Technetium TC 99M trofolastat chloride
Grundinformationen
- CAS
1333117-95-5- Standard-SMILES
O=C([O-])CC[C@H](NC(=O)N[C@@H](CCC(=O)N[C@@H](CCCCN(Cc1nccn1CC(=O)N(CC(=O)[O-])CC(=O)[O-])Cc1nccn1CC(=O)N(CC(=O)[O-])CC(=O)[O-])C(=O)[O-])C(=O)[O-])C(=O)[O-].[99Tc+4].[C-]#[O+].[C-]#[O+].[C-]#[O+].[Cl-].[H+].[H+].[H+].[H+].[H+]- InChIKey
CGNYNFBQXMPHBV-LCERUKBVSA-J- Summenformel
- C40H47ClN10O23Tc
- Durchschnittliche Molmasse
- 1.170,2 g/mol
- Monoisotopische Masse
- 1.169,156655
Überblick
Technetium Tc-99M Trofolastat Chloride is the chloride salt form of a radioconjugate composed of an urea-based human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the gamma-emitting radioisotope technetium Tc 99m, with potential use as a tracer for PSMA-expressing tumors using single photon emission computed tomography/computed tomography (SPECT/CT). Upon intravenous administration of the technetium Tc 99m trofolastat, the trofolastat moiety targets and binds to PSMA-expressing tumor cells. Upon internalization, PSMA-expressing tumor cells can be detected during SPECT/CT imaging. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.
Namen und Bezeichner
- Bevorzugter Name
- Technetium TC 99M trofolastat chloride
- IUPAC
- (2S)-2-[[(1S)-4-[[(1S)-5-[bis[[1-[2-[bis(carboxylatomethyl)amino]-2-oxoethyl]imidazol-2-yl]methyl]amino]-1-carboxylatopentyl]amino]-1-carboxylato-4-oxobutyl]carbamoylamino]pentanedioate;carbon monoxide;hydron;technetium-99(4+);chloride
Namen und Synonyme
45WAL7ZXQTMIP-99mTc-1404Technetium Tc-99m trofolastatTechnetium tc 99m trofolastat chlorideTechnetium tc-99m trofolastat chlorideTechnetium (99mTc) trofolastat chloridetechnetium (mTc) trofolastat chloride [INN]F-1311TECHNETIUM TC 99M TROFOLASTAT CHLORIDE [USAN]TECHNETIUM (99MTC) TROFOLASTAT CHLORIDE [WHO-DD](OC-6-33)-TRICARBONYL(N2-(((1S)-1,3-DICARBOXYPROPYL)CARBAMOYL)-L-.GAMMA.-GLUTAMYL-N6,N6-BIS((1-(2-(BIS(CARBOXYMETHYL)AMINO)-2-OXOETHYL)-1H-IMIDAZOL-2-YL-.KAPPA.N3)METHYL)-L-LYSINE-.KAPPA.N6)(99MTC)TECHNETIUM(+) CHLORIDE
Datenbank-Bezeichner
- CAS
1333117-95-5、1333204-77-5- PubChem CID
- 91667764
- ChEMBL
CHEMBL4297855- UNII
- 45WAL7ZXQT
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 474 Ų
- H-Brücken-Donoren
- 8
- H-Brücken-Akzeptoren
- 27
- Frei drehbare Bindungen
- 25
- Schwere Atome
- 75
- Formalladung
- 0
- Komplexität
- 1.690
Chemie und Industrie
Pharmakologische Informationen
ATC Code
V - Various
QV - Various
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…