5,6-Dihydro-9,10-dimethoxy-benzo(g)-1,3-benzo-dioxolo(5,6-a)-chinolizinium-sulfat (2:1)
Berberine sulfate anhydrous
Grundinformationen
- CAS
316-41-6- Standard-SMILES
COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.O=S(=O)([O-])[O-]- InChIKey
OJVABJMSSDUECT-UHFFFAOYSA-L- Summenformel
- C40H36N2O12S
- Durchschnittliche Molmasse
- 768,8 g/mol
- Monoisotopische Masse
- 768,19889576
Überblick
See also: Berberine (annotation moved to).
Namen und Bezeichner
- Bevorzugter Name
- Berberine sulfate anhydrous
- IUPAC
- bis(16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene);sulfate
- Lokaler Name
- 5,6-Dihydro-9,10-dimethoxy-benzo(g)-1,3-benzo-dioxolo(5,6-a)-chinolizinium-sulfat (2:1)
- Englischer Name
- BERBERINE SULFATE TRIHYDRATE
- Summenformel
- C20H18NO8S-
- Molmasse
- 432.42
Namen und Synonyme
Berberine sulphateBerberin sulfateBerberine sulfate (2:1)Neutral berberine sulfateErbenBerberine sulfate anhydrousFST3E667FFBenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, sulfate (2:1)Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydr0-9,10-dimethoxy-, sulfate (2:1)Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, sulfate (2:1)NSC-5355RefChem:1079543
Weitere Namen anzeigen
fate(2:1)berberinsuulfate(2:1)berberinsulfateberberinesulfate(2:1)Berberine sulfate 98%Beriberisulfatehydrateneutralberberinesulfate
206-258-2Berberine sulfateBerberine hemisulfate6190-33-6BerberalBerberine sulfate hydrateAI3-61947Berberine.sulfate.3H20
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 170 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 12
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 55
- Formalladung
- 0
- Komplexität
- 551
Experimentelle und physikochemische Eigenschaften
Color/FormYELLOW CRYSTALS
SolubilityINSOL IN CHLOROFORM /TRIHYDRATE/
DecompositionDISASTER HAZARD: DANGEROUS; WHEN HEATED TO DECOMPOSITION, EMITS HIGHLY TOXIC FUMES. /BERBERINE/
Other Experimental Properties
RED-YELLOW NEEDLES /TRIHYDRATE/
YELLOW NEEDLES /TRIHYDRATE/
SOLUBLE IN ABOUT 30 PARTS WATER, IN ALC /TRIHYDRATE/
Physikochemische Eigenschaften
- storage temp.
- Inert atmosphere,Room Temperature
- Aggregatzustand
- powder to crystal
- Farbe
- Off white to yellow powder
- Wasserlöslichkeit
- almost transparency
- Merck
- 14 · 14,1154
- InChIKey
- OJVABJMSSDUECT-UHFFFAOYSA-L
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Toxikologische Informationen
Human Toxicity Excerpts
TOXIC DOSES DEPRESS HEART (DIRECTLY & REFLEXLY THROUGH THE VAGUS), RELAX BLOOD VESSELS, DEPRESS RESPIRATIONS, & STIMULATE SMOOTH MUSCLE IN INTESTINES, BRONCHI, & POSSIBLY UTERUS. /BERBERINE/
AN ALKALOID POISON. IN TOXIC DOSES IT LOWERS TEMPERATURE, INCREASES PERISTALSIS, AND CAUSES DEATH BY CENTRAL PARALYSIS. /BERBERINE/
TOXIC BY INGESTION, INHALATION, AND SKIN ABSORPTION. /BERBERINE/
Non-Human Toxicity Excerpts
HISTOPATHOLOGICAL EXAM REVEALED NO CHANGES IN TISSUES & ORGANS OF RATS EVEN IN CASES WHEN BERBERINE SULFATE WAS GIVEN FOR 6 WK IN 0.5 G/KG DAILY ORAL DOSES.
BERBERINE SULFATE (10-15 MG/KG, IP) DEPRESSED CNS AND CAUSED LACRIMATION, PILOMOTOR ERECTION, & PTOSIS IN MICE. IT CAUSED A MARKED TAMING EFFECT AS EVIDENCED BY BODY GRASP & HEAD TAP TEST. PENTOBARBITONE SLEEPING TIME WAS MARKEDLY INCREASED.
ORALLY ADMIN BERBERINE SULFATE SHOWED LOW TOXICITY DUE TO POOR ABSORPTION FROM DIGESTIVE TRACT. IP ADMIN RESULTED IN HIGH TOXICITY.
Probable Routes of Human Exposure
Chemie und Industrie
Pharmakologische Informationen
Absorption, Distribution and Excretion...MAY BE ABSORBED THROUGH THE SKIN... /BERBERINE/
Verwendung und Herstellung
UsesMEDICATION
General Manufacturing Information
/BERBERINE IS/ ALKALOID, USUALLY AS SULFATE; OBTAINED FROM RHIZOMES AND ROOTS OF HYDRASTIS CANADENSIS.
/BERBERINE/...BEHAVES AS A QUATERNARY BASE, FORMING SALTS BY REPLACEMENT OF THE OH GROUP: PERKIN, JR, J CHEM SOC 113, 503 (1918). /BERBERINE/
Anwendungen
VerwendenVarious beneficial effects on the cardiovascular system and significant anti-inflammatory activities.Berberine has been shown to lower elevated blood glucose as effectively as metformin.Berberine seems to act as an herbal antidepressant and a neuroprotect
Anbieter100 Anbieter
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖北威德利化学试剂有限公司186-02735115 18062128043 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
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