Miransertib Mesylate
Grundinformationen
- CAS
1817727-88-0- Standard-SMILES
CS(=O)(=O)O.CS(=O)(=O)O.Nc1ncccc1-c1nc2ccc(-c3ccccc3)nc2n1-c1ccc(C2(N)CCC2)cc1- InChIKey
LNSQWHNDOWEZII-UHFFFAOYSA-N- Summenformel
- C29H32N6O6S2
- Durchschnittliche Molmasse
- 624,7 g/mol
- Monoisotopische Masse
- 624,18247511
Überblick
Miransertib Mesylate is the mesylate salt form of miransertib, an orally bioavailable inhibitor of the serine/threonine protein kinase AKT (protein kinase B), with potential antineoplastic activity. Miransertib binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. The AKT signaling pathway is often deregulated in cancer and is associated with tumor cell proliferation, survival and migration.
Namen und Bezeichner
- Bevorzugter Name
- Miransertib Mesylate
- IUPAC
- 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine;methanesulfonic acid
Namen und Synonyme
Miransertib mesylateMiransertib dimesylateARQ 092 mesylateMiransertib mesylate [USAN]1817727-88-0ARQ-092 MESYLATEUNII-F9613932V7F9613932V7Miransertib mesylate (USAN)2-Pyridinamine, 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo(4,5-b)pyridin-2-yl)-, methanesulfonate (1:2)3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO(4,5-B)PYRIDIN-2-YL)PYRIDIN-2-AMINE DIMETHANESULFONATE3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine dimethanesulfonate
Weitere Namen anzeigen
3-{3-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl}pyridin-2-amine dimethanesulfonateRefChem:159032MIRANSERTIB BISMESYLATEorb1739328CHEMBL4298151SCHEMBL29638213D11508
Datenbank-Bezeichner
- CAS
1817727-88-0- PubChem CID
- 92135934
- ChEMBL
CHEMBL4298151
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 221 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 11
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 43
- Formalladung
- 0
- Komplexität
- 746
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