Pyridostigminbromid
Pyridinium, 3-hydroxy-1-methyl-, bromide, dimethylcarbamate
Grundinformationen
- CAS
101-26-8- Standard-SMILES
CN(C)C(=O)Oc1ccc[n+](C)c1.[Br-]- InChIKey
VNYBTNPBYXSMOO-UHFFFAOYSA-M- Summenformel
- C9H13BrN2O2
- Durchschnittliche Molmasse
- 261,12 g/mol
- Monoisotopische Masse
- 260,01604
Überblick
See also: Pyridostigmine Bromide (preferred); Pyridostigmine (has active moiety).
Namen und Bezeichner
- Bevorzugter Name
- Pyridinium, 3-hydroxy-1-methyl-, bromide, dimethylcarbamate
- IUPAC
- (1-methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate bromide
- Lokaler Name
- Pyridostigminbromid
- Englischer Name
- Mestinon
- Summenformel
- C9H13BrN2O2
- Molmasse
- 261.12
Namen und Synonyme
Dimethylcarbamic acid ester of 3-hydroxy-1-methylpyridinium bromideCarbamic acid, dimethyl-, ester with 3-hydroxy-1-methylpyridinium bromideRGVNPYSNWCWTBT-UHFFFAOYSA-NPyridinium, 3-hydroxy-1-methyl-, bromide, dimethylcarbamatePYRIDOSTIGMINE BROMIDEPYBR3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDEkalyminregonalkaliminro1-5130mestinon
Weitere Namen anzeigen
3-Hydroxy-1-mestinonbromide
Datenbank-Bezeichner
- CAS
101-26-8- PubChem CID
- 91696191
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 33,4 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 14
- Formalladung
- 0
- Komplexität
- 188
Physikochemische Eigenschaften
- Schmelzpunkt
- 154 °C · 154 °C
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- Very soluble in water and in ethanol (96 per cent).
- Aggregatzustand
- Solid
- Farbe
- White to Almost white
- Merck
- 14 · 14,7977
- BCS Class
- 3 · 3
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1
- InChIKey
- VNYBTNPBYXSMOO-UHFFFAOYSA-M
- SMILES
- C1(C=CC=[N+](C)C=1)OC(=O)N(C)C.[Br-]
- CAS Datenbank
- 101 · 101-26-8(CAS DataBase Reference)
- EPA chemische Informationen
- 3 · Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1) (101-26-8)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 2811 6.1/PG 2
- hs_code
- 2933399090
- RTECS-Nr.
- UU5270000
- risk_code
- 26/27/28-43
- Toxizität
- man,TDLo,oral,9mg/kg (9mg/kg),PERIPHERAL NERVE AND SENSATION: FASCICULATIONS,Israel Journal of Medical Sciences. Vol. 27, Pg. 659, 1991.
- hazard_code
- T+
- safety_code
- 22-36/37/39-45
- hazard_class
- 6.1
- packing_group
- II
- Speicherklasse
- 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- Giftige Stoffe Daten
- 101-26-8(Hazardous Substances Data)
- Hazard Classifications
- Acute Tox. 1 InhalationAcute Tox. 2 DermalAcute Tox. 2 OralSkin Sens. 1
Chemie und Industrie
Anwendungen
BeschreibungPyridostigmine is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.35 and 1 μM, respectively, for the human enzymes). Pyridostigmine (10 μM) reduces decreases in AChE activity induced by the organophosphate pesticides diisopropyl fluorophosphate, chlorpyrifos-oxon, diazinon-oxon, paraoxon, and malaoxon in isolated bovine red blood cells. It also reduces soman-induced membrane depolarization and decreases in AChE activity in isolated human muscle bundles in a concentration-dependent manner. Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia and increases in sympathetic tone in mice following myocardial infarction induced by left coronary artery ligation. Formulations containing pyridostigmine have been used in the treatment of myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.
VerwendenCholinergic, used in the treatment of myasthenia gravis, and is a pre-exposure antidote to chemical warfare agents.
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上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
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