HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N1-(2-Aminophenyl)-N7-phenylheptanediamide
NKL 22 · HDACi-4b · MDK-4154 · NKL22, >98% · NKL 22, >98% · HDACi-4b (NKL22 · HDAC inhibitor IV · NKL 22, 10 mM in DMSO
Identifikatoren & physikalische Daten
| CAS No. | 537034-15-4 |
|---|---|
| Summenformel | C19H23N3O2 |
| Durchschnittliche Molmasse | 325,412 g/mol |
| Monoisotopische Masse | 325,17902698 g/mol |
| SMILES | Nc1ccccc1NC(=O)CCCCCC(=O)Nc1ccccc1 |
| InChIKey | ZAIULUYKQLVQFH-UHFFFAOYSA-N |
| PubChem CID | 9543539 |
| ChEMBL | CHEMBL277805 |
| DTXSID | DTXSID60429495 |
Chemische & physikalische Eigenschaften
| Schmelzpunkt | 159-161°C |
|---|---|
| Siedepunkt | 627.9±40.0 °C(Predicted) |
| Dichte | 1.212±0.06 g/cm3(Predicted) |
| Lagerbedingungen | -20°C Freezer |
| Löslichkeit | DMSO, Methanol |
| Aggregatzustand | Beige solid |
| pKa (Säurekonstante) | 14+-.0.70(Predicted) |
| Farbe | Off-White to Pale Beige |
| InChI | 1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24) |
| InChIKey | ZAIULUYKQLVQFH-UHFFFAOYSA-N |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | WGK 2 |
|---|---|
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Verwenden
Histone deacetylase inhibitor IV. A cell-permeable pimeloylanilide compound that acts as a FXN-(frataxin gene) specific HDAC inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedrich’s ataxia) cells due to hypoacetylation of histones H3 and H4.