HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Piritramid
A 65 · R 3365 · Pirdolan · Piridolan · Dipidolor · Pirtramide · piritramide · Pirinitramide
Identifikatoren & physikalische Daten
| CAS No. | 302-41-0 |
|---|---|
| Summenformel | C27H34N4O |
| Durchschnittliche Molmasse | 430,6 g/mol |
| Monoisotopische Masse | 430,27326172 g/mol |
| SMILES | N#CC(CCN1CCC(C(N)=O)(N2CCCCC2)CC1)(c1ccccc1)c1ccccc1 |
| InChIKey | IHEHEFLXQFOQJO-UHFFFAOYSA-N |
| PubChem CID | 9331 |
| ChEMBL | CHEMBL559288 |
| ChEBI | CHEBI:135699 |
| EC No. | 206-124-3 |
| DTXSID | DTXSID00184293 |
| Lokaler Name | Piritramid |
Chemische & physikalische Eigenschaften
| XLogP | 3,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 73,4 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 32 |
| Formalladung | 0 |
| Komplexität | 638 |
| Arzneimittel | DEA NFLIS-Drug Category -> Narcotic AnalgesicsDEA Schedule I Controlled Substance -> OpiatesPharmaceuticals -> Synthetic Cannabinoids or Psychoactive CompoundsPharmaceuticals -> Listed in ZINC15 |
| LogP (Verteilungskoeffizient) | 3.91 |
| Human Drugs | Breast FeedingLactationMilk, HumanAnalgesics, OpioidNarcotics |
| Schmelzpunkt | 149.5 °C149-150° |
| Physical Description | Solid |
| Siedepunkt | 544.82°C (rough estimate) |
| Dichte | 1.0967 (rough estimate) |
| Brechungsindex | 1.5900 (estimate) |
| Lagerbedingungen | Controlled Substance, -20°C Freezer |
| Löslichkeit | Chloroform (Slightly), Methanol (Slightly) |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | 16.19±0.20(Predicted) |
| Farbe | White to Pale Beige |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P233, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | DEA schedule I controlled substance |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
| Alarmwort | Achtung |
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302 |
Anwendungen & Verwendung
Verwenden
Piritramide is a synthetic opioid commonly used in Germany and Austria for the analgesia of pediatric patients.