Grundinformationen
- CAS
2140-61-6- Standard-SMILES
Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)nc1N- InChIKey
ZAYHVCMSTBRABG-JXOAFFINSA-N- Summenformel
- C10H15N3O5
- Durchschnittliche Molmasse
- 257,24 g/mol
- Monoisotopische Masse
- 257,10117059
Überblick
5-methylcytidine is a methylcytidine.
Namen und Bezeichner
- Bevorzugter Name
- 5-Methylcytidine
- IUPAC
- 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one
- Lokaler Name
- 5-Methylcytidin
- Englischer Name
- 5-Methylcytidine
- Summenformel
- C10H15N3O5
- Molmasse
- 257.24
Namen und Synonyme
5-Methylcytidine2140-61-65-methyl-cytidineTL9PB228DCCHEBI:20607DTXSID401016977NSC-3639334-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2-dihydropyrimidin-2-one4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methyl-1,2-dihydropyrimidin-2-oneRefChem:913534DTXCID501475162218-390-8
Weitere Namen anzeigen
5-Me-CrNSC 3639335-Methyicytidine5-Methylcytidine>Cytarabine EP Impurity G5-METHYLCYTIDINE USP/EP/BPRNA modified nucleoside m5C
Cytidine, 5-methyl-MFCD000065484-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-oneM021115-Methyl-D-cytidine4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidin-2-oneCytarabine EP Impurity G
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -2
- Polarare Oberfläche (TPSA)
- 129 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 5
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 18
- Formalladung
- 0
- Komplexität
- 422
Experimentelle und physikochemische Eigenschaften
LogP
-2.01
-2.01
Melting Point213 °C
Physical DescriptionSolid
Collision Cross Section
160.46 Ų [M-H]- [CCS Type: DT; Method: stepped-field]
157.4 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
156.5 Ų [M+H]+
Physikochemische Eigenschaften
- Schmelzpunkt
- 212 · 212-215 °C (dec.) (lit.)
- Siedepunkt
- 537.5 · 537.5±60.0 °C(Predicted)
- Dichte
- 1.79 · 1.79
- Brechungsindex
- 15 ° · 15 ° (C=2, H2O)
- storage temp.
- -20 °C · Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29389090
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36-24/25
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
Cellular LocationsCytoplasm
Anwendungen
BeschreibungThe methylation of carbon 5 in cytidine (m5C, 5-methylcytidine) has been identified as a widespread epitranscriptomic mark. 5-Methylcytidine is mostly found in tRNA and rRNA. 5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine and is a minor constituent of RNA and DNA for certain organisms. Roughly one to two residues of 5-methylcytidine occur in every 1,000 RNA residues. It has been used in epigenetics research, especially in studies involving DNA methylation processes involved in the establishment of genomic imprinting and the control of gene expression and differentiation.
Verwenden5-Methylcytidine is a derivative of Cytidine (C998300), found in ribonucleic acids of animals, plants and bacteria. 5-Methylcytidine is a nucleoside found in liver emulsion that can inhibit the growth of spontaneous tumors of mammary gland origin in mice. 5-Methylcytidine is one of many nucleosides that can be used as biomedical marker using liquid chromatography and ion trap mass spectrometry coupling.
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