N-Methyl-N-2-propinylbenzolmetha-namin-hydrochlorid
Pargyline Hydrochloride
Grundinformationen
- CAS
306-07-0- Standard-SMILES
C#CCN(C)Cc1ccccc1.Cl- InChIKey
BCXCABRDBBWWGY-UHFFFAOYSA-N- Summenformel
- C11H14ClN
- Durchschnittliche Molmasse
- 195,69 g/mol
- Monoisotopische Masse
- 195,0814771
Überblick
Pargyline Hydrochloride is the hydrochloride salt form of pargyline, a monoamine oxidase (MAO) inhibitor with antidepressant activity. Pargyline selectively inhibits MAO type B, an enzyme catalyzing the oxidative deamination and inactivation of certain catecholamines, such as norepinephrine and dopamine, within the presynaptic nerve terminals. By inhibiting the metabolism of these biogenic amines in the brain, pargyline increases their concentration and binding to postsynaptic receptors. Increased receptor stimulation may cause downregulation of central receptors which may attribute to pargyline's antidepressant effect.
Namen und Bezeichner
- Bevorzugter Name
- Pargyline Hydrochloride
- IUPAC
- N-benzyl-N-methylprop-2-yn-1-amine;hydrochloride
- Lokaler Name
- N-Methyl-N-2-propinylbenzolmetha-namin-hydrochlorid
- Englischer Name
- Pargyline hydrochloride
- Summenformel
- C11H14ClN
- Molmasse
- 195.69
Namen und Synonyme
Pargyline hydrochloride306-07-0Pargyline HClEutonylN-Methyl-N-2-propynylbenzylamine hydrochlorideMO-911DTXSID1044647W70V6I2OMYNSC-43798A-19120DTXCID9024647NSC43798
Weitere Namen anzeigen
NSC 43798Parguline HCLpargylinechloridePARGYLINE HYDROCHLORParglycine hydrochloridePargylamine hydrochloridePargyline Hydrochloride (200 mg)PARGYLINE HYDROCHLORIDE USP/EP/BP
RefChem:58612206-175-1N-Methyl-N-propargylbenzylamine hydrochlorideN-benzyl-N-methylprop-2-yn-1-amine hydrochlorideEutonyl-tenPargyline chlorideMFCD00012492USAF A-19120
Datenbank-Bezeichner
- CAS
306-07-0- PubChem CID
- 9373
- DTXSID
DTXSID1044647- ChEMBL
CHEMBL1200425
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 3,2 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 13
- Formalladung
- 0
- Komplexität
- 159
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section134.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 160 · 160-163 °C(lit.)
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- 33.55 mg/mL · ≥33.55 mg/mL in EtOH; ≥51.6 mg/mL in H2O; ≥7.55 mg/mL in DMSO
- Aggregatzustand
- A crystalline solid
- Farbe
- 2 O · Crystals from EtOH/Et2O
- Biologische Quelle
- synthetic
- Wasserlöslichkeit
- 50 mg/mL, · water: 50mg/mL, clear, colorless to faintly yellow
- Merck
- 13 · 13,7110
- BRN
- 3699487 · 3699487
- InChI
- InChI=1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 183 reports by companies from 1 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Sicherheitsdaten
- F
- 10
- wgk
- 3
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 2921199990
- RTECS-Nr.
- DP6650000
- risk_code
- 22
- Toxizität
- LD50 orl-rat: 250 mg/kg 27ZQAG -,401,72
- hazard_code
- Xn
- safety_code
- 22-24/25
- hazard_class
- 6.1(b)
- packing_group
- III
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- Acute Tox. 3 Oral
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
Anwendungen
VerwendenPargyline hydrochloride has been used: as a histone demethylase inhibitor to treat monocytes to investigate whether various inhibitors affect training to maximize uptake into dopaminergic neurons (DA) neurons in experimental rats, to study its effect on discolouration of medullary tissues of sclerotia of S. sclerotiorum
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter100 Anbieter
北京华美互利生物化工010-56205725 · [email protected]
陕西科贝莱药物研发有限公司13119135307 13119135307 · [email protected]
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