Imazapic

Suitable extinguishing media: foam, dry powder, carbon dioxide, water spray. /Cadre Herbicide/

Hazards during fire-fighting: Carbon monoxide, carbon dioxide, nitrogen oxide, nitrogen dioxide, hydrocarbons. If product is heated above decomposition temperature, toxic vapors will be released. The substances/groups of substances mentioned can be released if the product is involved in a fire. /Cadre Herbicide/

Firefighters should be equipped with self-contained breathing apparatus and turn-out gear. /Cadre Herbicide/

Evacuate area of all unnecessary personnel. Contain contaminated water/firefighting water. Do not allow to enter drains or waterways. /Cadre Herbicide/

Do not contaminate water, food or feed by storage or disposal. ... Keep from freezing, do not store below 20 °F. /Cadre Herbicide/

Keep only in the original container in a cool, dry, well-ventilated place away from ignition sources, heat or flame. Protect containers from physical damage. Protect against contamination. /Cadre Herbicide/

Segregate from incompatible substances. Segregate from foods and animal feeds. Segregate from textiles and similar materials. /Cadre Herbicide/

Cleanup: Dike spillage. Pick up with suitable absorbent material. Place into suitable containers for reuse or disposal in a licensed facility. Spilled substance/product should be recovered and applied according to label rates whenever possible. If application of spilled substance/product is not possible, then spills should be contained, solidified, and placed in suitable containers for disposal. After decontamination, spill area can be washed with water. Collect wash water for approved disposal. /Cadre Herbicide/

Cleanup: Dike spillage. Pick up with suitable absorbent material. Place into suitable containers for reuse or disposal in a licensed facility. Spilled substance/product should be recovered and applied according to label rates whenever possible. If application of spilled substance/product is not possible, then spills should be contained, solidified, and placed in suitable containers for disposal. After decontamination, spill area can be washed with water. Collect wash water for approved disposal. /Cadre Herbicide/

Personal precautions: Take appropriate protective measures. Clear area. Shut off source of leak only under safe conditions. Extinguish sources of ignition nearby and downwind. Ensure adequate ventilation. Wear suitable personal protective equipment. /Cadre Herbicide/

Environmental precautions: Do not discharge into the subsoil/soil. Do not discharge into drains/surface waters/groundwater. Contain contaminated water/firefighting water. /Cadre Herbicide/

Cleanup: Dike spillage. Pick up with suitable absorbent material. Place into suitable containers for reuse or disposal in a licensed facility. Spilled substance/product should be recovered and applied according to label rates whenever possible. If application of spilled substance/product is not possible, then spills should be contained, solidified, and placed in suitable containers for disposal. After decontamination, spill area can be washed with water. Collect wash water for approved disposal. /Cadre Herbicide/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Wastes resulting from the use of this product may be disposed of on site or at an approved waste disposal facility. /Cadre Herbicide/

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part 170. /Cadre Herbicide/

Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application. /Cadre Herbicide/

Do not apply directly to water, or to areas where surface water is present, or to intertidal areas blow the mean high water mark. /Cadre Herbicide/

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 12 hours. /Cadre Herbicide/

For more Preventive Measures (Complete) data for Imazapic (8 total), please visit the HSDB record page.

Tolerances are established for combined residues of the herbicide imazapic, (+/-)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1 H -imidazol-2-yl]-5-methyl-3-pyridinecarboxylic acid and its metabolite (+/-)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1 H -imidazol-2-yl]-5-hydroxymethyl-3-pyridinecarboxylic acid, both free and conjugated, in or on the following food commodities: [Table#7859]

Tolerances are also established for the combined residues of the herbicide imazapic, (+/-)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1 H -imidazol-2-yl]-5-methyl-3-pyridinecarboxylic acid and its free metabolite (+/-)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1 H -imidazol-2-yl]-5-hydroxymethyl-3-pyridinecarboxylic acid, in or on the following food commodities: [Table#7860]

Personal Protective Equipment (PPE). Applicators and other handlers must wear: Long-sleeved shirt and long pants; Chemical-resistant gloves made of any waterproof material; Shoes plus socks. /Cadre Herbicide/

Restricted entry interval (REI) of 12 hours. PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water, is: coveralls, chemical-resistant gloves made of any waterproof material, shoes plus socks. /Cadre Herbicide/

LC50; Species: Anas platyrhynchos (Mallard Duck) diet >5000 mg/kg /Conditions of bioassay not specified in source examined/

LC50; Species: Colinus virginianus (Northern Bobwhite Quail) diet >5000 mg/kg /Conditions of bioassay not specified in source examined/

LD50; Species: Anas platyrhynchos (Mallard Duck) diet >2150 mg/kg /Conditions of bioassay not specified in source examined/

LD50; Species: Colinus virginianus (Northern Bobwhite Quail) >2150 mg/kg /Conditions of bioassay not specified in source examined/

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 3(SRC), determined from a log Kow of 0.393(2) and a regression-derived equation(3), indicates that imazapic is expected to have very high mobility in soil(SRC). The pKa values of imazapic are 2.0, 3.6, and 11.1(2), indicating that this compound will almost entirely exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization from moist soil is not expected because the compound exists as an anion and anions do not volatilize. Imazapic is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.7X10-12 mm Hg at 25 °C(SRC), determined from a fragment constant method(5). A microbial degradation half-life range in soil of 31 to 410 days indicates biodegradation may be dependent on soil conditions(2).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 3(SRC), determined from a log Kow of 0.393(2) and a regression-derived equation(3), indicates that imazapic is not expected to adsorb to suspended solids and sediment(SRC). The pKa values of 2.0, 3.6, and 11.1(2) indicate imazapic will exist almost entirely in anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(SRC). According to a classification scheme(4), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data in water were not available(SRC, 2011).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), imazapic, which has an estimated vapor pressure of 7.7X10-12 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase imazapic may be removed from the air by wet or dry deposition(SRC). Imazapic absorbs light at wavelengths >290 nm(4), and therefore may be susceptible to direct photolysis by sunlight(SRC).

/AQUATIC SPECIES/ Cyprinus carpio was exposed to imazethapyr and imazapic at laboratory and at field conditions. The laboratory experiment was carried out for 7 days and at rice field for 7, 30 and 90 days. Oxidative stress parameters and antioxidant profile were studied as well as metabolic parameters. After 7 days, brain AChE activity increases in laboratory and field, but in muscle, reduction was observed only in laboratory. At the same period, brain and muscle thiobarbituric acid reactive substances (TBARS) and liver catalase cationic amino transporters (CAT) increase in the laboratory. Metabolic parameters showed changes in both conditions and exposure periods. After 30 days in rice field, brain AChE activity decreases and in muscle it was enhanced. After 90 days in field, only muscle AChE activity was reduced. The disorders in oxidative stress parameters and metabolism remained, indicating mainly a protein catabolism. This study pointed out short- and long-term effects of rice herbicides at environmentally relevant concentrations on toxicological parameters in tissues of C. carpio.

The Koc of imazapic is estimated as 3(SRC), using a log Kow of 0.393(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that imazapic is expected to have very high mobility in soil. The pKa values of imazapic are 2.0, 3.3, and 11.1(1), indicating that this compound will almost entirely exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

An estimated BCF of 3 was calculated in fish for imazapic(SRC), using a log Kow of 0.393(1) and a regression-derived equation(2). Using a modeling approach based on the quantitative structure-activity relationship (QSAR), a log BCF of -0.88215, corresponding to a BCF of >1 was calculated(3). According to a classification scheme(3), these estimated BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC).

This research was aimed at understanding the dynamics of the herbicides ... imazapic [2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-methylnicotinic acid] ... in two soils of different physicochemical properties. To accomplish such intent, several greenhouse experiments were run. The bioavailability of imazapic (0; 98 and 122.5 g ha-1) was measured in samples from a sandy loam soil and a clay soil, by sowing a bioindicator (Brachiaria decumbens /signal grass/), at 0, 25, 50, 75 and 100 days after herbicides application (DAA). ... Imazapic provided a short bioavailability in relation to B. decumbens, independent of rates applied.

The pKa values of 2.0, 3.6, and 11.1(1) indicate imazapic will exist almost entirely in anion form at pH values of 5 to 9 and therefore volatilization from water and moist soil surfaces is not expected to be an important fate process. Imazapic is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.7X10-12 mm Hg(SRC), determined from a fragment constant method(2).

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Imazapic (AC 263,222, purity: 93.7%) was mixed with saline and the resulting slurry was applied to the clipped skin of 6 New Zealand White rabbits/sex/dose at dose levels of 0 (saline), 250, 500, or 1000 mg/kg/day for 6 hrs/day 5 days/week for 3 consecutive weeks using an occlusive dressing. No mortalities occurred. No treatment-related clinical signs were observed. No skin irritation was observed at the treatment sites. No effect on body weight was observed. Hematological and clinical chemistry investigations revealed no effects of biological significance. No effect on mean relative organ weights was observed. Macroscopic and microscopic examinations revealed no treatment-related abnormalities. ... NOEL (M/F, systemic and skin) = 1000 mg/kg/day based on no treatment-related effects at the highest dose tested.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ 20 CD (Crl:CD (SD)) rats per sex per group received imazapic (AC 263,22, purity: 93.7%) in the diet at 0 (basal diet), 5,000, 10,000, and 20,000 ppm for 13 weeks. Average test article intake for males and females was 408, 804, and 1625 mg/kg/day at 5,000, 10,000, and 20,000 ppm respectively during the 13-week treatment period. No deaths. Food consumption was significantly increased for males at 5,000,10,000, and 20,000 ppm and for females at 10,000 ppm during the first week of the study. During the remainder of the study, food consumption for treated groups was comparable to controls. Bodyweights were slightly increased (not statistically significant) for males at 5,000 and 10,000 ppm during the 13-week study period. Bodyweights for females in all treated groups and for males at 20,000 ppm were comparable to controls over the entire study period. Bodyweight gains for treated groups (both sexes) over the 13-week period were generally comparable to controls. No treatment-related findings were noted for hematology, serum chemistry, urinalysis, necropsy, organ weights, or histopathology. ... NOEL = 20,000 ppm (1625 mg/kg/day). No adverse effects.

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ 65 CD-1 (Crl(ICR)BR) mice/sex/group received imazapic (AC 263,222, purity: 96.9%) in the diet at 0 (basal diet); 1,750; 3,500; and 7,000 ppm for 18 months. 10 per sex/group were necropsied at 12 months. Mean daily intake of imazapic (AC 263,222) was 271 +/- 52, 551 +/- 104, and 1134 +/- 265 mg/kg/day for males and 369 +/- 87, 733 +/- 184, 1442 +/- 348 mg/kg/day for females at 1,750, 3,500, and 7,000 ppm respectively over the 18-month treatment period. Slight reductions in male bodyweight were noted through week 16, but bodyweight gain was unaffected through the 18 month study period and female bodyweight and bodyweight gain were comparable to controls. No treatment-related effects on survival, food consumption, hematology, gross pathology, organ weights, or histopathology were recorded. No evidence of oncogenicity. Chronic NOEL > or =7,000 ppm.

Imazapic is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(1). Imazapic absorbs at wavelengths >290 nm(2), and therefore it may be susceptible to direct photolysis by sunlight(SRC). When irradiated at lambda >290, imazapic (10 ppm in aqueous solution) was slowly degraded. After 2 hours, 98% of imazapic still remained; after 24 hours, imazapic decreased to 22% of original solution concentration(2).

Tolerances are established for combined residues of the herbicide imazapic, (+/-)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1 H -imidazol-2-yl]-5-methyl-3-pyridinecarboxylic acid and its metabolite (+/-)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1 H -imidazol-2-yl]-5-hydroxymethyl-3-pyridinecarboxylic acid, both free and conjugated, in or on the following food commodities: [Table#7861]

Tolerances are also established for the combined residues of the herbicide imazapic, (+/-)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1 H -imidazol-2-yl]-5-methyl-3-pyridinecarboxylic acid and its free metabolite (+/-)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1 H -imidazol-2-yl]-5-hydroxymethyl-3-pyridinecarboxylic acid, in or on the following food commodities: [Table#7862]

New Active Ingredients ... includes chemicals not previously registered as pesticides, as well as pesticide active ingredients initially registered after November 1, 1984 and that currently have active product registrations. By law, these pesticides must meet new safety standards, such as those described in the Food Quality Protection Act of 1996 and, if new safety standards are met, will be reviewed again on a 15-year cycle. Cadre is designated by EPA as a New Pesticide Active Ingredient. Active Ingredient Number: 129041; Type of Pesticide: herbicide; Use Site: food use; Year: 1996.

For imazapic (USEPA/OPP Pesticide Code: 129041) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

For imazapic-ammonium (USEPA/OPP Pesticide Code: 128943) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ /Imazapic-ammonium/

Herbicide

For post- and pre-emergence residual control of a wide range of annual and perennial weeds in pasture, rangeland and non-cropland areas.

This is a man-made compound that is used as a pesticide.

Soluble concentrate; water dispersible granule.

Premix Partners: Glyphosate; Imazapyr

Cadre Herbicide (Basf Corporation) Imazapic-ammonium 23.6%. /Imazapic-ammonium/

Plateau Herbicide (Basf Corporation) Imazapic-ammonium 23.6%. /Imazapic-ammonium/

For more Formulations/Preparations (Complete) data for Imazapic (25 total), please visit the HSDB record page.