519-02-8O=C1CCC[C@@H]2[C@H]3CCCN4CCC[C@@H](CN12)[C@@H]34ZSBXGIUJOOQZMP-JLNYLFASSA-NMatrine is an alkaloid.
519-02-8DTXSID00274188Agrochemicals -> Pesticide active substances
Active substance -> EU Pesticides database: Not approved
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Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)
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The nervous system is the main target organ by the toxicity of matrine. Morphological observation revealed degenerative changes of the nerve cells in the brain tissue of the mice. (A15436) Matrine has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and µ-receptor agonist. Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities. (Wikipedia)
BeschreibungMatrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens Aiton. The extraction process involves the use of organic solvents on dry roots, plants, and fruits of kushen Sophora flavescens Ait. Matrine is also present in S. alopecuroides L. and S. subprostrata Chun et T. Chen.Chinese medicine Radix Sophora flavescentis have dampness eliminating insecticide and diuretic "Southern Yunnan Materia Medica" also recorded the effects of Saphora. flavescens.Sophora flavescens is a species of Sophora japonica and is distributed in temperate and subtropical regions. Sophora flavescens is widely distributed in China, mainly in the north of Hebei, the west of Henan, and southwest of Shandong, Anhui, Hubei, and Guizhou.
HistoryAs early as the 1930s, the Soviet Union began to study Sophora flavescens, and the china research began in 1972. Sophora flavescens in the chemical composition are divided into two major categories of alkaloids and flavonoids. Global research efforts are currently concentrated on studying alkaloids. So far, there are 23 species of alkaloids isolated and identified in roots, stems, leaves, and flowers of Sophora flavescens. The main components of Sophora flavescens have obvious anti-cancer effects, and oxymatrine has anti-cancer and antiaging effects.
Verwenden(+)-Matrine is an alkaloid compound extracted from the roots of Sophora species which maintain anti-inflammatory, anti-cancer and a host of other positive pharmacological effects. Apoptotic agent.
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CHEMBL204860CHEBI:6700DefinitionChEBI: Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and μ-receptor agonist.