Grundinformationen
- CAS
8047-67-4- Standard-SMILES
O.O.O.OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O.[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Na+].[Na+].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[OH-]- InChIKey
ADQSUDSYBZBMFT-JMMWHMDLNA-H- Summenformel
- C12H29Fe5Na2O23
- Durchschnittliche Molmasse
- 866,5 g/mol
- Monoisotopische Masse
- 866,76418
Überblick
Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, iron sucrose is more preferred in chronic kidney disease patients.
Namen und Bezeichner
- Bevorzugter Name
- Succharated ferric oxide
- IUPAC
- disodium;(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;pentakis(iron(3+));octakis(oxygen(2-));hydroxide;trihydrate
- Lokaler Name
- Eisensaccharat
- Englischer Name
- Iron saccharate
- Summenformel
- C18H24Fe2O24
- Molmasse
- 736.06
Namen und Synonyme
Succharated ferric oxideRefChem:1099121Sucroferric oxyhydroxideFerriveninFeojectinVenoferrumEnciferFerijetHippironProferrinSucroferVelphoro
Weitere Namen anzeigen
VenoferIronSucroseIron sucrose liquidIRON (III) OXIDE, SACCHARATEDXI 921
IvironFesinFerum HausmannFerrum VitisNeo-ferrumFerosoft SFe-backFerplex SS
Datenbank-Bezeichner
- CAS
8047-67-4- PubChem CID
- 91663255
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 202 Ų
- H-Brücken-Donoren
- 12
- H-Brücken-Akzeptoren
- 23
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 42
- Formalladung
- 0
- Komplexität
- 395
Experimentelle und physikochemische Eigenschaften
Human Drugs
Breast Feeding; Lactation; Milk, Human; Ferric Compounds; Hematinics; Iron Compounds
Breast Feeding; Lactation; Milk, Human; Ferric Compounds; Iron Compounds
EMA approved medicines: Human medicine
Physikochemische Eigenschaften
- Schmelzpunkt
- 168 · 168-171°C
- storage temp.
- Refrigerator
- Löslichkeit
- Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Brown to Dark Brown
- InChI
- InChI=1/3C6H10O8.2Fe/c3*7-1(3(9)5(11)12)2(8)4(10)6(13)14;;/h3*1-4,7-10H,(H,11,12)(H,13,14);;/q;;;2*+3/p-6/t3*1-,2-,3-,4+;;/s3
- InChIKey
- ADQSUDSYBZBMFT-JMMWHMDLNA-H
- CAS Datenbank
- 8047 · 8047-67-4(CAS DataBase Reference)
- EPA chemische Informationen
- Iron saccharate (8047-67-4)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Toxikologische Informationen
Effects During Pregnancy and Lactation
◉ Summary of Use during Lactation
◉ Summary of Use during Lactation
Sicherheitsdaten
- hs_code
- 29400090
- Toxizität
- LD50 in mice (mg Fe/kg): >2500 orally; >200 i.v. (Geisser)
Chemie und Industrie
Pharmakologische Informationen
ATC Code
V - Various
QV - Various
Protein BindingIt binds with transferrin.
PharmacodynamicsSignificant increases in serum iron and serum ferritin and significant decreases in total iron binding capacity occurred four weeks from the initiation of iron sucrose treatment.
Mechanism of Action
Following intravenous administration, iron sucrose is dissociated into iron and sucrose and the iron is transported as a complex with transferrin to target cells including erythroid precursor cells. The iron is then incorporated into hemoglobin as the cells mature into red blood cells.
Biological Half-Life6 hours.
Metabolism/MetabolitesFollowing IV administration, dissociated into iron and sucrose by the reticuloendothelial system.
FDA Pharmacological Classification
SUCROFERRIC OXYHYDROXIDE
Phosphate Binder [EPC]; Phosphate Chelating Activity [MoA]
Absorption, Distribution and Excretion
The intravensously administered iron sucrose injection would result rapidly in high serum iron levels. Maximum measured levels occured after 10 min of injection with an average of 30.00 mg/l.
Renal elimination of iron contributed very little to the total elimination (in average less than 5%). While, renal elimination of sucrose accounts for 68-75% of the administered dose after 4 and 24 hours respectively.
Vd is 7.3 L
Total body clearance is 20.5 ml/min.
Verwendung und Herstellung
Household ProductsInformation on 2 consumer products that contain Succharated ferric oxide in the following categories is provided:
Anwendungen
VerwendenIron Saccharate has been used to treat iron deficiency and iron deficiency anemia associated with different chronic diseases.
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