Prednison-21-acetat

Prednisone acetate

HCID 91438CAS 125-10-0

Grundinformationen

Standard-SMILES
CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3C(=O)C[C@@]21C
InChIKey
MOVRKLZUVNCBIP-RFZYENFJSA-N
Summenformel
C23H28O6
Durchschnittliche Molmasse
400,5 g/mol
Monoisotopische Masse
400,18858862

Überblick

Cortancyl is a tertiary alpha-hydroxy ketone, a 17alpha-hydroxy steroid, a 20-oxo steroid, an acetate ester, an 11-oxo steroid, a steroid ester and a 3-oxo-Delta(1),Delta(4)-steroid. It is functionally related to a prednisone.

Namen und Bezeichner

Bevorzugter Name
Prednisone acetate
IUPAC
[2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Lokaler Name
Prednison-21-acetat
Englischer Name
Prednisone 21-acetate
Summenformel
C23H28O6
Molmasse
400.46

Namen und Synonyme

Prednisone acetatePrednisone 21-acetate125-10-0Cortancyldelta1-Cortisone-21-acetatedelta'-Dehydrocortisone acetateprednisone-21-acetateOU93QEL83U21-Acetoxy-17alpha-hydroxypregna-1,4-diene-3,11,20-trioneNSC-109651,4-Pregnadien-17alpha,21-diol-3,11,20-trione-21-acetateCHEBI:34655
Weitere Namen anzeigen
Prendnisone acetateFerrCblconind-CorlindeltalonePrednisone 21-acetat
DTXSID20154539RefChem:868422DTXCID3077030204-726-0DelcortinNisonedelta-corlinPregna-1,4-diene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-

Datenbank-Bezeichner

CAS
125-10-0
PubChem CID
91438
DTXSID
DTXSID20154539
ChEMBL
CHEMBL1507567
ChEBI
CHEBI:34655
UNII
OU93QEL83U
EC Number
204-726-0
Nikkaji
J86.135I

Eigenschaften

Berechnete Struktureigenschaften

XLogP
1,5
Polarare Oberfläche (TPSA)
97,7 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
6
Frei drehbare Bindungen
4
Schwere Atome
29

Experimentelle und physikochemische Eigenschaften

Endocrine DisruptorsPotential endocrine disrupting compound

Physikochemische Eigenschaften

Schmelzpunkt
240 · 240-242°C (dec.)
Siedepunkt
582 · 582.0±50.0 °C(Predicted)
Dichte
1.28 · 1.28±0.1 g/cm3(Predicted)
storage temp.
Refrigerator
Löslichkeit
Chloroform (Slightly), Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H302 (16.7%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P304+P340, P305+P351+P338, P318, P319, P330, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 6 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory InformationStatus: Active Update: 14-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/22156
Other Safety InformationIMAP assessments - Pregna-1,4-diene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-: Environment tier I assessment
Hazard Classes and CategoriesEye Irrit. 2 (16.7%)

Sicherheitsdaten

Alarmwort
Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H361

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 3 Einträge

Substances that reduce or suppress INFLAMMATION.

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)

Anwendungen

VerwendenAdrenocortical steroid antiinflammatory.

Vor- und nachgelagerte Produkte

Anbieter50 Anbieter

成都埃法生物科技有限公司028-028-85142057 19983342022 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
Hong Kong Tiansheng New Material Trading Co., Ltd+8617320695765 · [email protected]
湖北金梭生物科技有限公司00123456789 · [email protected]
Hebei shuoxi biotechnology co. LTD+8613081092107

Zugehörige Reaktionen

1

Verknüpfte Notizen

Wird geladen…