Grundinformationen
- CAS
692-04-6- Standard-SMILES
CC(=O)NCCCC[C@H](N)C(=O)O- InChIKey
DTERQYGMUDWYAZ-ZETCQYMHSA-N- Summenformel
- C8H16N2O3
- Durchschnittliche Molmasse
- 188,22 g/mol
- Monoisotopische Masse
- 188,11609238
Überblick
N(6)-acetyl-L-lysine is an N6-acyl-L-lysine where the N6-acyl group is specified as acetyl. It has a role as a human metabolite. It is a N(6)-acyl-L-lysine and an acetyl-L-lysine. It is a tautomer of a N(6)-acetyl-L-lysine zwitterion.
Namen und Bezeichner
- Bevorzugter Name
- epsilon-Acetyl-L-lysine
- IUPAC
- (2S)-6-acetamido-2-aminohexanoic acid
- Lokaler Name
- N-ε-Acetyl-L-lysin
- Englischer Name
- N-epsilon-Acetyl-L-lysine
- Summenformel
- C8H16N2O3
- Molmasse
- 188.22
Namen und Synonyme
692-04-6N6-Acetyl-L-lysineN-Epsilon-acetyllysineOmega-acetyllsineN(6)-acetyllsine(2S)-2-amino-6-acetamidohexanoic acidepsilon-Acetyl-L-lysine470AD5VY1XDTXSID90862371RefChem:921071DTXCID401527695N-epsilon-Acetyl-L-lysine
Weitere Namen anzeigen
lys(ac)N-EPSILON-ACETYL-L-LYSNSC 102777LYSINE(AC)-OHH-L-LYS(AC)-OHNε-Ac-L-Lys-OHNε-Acetyllysine
H-Lys(Ac)-OHNepsilon-Acetyl-L-lysinen6-acetyllysine(S)-6-Acetamido-2-aminohexanoic acidNe-AcetyllysineN(6)-Acetyl-L-lysineN(6)-ACETYLLYSINEMFCD00002639
Datenbank-Bezeichner
- CAS
692-04-6- PubChem CID
- 92832
- DTXSID
DTXSID90862371- ChEMBL
CHEMBL1230958- ChEBI
CHEBI:17752
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -2,8
- Polarare Oberfläche (TPSA)
- 92,4 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 13
- Formalladung
- 0
- Komplexität
- 182
Experimentelle und physikochemische Eigenschaften
Melting Point250 °C
Physical DescriptionSolid
Collision Cross Section142.3 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
Physikochemische Eigenschaften
- Schmelzpunkt
- 250 °C · 250 °C (dec.)(lit.)
- Siedepunkt
- 323.23 °C · 323.23°C (rough estimate)
- Dichte
- 1.1793 · 1.1793 (rough estimate)
- Brechungsindex
- 1.45 · 1.4500 (estimate)
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- Aqueous Base (Slightly), Water (Slightly)
- Aggregatzustand
- Powder
- pka
- 2.53 · 2.53±0.24(Predicted)
- Farbe
- White
- Wasserlöslichkeit
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29241900
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 24/25-36-26
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
Tissue LocationsPlacenta
Cellular LocationsCytoplasm
Anwendungen
BeschreibungAcetyllysine (or acetylated lysine) is an acetyl-derivative of the amino acid lysine. There are multiple forms of acetyllysine - this article refers to N-ε-acetyl-L-lysine. The other form is N-α-acetyl-Llysine. In proteins, the acetylation of lysine residues is an important mechanism of epigenetics. It functions by regulating the binding of histones to DNA in nucleosomes and thereby controlling the expression of genes on that DNA. Non-histone proteins are acetylated as well. Unlike the functionally similar methyllysine, acetyllysine does not carry a positive charge on its side chain. Histone acetyltransferases (HATs) catalyze the addition of acetyl groups from acetyl-CoA onto certain lysine residues of histones and non-histone proteins. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from acetylated lysines. Acetyllysine can be synthesized from lysine by the selective acetylation of the terminal amine group.
VerwendenN-Epsilon-acetyl-l-lysine is used in the metabolomics study on the combined effect of cocaine and ethanol via liquid chromatography-mass spectrometry metabolomics approach.
Anbieter100 Anbieter
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖南韵邦生物科技股份有限公司0731-88532326 13319508186 · [email protected]
盐城通铭生物科技有限公司15195160625 · [email protected]
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…