE2-AMINOETHANE-1-THIOL HYDROCHLORIDEAminoethanethiol hydrochloridemercaptoethylammonium chloride2-Mercaptoethylammonium chlorideL-Cysteamine hydrochloride2-AMINOETHANETHIOL HCL
CysteaminhydrochloridCystaranDTXSID8045779IF1B771SVBNSC-758692CI-9148CYSTADROPSNSC-21116
Datenbank-Bezeichner
- CAS
156-57-0、16904-32-8- PubChem CID
- 9082
- DTXSID
DTXSID8045779- ChEMBL
CHEMBL1256137- ChEBI
CHEBI:201814- UNII
- IF1B771SVB
- EC Number
- 205-858-1
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- Polarare Oberfläche (TPSA)
- 27 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 5
- Formalladung
- 0
- Komplexität
- 10
Experimentelle und physikochemische Eigenschaften
Chemical ClassesBiological Agents -> Amino Acids and Derivatives
CosmeticsReducing; Antioxidant
Solubility>17 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
EMA approved medicines: Human medicine (Orphan designations)
FDA approved drugs -> Active ingredient
Physical DescriptionSolid; [Merck Index] White hygroscopic crystals; [Alfa Aesar MSDS]
Physikochemische Eigenschaften
- Schmelzpunkt
- 67 · 67-71 °C
- Siedepunkt
- 238.5 ℃[at · 238.5℃[at 101 325 Pa]
- Dichte
- 0.75 · 0.75
- Dampfdruck
- 5.333 Pa · 5.333Pa at 25℃
- Brechungsindex
- 1.61 · 1.6100 (estimate)
- storage temp.
- 2 · 2-8°C
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 6.1% (17 of 278) of reports.
Warning
H302 (92.1%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 278 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Chemical: Ethanethiol, 2-amino-, hydrochloride
Status: Active Update: 28-01-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25700
Ethanethiol, 2-amino-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
Causes burns to skin and eyes; A respiratory tract irritant; [ECHA REACH Registrations] Teratogenicity observed in oral study of rats in the absence of maternal toxicity; Developmental toxicity observed in intraperitoneal study of mice; [Shepard's Catalog of Teratogenic Agents] A skin and strong eye irritant; Harmful by ingestion; [Alfa Aesar MSDS]
Hazard Classes and CategoriesAcute Tox. 4 (92.1%)
Toxikologische Informationen
Adverse EffectsDermatotoxin - Skin burns.
Sicherheitsdaten
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
CYSTEAMINE HYDROCHLORIDE
Cystine Disulfide Reduction [MoA]; Cystine Depleting Agent [EPC]
MeSH Pharmacological ClassificationCompounds and drugs that react with CYSTINE and convert it into a compound that can be more easily metabolized or intracellularly transported. Drugs in this class have been used to treat CYSTINOSIS.
Verwendung und Herstellung
Uses
Cysteamine is a natural antioxidant, precursor in taurine biosynthesis, and component of coenzyme A; Used in medical research (potent ulcerogen), as a drug (nephropathic cystinosis), and antidote (acetaminophen poisoning); [Merck Index] A radiation-protective agent that oxidizes in air to form CYSTAMINE. It can be given intravenously or orally to treat radiation sickness. The bitartrate has been used for the oral treatment of nephropathic cystinosis. [ChemIDplus] Used as an intermediate; [ECHA REACH Registrations]
Use ClassificationCosmetics -> Reducing; Antioxidant
General Manufacturing InformationEthanethiol, 2-amino-, hydrochloride (1:1): ACTIVE
Anwendungen
BeschreibungCysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.
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