Cefepime dihydrochloride monohydrate
Grundinformationen
- CAS
123171-59-5- Standard-SMILES
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(C[N+]3(C)CCCC3)CS[C@H]12)c1csc(N)n1.Cl.O.[Cl-]- InChIKey
LRAJHPGSGBRUJN-OMIVUECESA-N- Summenformel
- C19H28Cl2N6O6S2
- Durchschnittliche Molmasse
- 571,5 g/mol
- Monoisotopische Masse
- 570,0888804
Überblick
Cefepime hydrochloride is a hydrochloride that is the monohydrate of the dihydrochloride salt of cefepime. It has a role as an antibacterial drug. It is a cephalosporin, a hydrate and a hydrochloride. It contains a cefepime(1+).
Namen und Bezeichner
- Bevorzugter Name
- Cefepime dihydrochloride monohydrate
- IUPAC
- (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;chloride;hydrate;hydrochloride
- Englischer Name
- Cefepime hydrochloride
- Summenformel
- C19H28Cl2N6O6S2
- Molmasse
- 571.49
Namen und Synonyme
123171-59-5Cefepime hydrochloridecefepime dihydrochloride monohydrateCefepime HClCefepime dihydrochloride hydrateCefepime hydrochloride monohydrateCefepime In Plastic ContainerBMY-28142 2HCl.H2OCefepime (as hydrochloride)CHEBI:31368BMY-28142 DIHYDROCHLORIDE MONOHYDRATEI8X1O0607P
Weitere Namen anzeigen
Cefepime HydroclorideCefepim dihydrochlorideCefepime dihydrochloride monohydrate for system suitability CRSAxepimCepimexCEPEFIME HCLCefepime 2HClefepime hydrochloride
Cefepime Hydrochloride and DextroseNSC-760051EXBLIFEP COMPONENT CEFEPIME HYDROCHLORIDERefChem:57264CEFEPIME AND DEXTROSE IN DUPLEX CONTAINERCEFEPIME HYDROCHLORIDE IN PLASTIC CONTAINER(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetylamino)-3-(1-methylpyrrolidinium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate dihydrochloride monohydrateMaxipime
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 202 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 12
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 35
- Formalladung
- 0
- Komplexität
- 874
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 150 °C · 150°C (dec.)
- storage temp.
- 2 · Keep in dark place,Inert atmosphere,2-8°C
- Löslichkeit
- Soluble in DMSO
- Aggregatzustand
- powder
- Farbe
- white to faint yellow
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- LRAJHPGSGBRUJN-ZVMPLFRQNA-N
- SMILES
- C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)C[N+]1(CCCC1)C)(=O)O.[Cl-].Cl.O |&1:5,7,r|
- CAS Datenbank
- 123171 · 123171-59-5(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 1.5% (1 of 68) of reports.
Danger
H317 (98.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P233, P260, P261, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P354+P338, P317, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 68 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesSkin Sens. 1 (98.5%)
Toxikologische Informationen
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Cefepime hydrochloride
vLess-DILI-concern
3
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29419000
- risk_code
- 36/37/38-42/43
- hazard_code
- Xi
- safety_code
- 22-26-36/37/39
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
CEFEPIME HYDROCHLORIDE
Cephalosporins [CS]; Cephalosporin Antibacterial [EPC]
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Anwendungen
VerwendenCefepime hydrochloride monohydrate is used as a broad spectrum antibiotic targeting a wide variety of naturally antibiotic resistant Gram-positive and Gram-negative bacteria. It is resistant to hydrolysis by common plasmid and/or chromosomally-mediated β-lactamases.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Ergänzende Hinweise
DefinitionChEBI: A hydrochloride that is the monohydrate of the dihydrochloride salt of cefepime.
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