HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Isoluminol
ISOLUMINOL · IsoluMinol 4-Aminophthalhydrazid · 4-AMINOPHTHALHYDRAZIDE · 4-AMINOPHTHALOYLHYDRAZINE · 6-Aminophthalazine-1,4-diol · 4-Aminophthalic acid hydrazide · 6-Amino-2,3-dihydro-1,4-phthal- · 4-AMINOPHTHALHYDRAZIDE MONOHYDRATE
Identifikatoren & physikalische Daten
| CAS No. | 3682-14-2 |
|---|---|
| Summenformel | C8H7N3O2 |
| Durchschnittliche Molmasse | 177,16 g/mol |
| Monoisotopische Masse | 177,05382646 g/mol |
| SMILES | Nc1ccc2c(=O)[nH][nH]c(=O)c2c1 |
| InChIKey | HUDPLKWXRLNSPC-UHFFFAOYSA-N |
| PubChem CID | 95014 |
| ChEMBL | CHEMBL14882 |
| EC No. | 628-451-4 |
| DTXSID | DTXSID70958029 |
Chemische & physikalische Eigenschaften
| XLogP | -0,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 84,2 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 13 |
| Formalladung | 0 |
| Komplexität | 254 |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| Schmelzpunkt | 300 °C (lit.) |
| Dichte | 1.433±0.06 g/cm3(Predicted) |
| Lagerbedingungen | Keep in dark place,Inert atmosphere,Room temperature |
| Löslichkeit | Soluble in ammonium hydroxide, sodium carbonate or other base. |
| pKa (Säurekonstante) | 10.78±0.20(Predicted) |
| Aggregatzustand | Solid |
| Farbe | White to Off-White |
| BRN | 164804 |
| InChI | InChI=1S/C8H7N3O2/c9-4-1-2-5-6(3-4)8(13)11-10-7(5)12/h1-3H,9H2,(H,10,12)(H,11,13) |
| InChIKey | HUDPLKWXRLNSPC-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=CC(N)=C2)C(O)=NN1 |
| CAS Datenbank | 3682-14-2(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| F | 10-23 |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 29280000 |
| R-Sätze (R) | 36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Eye Irrit. 2Skin Irrit. 2STOT SE 3 |
Anwendungen & Verwendung
Verwenden
4-Aminophthalhydrazide has been used in:chemiluminescence-based reactive oxygen species (ROS) assay in bone marrow (BM) neutrophils post-Yersinia pseudotuberculosis infectionneutrophil ROS assays post-K. pneumonia exposure neutrophil ROS assays in response to formylated-methionine-leucine-proline