Estr-4-en-3,17-dion
(+)-Estr-4-ene-3,17-dione
Grundinformationen
- CAS
734-32-7- Standard-SMILES
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@H]43)[C@@H]1CCC2=O- InChIKey
JRIZOGLBRPZBLQ-QXUSFIETSA-N- Summenformel
- C18H24O2
- Durchschnittliche Molmasse
- 272,4 g/mol
- Monoisotopische Masse
- 272,17763001
Überblick
19-Norandrostenedione is a 3-oxo steroid.
Namen und Bezeichner
- Bevorzugter Name
- (+)-Estr-4-ene-3,17-dione
- IUPAC
- (8R,9S,10R,13S,14S)-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione
- Lokaler Name
- Estr-4-en-3,17-dion
- Englischer Name
- Norandrostenedione
- Summenformel
- C18H24O2
- Molmasse
- 272.38
Namen und Synonyme
19-Norandrostenedione734-32-719-Norandrost-4-ene-3,17-dione19-nor-4-androstene-3,17-dioneNordionedelta4-Estrene-3,17-dionedelta,4-Estrene-3,17-dioneU90987PVU5(+)-Estr-4-ene-3,17-dioneNSC-12164DTXSID5086239219-nor-A-dione
Weitere Namen anzeigen
BolandioneESTRENONE19-demethyl-4-androstenedioneNSC 121644-ESTREN-3,17-DIONE
RefChem:79523DTXCID601334157(1S,2R,10R,11S,15S)-15-methyltetracyclo(8.7.0.02,?.011,1?)heptadec-6-ene-5,14-dione211-995-8NorandrostenedioneEstr-4-ene-3,17-dione(+)-19-Norandrost-4-ene-3,17-dione19-Nor-4-androstenedione
Datenbank-Bezeichner
- CAS
734-32-7- PubChem CID
- 92834
- DTXSID
DTXSID50862392- ChEBI
CHEBI:34187
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,5
- Polarare Oberfläche (TPSA)
- 34,1 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 20
- Formalladung
- 0
- Komplexität
- 504
Experimentelle und physikochemische Eigenschaften
Drugs
DEA NFLIS-Drug Category -> Steroids
DEA NFLIS-Drug Category -> Steroids
DEA Schedule III Controlled Substance -> Anabolic steroids
Pharmaceuticals -> Listed in ZINC15
Endocrine DisruptorsPotential endocrine disrupting compound
Physikochemische Eigenschaften
- Schmelzpunkt
- 169 · 169-172°C
- Siedepunkt
- 433.4 · 433.4±45.0 °C(Predicted)
- Dichte
- 1.13 · 1.13±0.1 g/cm3(Predicted)
- Dampfdruck
- 0.001 Pa · 0.001Pa at 25℃
- storage temp.
- Refrigerator
- Löslichkeit
- 25 mg/ml; · DMF: 25 mg/ml; DMSO: 15 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
- Aggregatzustand
- A crystalline solid
- Wasserlöslichkeit
- 191 mg/L · 191mg/L at 20℃
- InChI
- InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,13-16H,2-9H2,1H3/t13-,14+,15+,16-,18-/m0/s1
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P264, P270, P273, P280, P301+P317, P302+P352, P317, P318, P321, P330, P362+P364, P391, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 15 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
DEA schedule III controlled substance
Status: Active Update: 09-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/18736
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29372900
- risk_code
- 11-34
- hazard_code
- F,C
- safety_code
- 16-26-36/37/39-45
Chemie und Industrie
Pharmakologische Informationen
Mechanism of Action
19-Norandrostenedione may be metabolized to 19-nortestosterone in both men and women. 19-Norandrostenedione, also known as nandrolone, is the basic substance of some very popular injectable anabolic steroids, however 19-norandrostenedione is not metabolized to testosterone. Whether or not increases in 19-nortestosterone levels would be sustained long enough by taking 19-norandrostenedione to show an increase in nitrogen retention and muscle strength and mass is unknown. 19-Norandrostenedione has also been shown to bind to androgen receptors with high selectivity. Transactivation of androgen receptor dependent reporter gene expression was 10 times lower than that produced by dihydrotestosterone. [1]
Metabolism/MetabolitesSpecific metabolites of 19-nor-5-androstene-3, 17-dione are 19-nordehydroandrosterone and 19-nordehydroepiandrosterone.
Absorption, Distribution and ExcretionAbsorption appears variable, but some absorption does occur.
Anwendungen
VerwendenNorethindrone intermediate
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Nachgelagerte Produkte
Zugehörige Reaktionen
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