4-Azoniaoctamethylendiammoniumtrichlorid
SPERMIDINE 3HCL · SPERMIDINE HCl · SPERMIDINE HYDROCHLORIDE · N-(3-AMINOPROPYL)-1,4-DIAMINO-BUTANE TRIHYDROCHLORIDE · Spermidie 3HCL · SPD·3HCl · SperMidine tri · SPERMIDINE 3HC
Identifikatoren & physikalische Daten
| CAS No. | 334-50-9 |
|---|---|
| Summenformel | C7H22Cl3N3 |
| Durchschnittliche Molmasse | 254,6 g/mol |
| Monoisotopische Masse | 253,087931 g/mol |
| SMILES | Cl.Cl.Cl.NCCCCNCCCN |
| InChIKey | LCNBIHVSOPXFMR-UHFFFAOYSA-N |
| PubChem CID | 9539 |
| ChEMBL | CHEMBL1256356 |
| ChEBI | CHEBI:233088 |
| EC No. | 206-379-0 |
| DTXSID | DTXSID0059825 |
| Lokaler Name | 4-Azoniaoctamethylendiammoniumtrichlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 64,1 |
|---|---|
| H-Brücken-Donoren | 6 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 13 |
| Formalladung | 0 |
| Komplexität | 56,8 |
| Stoffklassen | Other Uses -> Biochemical Research |
| Physical Description | Solid[Merck Index] White hygroscopic powder[Sigma-Aldrich MSDS] |
| Schmelzpunkt | 257-259 °C(lit.) |
| Lagerbedingungen | room temp |
| Löslichkeit | H2O: 1 M at 20 °C, clear, colorlessSoluble in water (100 mg/ml), and ethanol. |
| Aggregatzustand | Crystalline Powder |
| Farbe | White |
| pH | 3.0-6.0 (25℃, 1M in H2O) |
| Biologische Quelle | microbialsynthetic |
| BRN | 3552356 |
| Kosmetik-Inhaltsstoffe Funktionen | HAIR CONDITIONING |
| InChI | InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H23*1H |
| InChIKey | LCNBIHVSOPXFMR-UHFFFAOYSA-N |
| SMILES | C(CCCN)NCCCN.Cl.Cl.Cl |
| CAS Datenbank | 334-50-9(CAS DataBase Reference) |
| EPA chemische Informationen | 1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride (334-50-9) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 48 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | 1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| Gefahrenübersicht | Causes convulsions in acute intraperitoneal studies of rats and mice[RTECS] A skin and strong eye irritant[Sigma-Aldrich MSDS] |
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| F | 3-10 |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29212900 |
| RTECS-Nr. | EJ7023000 |
| R-Sätze (R) | 36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Eye Irrit. 2Skin Irrit. 2 |
Anwendungen & Verwendung
Beschreibung
Spermidine trihydrochloride is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins. Additionally, spermidine stimulates T4 polynucleotide kinase activity. It is involved in growth, development, and the stress response in plants.
Verwenden
Spermidine Trihydrochloride is a NOS1 inhibitor and NMDA and T4 activator. Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. It was in a structural and functional study of polyamines, where potassium and sodium ions were found to promote different effects when binding with polyamines. Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements.