Hexaflumuron

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

Do NOT wash away into sewer. Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. ... Provision to contain effluent from fire extinguishing.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

LD50 Mallard ducks oral >2000 mg/kg

LD50 Bee oral & contact >0.1 mg/bee

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 29,300(SRC), determined from a log Kow of 5.68(2) and a regression-derived equation(3), indicates that hexaflumuron is expected to be immobile in soil(SRC). Volatilization of hexaflumuron from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.0X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 4.43X10-7 mm Hg(2), and water solubility, 0.027 mg/l(2). Hexaflumuron is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). However, adsorption to soil is expected to attenuate volatilization(SRC). In soil, the aerobic biodegradation half-life for hexaflumuron ranged from 56 to 190 days under different moisture and temperature conditions(4). Under anaerobic conditions, the biodegradation half-life for hexaflumuron ranged from 40-64 days at 25 °C(4). Photodegradation of hexaflumuron may be important since it has a half-life in water of 6.3 days(4).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 29,300(SRC), determined from a log Kow of 5.68(2) and a regression-derived equation(3), indicates that hexaflumuron is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.0X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 4.4X10-7 mm Hg(2), and water solubility, 0.027 mg/l(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.2 hrs and 8.5 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 290 months if adsorption is considered(4). According to a classification scheme(5), an estimated BCF of 4,700(SRC), from its log Kow (2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is very high(SRC). Based on soil biodegradation studies, hexaflumuron is expected to biodegrade in water under aerobic and anaerobic conditions(SRC). In soil the aerobic biodegradation half-life for hexaflumuron ranged from 56 to 190 days under different moisture and temperature conditions(7). Under anaerobic conditions in soil, the biodegradation half-life for hexaflumuron ranged from 40-64 days at 25 °C(7). The hydrolysis of hexaflumuron in natural water was a first order process with a mean half-life of 42.3 days(7). The aqueous photolysis of hexaflumuron resulted in 2,6-difluorobenzamide, 3,5-dichloro-4-hydroxyaniline, and CO2 as the major degradation products. The photodegradation was a first order process with a half-life of approx 6.3 days(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexaflumuron, which has a vapor pressure of 4.43X10-7 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere(SRC). Vapor-phase hexaflumuron is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18.3 hrs(SRC), calculated from its rate constant of 21X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase hexaflumuron may be removed from the air by wet and dry deposition(SRC). Based on aqueous photolysis studies(2), hexaflumuron has the potential for direct photolysis(SRC).

/AQUATIC SPECIES/ Hexaflumuron, an insect growth regulator (IGR), was found to be nonlethal to four species of larvivorous fish, Poecilia reticulata, Gambusia affinis, Aplocheilus blochii and Tilapia mossambica at | 1.0 mg/l. These species were found to be tolerant with higher LD50 values ranging from 2.21-3.097 mg/l. Absolute survival (100%) was observed in all the four species at 1.0 mg/l for more than 8 days. Fish safety factor or suitability index computed for each fish species against the three vector mosquitoes showed maximum value for P. reticulata which indicated its higher tolerance than other species. Fishes that exhibited decreased swimming activity on exposure at 1.0 mg/l regained normal activity on withdrawal of exposure. No adverse effect was noticed in the reproduction of G. affinis.

The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in fish. The substance may cause long-term effects in the aquatic environment. Avoid release to the environment in circumstances different to normal use.

Hexaflumuron is strongly adsorbed on a wide range of soils(1,4). The Koc of hexaflumuron is estimated as 29,300(SRC), using a log Kow of 5.68(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that hexaflumuron is expected to be immobile in soil(SRC). Soil Kd (desorption constants) values ranged from 147 to 1,326(4) and soil Kom values ranged from 3,096 to 41,170(1).

AEROBIC: Hexaflumuron biodegrades under aerobic conditions(SRC). Levels of radioactivity in the 14CO2 traps from and aerobic soil degradation experiment were very low with a total of only 0.7-2.1% of the applied activity observed 84 days after treatment with (14C-aniline)hexaflumuron(1). However, previous investigations using benzoyl 14C-labeled hexaflumuron have shown greater amounts of 14CO2 suggesting that this part of the molecule is more readily degraded to CO2(1). TLC of the extracts of the soil samples incubated under aerobic conditions showed the presence of two metabolites, 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline and 2,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenylurea in addition to the parent(1). Levels of both metabolites generally increased with incubation time, and the greatest levels were observed at the higher temperatures and moisture contents(1). The half-life of (14C-aniline)hexaflumuron in Castle Rising soil under different temperature and moisture regimes were as follows: 159 days (moisture, 50% of 0.33 bar; 25 °C); 90 days (moisture, 75% of 0.33 bar; 25 °C); 64 days (moisture, 100% of 0.33 bar; 25 °C); 190 days (moisture, 75% of 0.33 bar; 10 °C); 90 days (moisture, 75% of 0.33 bar; 25 °C); 56 days (moisture, 75% of 0.33 bar; 35 °C)(1).

ANAEROBIC: Analysis of the anaerobic soils showed the presence of 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline as the major metabolite (8-18% of applied activity), with an unknown metabolite of greater polarity than any of the reference standards observed at levels up to 5% of applied radioactivity(1). Half-lives of (14C-aniline)hexaflumuron at 25 °C under anaerobic conditions were in the range 40-64 days(1).

An estimated BCF of 4,700 was calculated for hexaflumuron(SRC), using a log Kow of 5.68(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC).

The Henry's Law constant for hexaflumuron is estimated as 1.0X10-5 atm-cu m/mole(SRC) derived from its vapor pressure, 4.43X10-7 mm Hg(1), and water solubility, 0.027 mg/l(1). This Henry's Law constant indicates that hexaflumuron is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2.2 hrs(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 8.5 days(SRC). Hexaflumuron's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). However, volatilization from moist soil and water surfaces is expected to be attenuated by adsorption(SRC). The estimated volatilization half-life from a model pond is 290 months if adsorption is considered(3). Hexaflumuron is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ The effects of five benzoylphenylurea insecticides /including/ ...hexaflumuron... were comparatively evaluated on hematological parameters in rats. Sixty adult Wistar-rats were divided into five dose groups and a control group. Daily doses of 100 mg/kg of each tested insecticide were administered by gavage for 28 days, after which rats were sacrificed and blood was taken for examination. Parameters measured were red blood cell count, hemoglobin (Hb), hematocrit, mean corpuscular volume, mean corpuscular Hb concentration, methemoglobin (metHb), and reticulocyte counts. Results showed that treatment with insecticides at the dose given did not produce any overt signs of toxicity. ...The reticulocyte level was increased in all treated groups, even at dose levels of 50mg/kg. The authors conclude that the metHb level incr and reticulocyte incr are the most sensitive parameters, but that one might be independent of the other.

New Active Ingredients ... includes pesticide active ingredients initially registered after November 1, 1984, that currently have active product registrations. By law, these newer pesticides are not subject to the reregistration program. They must, however, meet the new safety standard of the FQPA, and will be reviewed on a 15-year cycle under the registration review program. ... Active Ingredient Number: 118202; Tpye of Pesticide: conventional-insecticide/termiticide; Use Site: non-food use, wood, ornamentals; Year: 1994.