7-Amino-4-methylcumarin

7-Amino-4-methylcoumarin

HCID 92249
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Grundinformationen

CAS
26093-31-2
Standard-SMILES
Cc1cc(=O)oc2cc(N)ccc12
InChIKey
GLNDAGDHSLMOKX-UHFFFAOYSA-N
Summenformel
C10H9NO2
Durchschnittliche Molmasse
175,18 g/mol
Monoisotopische Masse
175,06332853

Überblick

Coumarin 120 is a member of 7-aminocoumarins. It has a role as a fluorochrome.

Namen und Bezeichner

Bevorzugter Name
7-Amino-4-methylcoumarin
IUPAC
7-amino-4-methylchromen-2-one
Lokaler Name
7-Amino-4-methylcumarin
Englischer Name
Coumarin 120
Summenformel
C10H9NO2
Molmasse
175.18

Namen und Synonyme

7-Amino-4-methylcoumarin26093-31-2Coumarin 1207-Amino-4-methyl-2H-chromen-2-one2H-1-Benzopyran-2-one, 7-amino-4-methyl-4-Methyl-7-aminocoumarinCoumarin, 7-amino-4-methyl-7-AMINO-4-METHYL-CHROMEN-2-ONE7-amino-4-methylchromen-2-oneOCY3JCT44X7-amino-4-methyl-coumarinNSC-45796
Weitere Namen anzeigen
C1207-AMCAMC 7-Amino-4-MethylcoumarinH-MCAC 120
CHEBI:51771DTXSID40885333RefChem:545384DTXCID0010247182H-1-benzopyran-2-one, 7-amino-4-methyl247-454-8Coumarin 440AMC

Datenbank-Bezeichner

CAS
26093-31-2
PubChem CID
92249
DTXSID
DTXSID40885333
ChEMBL
CHEMBL270672
ChEBI
CHEBI:51771
UNII
OCY3JCT44X
EC Number
247-454-8
Nikkaji
J150.531I

Eigenschaften

Berechnete Struktureigenschaften

XLogP
1,6
Polarare Oberfläche (TPSA)
52,3 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
3
Frei drehbare Bindungen
0
Schwere Atome
13

Experimentelle und physikochemische Eigenschaften

Chemical ClassesDyes -> Coumarin Dyes
DrugsPharmaceuticals -> Listed in ZINC15
SpringerMaterials PropertiesChemical shift
Physical DescriptionPowder; [MSDS]

Physikochemische Eigenschaften

Schmelzpunkt
223 · 223-226 °C (lit.)
Siedepunkt
306.47 °C · 306.47°C (rough estimate)
Dichte
1.1999 · 1.1999 (rough estimate)
Brechungsindex
1.506 · 1.5060 (estimate)
storage temp.
2 · 2-8°C
Löslichkeit
Soluble in acetone (10 mg/ml) dimethyl sulfoxide (10 mg/ml) and dimethylformamide.

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 49 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Hazards SummaryMay cause skin and respiratory tract irritation; [MSDSonline] The 3 laser dyes tested for skin sensitization were found to be negative. [Blackwell Synergy - Contact Dermatitis, Volume 21, Issue 3, Page 141-147, September 1989] See Coumarin.
Hazard Classes and CategoriesSkin Irrit. 2 (100%)

Sicherheitsdaten

wgk
3
tsca
TSCA listed
hs_code
32049000
risk_code
36/37/38-20/21/22
hazard_code
Xi,Xn
hazard_note
Irritant

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 1 Eintrag

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

Verwendung und Herstellung

Uses · 2 Einträge

Coumarins are used as laser dyes. Coumarin 120 (Kodak) is the parent compound of the oldest aminocoumarin laser dye, which is Coumarin 311 (Kodak). [Ullmann: Laser Dyes]

Synthetic Polymer MALDI Matrix Compounds

General Manufacturing Information2H-1-Benzopyran-2-one, 7-amino-4-methyl-: ACTIVE

Anwendungen

VerwendenCoumarin 120 is widely used fluorophore, well-known for preparing fluorogenic substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.

Vor- und nachgelagerte Produkte

Anbieter100 Anbieter

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
韶远科技（上海）有限公司021-50795510 4000665055 · [email protected]
科瑞迪化学400-821-5857 021-64326257 · [email protected]

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